Objective:To explore the effects of quality-sensitive indicators in the management of disinfection supply room.Methods:The management model modified based on quality-sensitive indicators was applied in the Disinfection Supply Room of the Second Affiliated Hospital of Fujian Medical University since October 2016. The pass rate of the instrument inspection and the quality indicators of the disinfection supply room before and after modification were compared.Results:The pass rates of instrument inspection and Bowie-Dictest in the disinfection supply room after modification were better than those before modification ( P<0.01) . After modification, the qualification of the disinfection supply room in terms of instrument recovery, washing, packaging, item distribution and sterilization was better than that before modification ( P<0.05) . Conclusions:In the prevention of nosocomial infection in the disinfection supply room, the application of quality-sensitive indicators can effectively improve the qualification in instrument recovery, washing, packaging and sterilization, thus ensuring the quality of device disinfection.