Objective: To observe the effects of type 2 diabetes mellitus patients with hypertension on lipid metabolism and insulin sensitivity. Methods: A case-matched study of fasting plasma glucose (FBG), total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HIDL), low density lipoprotein cholesterol (LDL), insulin (FIN), C-peptide (FCP) and insulin sensitivity index (ISI) were detected in type 2 diabetes mellitus patients with and without hypertensiorn. Results: Twenty patients with type 2 diabetes mellitus complicated hypertension had higher TG、 FINS and FCP, lower HDL and ISI levels than 20 patients with type 2 diabetes mellitus without hypertension. Conclusion: Type 2 diabetes mellitus with hypertension had more remarkable lipid metabolic disorder and insulin resistance than type 2 diabetes mellitus without hypertension.

Amyotrophic lateral sclerosis is a progressive neurodegenerative disorder involving primarily motor neurons in the cerebral cortex,brainstem and spinal cord.The clinical diagnosis of ALS may be categorized into four levels of certainty according to clinical and electrophysiological examination,depending on the presence of upper and lower motor neuron signs together in the same topographical anatomic region in either the brainstem(bulbar cranial motor neurons),or cerival,or thoracic,or lumbosacral spinal cord(anterior horn motor neurons).Electromyography is of great importance in the diagnosis of ALS.Neruoimaging studies and clinical laboratory studies are helpful to exclude other disorders.

or =0.05 ng/ml (n=110) and cTnI-negative with serum cTnI

Purpose:To study the effect of recombinated human granulocyte colony-stimulating factor (rhG-CSF,filgrastim) on leukopenia induced by chemotherapy.Methods:Ten cases of leukopenia of grade Ⅳ induced by chemotherapy of malignant tumor were treated with rhG-CSF . When WBC2.5?109/L, rhG-CSF was stopped.Results:All patients with leukopenia of grade Ⅳ recovered to normal after treatment with rhG-CSF , the average time of usage was 6.8 days. The infection rate was 60%(6/10). Conclusions:Filgrastim is effective in the treatment of leukopenia of grade Ⅳ after chemotherapy, rhG-CSF decreases infection and facilitates chemotherapy.

Animal models using for research the cancer matestasis should be entirely similar to the clinical pathological process in patients.Currently,two kinds of animal models with genetic engineering and human tumor xenografts are available in laboratory,which provide a possible research tool to investigate the mechanism of tumor metastasis and explore the experimental treatment.In these models,the techniques including how to select the cell lines and using real-time imaging detection are very important factors.

Thyroid-associated ophthalmopathy (TAO) is an autoimmune disease,and the pathogenesis of TAO is still unclear at present,so it is difficult to take proper prevention and treatment.TAO is a polygenic disease,it is a result of both genetic and environmental factors.Now a large number of researchers showed genetic predisposition of TAO,such as associated genes about cytokine (CK),human leukocyte antigen DR gene (HLA-DR),uridine diphosphate glucose phosphate dehydrogenase gene (UGDH),parathyroid hormone-like hormone gene (PTHLH),human beta defensin-2 gene (HBD-2),cytotoxic T lymphocyte associated antigen-4 gene (CTLA4),cluster of defferentiation 86 gene (CD86) and CD103 gene,cardiac calsequestrin-2 gene (CASQ-2),Toll-like receptor-9 gene (TLR-9),peroxisome proliferation factor receptorγ activation gene (PPAR-γ2),hyaluronan synthase gene (HAS),hyaluronidase gene (HYAL),etc.This review summarizes the corresponding associations respectively based on specific genetic research,so as to have a system understanding to TAO susceptibility genes.

The paper introduces the system structure of the knowledge discovery system of digital library of medical university,including knowledge service interaction layer,knowledge discovery processing layer,data mining & transmission layer and basic data resource layer,and discusses the knowledge service mode of the digital library of medical university supported by knowledge discovery,namely,the knowledge service mode based on embedded system,document database and collaborative mode.

Objective To investigate the protective effects of Apigenin (APG) on hepatic in diabetic rats.Methods The experimental diabetes model were made by intraperitoneal injecting STZ. The rats were randomly devided into six groups: a normal control group, a diabetes model control group, APG 5, 10, 20 and 40 mg/kg treated groups, and the drug was given by intraperitoneal injection. 4 weeks later, the body weight, ratio of hepatic weight and body weight were detected; the histopathological changes of hepatic tissue were observed by HE staining; the content of ALT/AST/LDH in serum were determined; the activity of SOD/GSH-Px/CAT and the content of MDA in hepatic tissue were determined.Results Compared with the diabetes model control group, the body weight of APG(10, 20, 40) mg/kg treated groups were significantly increased (261.3 ± 15.8 g, 274.2 ± 18.4 g, 265.9 ± 19.0 gvs. 250.8 ± 21.4 g,P<0.05 orP<0.01), and the ratio of hepatic weight and body weight were significantly decreased (27.7 ± 5.69, 26.2 ± 4.91, 27.3 ± 4.58vs. 32.9 ± 5.85,P<0.05 orP<0.01); the hepatic tissue histopathological changes of APG-treated groups were significantly improved; the level of ALT in serum of APG (5, 10, 20 and 40) mg/kg treated groups were significantly decreased (1 039.3 ± 453.9 U/L, 917.6 ± 445.2 U/L, 828.4 ± 309.5 U/L, 721.7 ± 318.3 U/Lvs. 1 205.2 ± 484.1 U/L;P<0.05 orP<0.01), AST were significantly decreased (97.8 ± 23.8 U/L, 90.1 ± 19.6 U/L, 81.7 ± 15.7 U/L, 86.4 ± 19.2 U/Lvs. 105.3 ± 25.7 U/L;P<0.05,P<0.01), LDH were also significantly decreased (983.7 ± 192.6 U/L, 918.3 ± 212.9 U/L, 830.4 ± 174.2 U/L, 871.8 ± 183.1 U/Lvs. 1 102.8 ± 211.6 U/L;P<0.05 orP<0.01); the activity of SOD in hepatic tissue of APG (10, 20, 40) mg/kg treated groups were significantly increased (10.5 ± 1.9 U/mg, 11.6 ± 2.1 U/mg, 10.5 ± 2.0 U/mgvs. 9.1 ± 1.8 U/mg,P<0.05,P<0.01), GSH-Px were significantly increased (14.2 ± 2.7 U/mg, 15.3 ± 2.9 U/mg, 14.6 ± 2.6 U/mgvs. 12.9 ± 2.3 U/mg;P<0.05, P<0.01), CAT were significantly increased (3.15 ± 0.90 U/mg, 3.58 ± 0.88 U/mg, 3.31 ± 1.09 U/mgvs. 2.58 ± 0.79 U/mg,P<0.05 orP<0.01), and the content of MDA was significantly decreased (5.03 ± 1.70 nmol/mg, 4.66 ± 1.51 nmol/mg, 4.73 ± 1.65 nmol/mg vs. 5.98 ± 1.62 nmol/mg;P<0.05 orP<0.01). And the treatment effect of APG 20 mg/kg groups was the most significant.Conclusion APG had antioxidant enzyme activity, besides its reducing the damage of free radical, and protecting the hepatic tissue of diabetic rats effects.

Objective To evaluate the depressed mood status of nurses from 2009 to 2013 in China,and to provide evidence for launching psychological health education.Methods PubMed,VIP database,the CNKI database were searched to find the published literatures about the detection of depressed mood among nurses from January 2009 to December 2013.According to exclusion criteria the studies were screened,and the qualities of included studies were evaluated and Meta-analysis software was used for Meta-analysis.Results Totally 633 literatures were included.After screening a total of 583 literatures were excluded,after further study on the full text of literature,eventually 30 literatures were included,a total of 12 626 people,6 946 cases were detected with depressed mood.The Meta-analysis results showed that the total depressed mood detection rate was 42.5％.There was no significant difference among genders,working years,and educational background; but ages may play a role in occurrence of depression.Conclusions Depressed mood of Chinese nurses was significantly higher than the general population,and older nurses were suffered from more serious depression.