ObjectiveTo study the relationship between serum homocysteine level and primary hypertension and acute cerebral infarction patients. Methods96 acute cerebral infarction patients were selected,including 42 cases with pure cerebral infarction( cerebral infarction group) and 54 cases of primary hypertension and cerebral infarction patients( hypertension and cerebral infarction group) ;48 cases of pure primary hypertension were selected as hypertension group;40 healthy persons were selected as control group. To observe the serum Hcy level of all subjects and the cerebral infarction situation of cerebral infarction group, hypertension and cerebral infarction group. ResultsThe serum Hcy level of moderate hypertension patients was higher than mild hypertension patients (P ＜ 0.05 ), and the serum Hcy level of severe hypertension patients was higher than moderate hypertension patients( P ＜0.05). The serum Hcy level of hypertension group, cerebral infarction group, hypertension and cerebral infarction group was higher than the control group(all P ＜0.01 ),and the serum Hcy level of hypertension and cerebral infarction group was higher than hypertension group,cerebral infarction group( P ＜ 0.05). The incidence of large area infarction, recurrent infarction,multifocal infarction of hypertension and cerebral infarction group were higher than cerebral infarction group( all P ＜ 0.05). ConclusionThe increase of serum Hcy level had a certain relationship with hypertension complicated with cerebral infarction, and it was related to the severity of cerebral infarction. Conventional Hcy level detection of patients had important clinical value for prediction,treatment and prognosis of patients with primary hypertension and acute cerebral infarction.

Objective To explore the correlation between endocrine therapy adherence and illness perception (IP) in breast cancer patients. Methods From January to June 2017, a total of 100 breast cancer patients treated in Oncology Department at a Class Ⅲ Grade A hospital in Daqing City of Heilongjiang Province were selected as subjects by convenience sampling. The endocrine therapy adherence and IP of patients were investigated with the breast cancer endocrine therapy adherence questionnaire and Brief Illness Perception Questionnaire (BIPQ). Pearson correlation and multiple linear regression were used to analyze the correlation between them. Results A total of 98 valid questionnaires were collected totally. Except for entry 3, 6 and 7, the scores on entries and total score of IP of patients were positively correlated with the endocrine therapy adherence (P<0.05). Except for entry 7, score of each entry and total score all entered the regression equation of adherence. Conclusions The IP of breast cancer patients has a correlation with the endocrine therapy adherence. We should raise the level of positive IP of patients by positive direction and intervention so as to improve endocrine therapy adherence of patients.

Objective To observe the relationship between different degree of cerebral edema and multiple organ dysfunction syndrome (MODS) of exertional heat stroke (EHS) patients. Methods The patients with EHS admitted to intensive care unit (ICU) of the 159th Hospital of PLA from June 2015 to June 2017 were enrolled. The electrical impedance perturbation coefficient (EIDC) of bilateral cerebral hemispheres were monitored at 2, 24 and 72 hours after the onset of the disease by BORN-BE non-invasive dynamic cerebral edema monitor, and the patients were divided into 9+ group, 10+ group and 11+ group according to the resistance of the measured mean impedance coefficients. Fasting venous blood of the patients were acquired after 2 hours and 72 hours of the disease, the levels of serum interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), nitric oxide (NO), nitric oxide synthase (NOS), cardiac troponin I (cTnI), MB isoenzyme of creatine kinase (CK-MB), creatinine (Cr), β2-microglobulin (β2-MG), alanine aminotransferase (ALT) and aspartate transaminase (AST) were detected. The occurrence of MODS within 72 hours was recorded. Linear regression analysis of the correlation between EIDC and MODS was done. Results All 124 EHS patients were male; the age was (22.10±4.43) years. Among them, 20 in EIDC 9+ group, 61 in 10+ group, and 43 in 11+ group. There were no significant differences in the levels of IL-1β, TNF-α, NO, NOS, cTnI, CK-MB, Cr, β2-MG, ALT, AST after onset of 2 hours among different EPIC groups; all the indexes of 72 hours were significantly higher than those of 2 hours in each group; and the higher the EIDC, the more obvious increase of each index [EIDC 9+ group, 10+ group, 11+ group at 72 hours IL-1β (ng/L): 12.05±3.75, 18.49±7.94, 23.21±10.44;TNF-α (ng/L): 13.10±3.18, 18.92±7.23, 23.40±10.17; NO (μmol/L): 99.50±12.10, 111.41±17.75, 120.81±15.58;NOS (kU/L): 47.95±8.33, 56.70±12.12, 63.37±12.60; cTnI (ng/L): 92.75±20.92, 107.20±18.96, 117.30±14.53;CK-MB (U/L): 73.55±9.25, 83.23±13.19, 93.49±12.25; Cr (μmol/L): 165.30±9.41, 176.62±9.83, 180.09±10.14;β2-MG (mg/L): 16.45±2.68, 19.07±3.68, 22.05±3.93; ALT (U/L): 500.10±87.05, 563.90±91.28, 612.16±90.61, AST (U/L): 414.30±53.35, 470.51±73.83, 512.09±81.29, respectively, two-two comparison all P ＜ 0.05], the higher of the MODS incidence [40.00 % (8/20), 65.57% (40/61), 83.72% (36/43), x2= 12.199, P = 0.002]. Linear regression analysis showed that the degree of cerebral edema was positively correlated with the incidence of MODS (R2= 0.905, P = 0.002). Conclusion The higher of the EIDC, the more severe of cerebral edema, the stronger of the inflammatory reaction, and the more severe damage of heart, liver, kidney and other organs in EHS patients within 72 hours.