Objective To systematically review the existing evidence about the effect of medial and lateral (crossed) entry pins versus only lateral entry pin fixation on the supracondylar fractures of the humerus in children.Methods Eligible studies were identified in Cochrane library,the Cochrane Bone,Joint and Muscle Trauma Group (till March 2011 ),Medline (from 1966 to March 2011 ),EMbase (from 1966 to 2011 ),CBM (from January 1979 to March 2011 ),PubMed,Wanfang Data (from 2000 to March 2011 ) and CNKI and the references of the included studies and several Chinese orthopedic journals were manually searched.Then,the randomized controlled trials (RCTs) and quasi-randomized controlled trials (CCTs) about two entries (crossed and only lateral pinning) for supracondylar fractures of humerus in children were collected.After evaluation of methodology with the enrolled studies,available data was extracted and systematic review was conducted via the method recommended by the Cochrane Collaboration.Results In total,five RCTs involving 311 patients were involved.Compared with the preoperative data,the meta-analysis results showed no significant difference in reduction stability in terms of change in Baumann angle and Carrying angle between the two groups.For the postoperative function outcome including complete reduction,Flynn grade and full return to function,no significant difference was found between the two groups.For the postoperative complications,there was no difference in the infection of pin tract,though lateral entry resulted in a significant lower incidence of the iatrogenic nerve injury compared with the medial and lateral entry.Conclusions With the Kirschner wire fixation for supracondylar fractures of humerus in children,current existing evidences indicate that the lateral entry of pinning has similar results in reduction stability,function outcome and incidence of pin tract infection compared with medial and lateral entry.Nevertheless,lateral entry,as a safe pinning technique,may effectively decrease the risk of iatrogenic nerve injury

OBJECTIVETo observe the effect of β₃adrenoceptors (β₃-AR) activation on rat thoracic aorta smooth muscle contractility and the possible related mechanism.

METHODSThe endothelium removed thoracic aorta was pre-contracted with 30 mmol/L KCl physiological saline solution (PSS). Then the tension of the thoracic aorta was recorded in presence of BRL37344 (BRL) to determine the action of β₃-AR. The tension of the thoracic aorta was also recorded in the presence of Propranolol (PRA), SR59230A (SR), L-NNA, H-89 and Iberiotoxin (IBTX) respectively to reveal the underling mechanism of β₃-AR activation on rat vascular smooth muscle. Immunohistochemistry was adopted to confirm the existence and the distribution of β₃-AR in rat thoracic aorta.

RESULTSThe results showed that: (1) The thoracic aorta was relaxed by β₃-AR activation, with a relaxation percentage of (10.59 ± 0.79). (2) β₃-AR was expressed in both endothelial and smooth muscle layer in thoracic aorta sections of rats. (3) PRA did not block the effect of BRL on the thoracic aorta. The relaxation actions of BRL could be antagonized by pre-incubating the thoracic aorta with SR. (4) L-NNA (a NOS inhibitor) and H-89 (a PKA inhibitor) reversed the relaxation effect of BRL on vascular smooth muscle. (5) The effect of BRL was decreased after application of Ibriotoxin (IBTX), a large conductance calcium dependent potassium channel blocker.

CONCLUSIONThe results confirmed that activation of β₃-AR led to relaxation of thoracic aorta smooth muscle. The relaxation action of β₃-AR on smooth muscle of rat thoracic aorta was related to activation of NOS and PKA signaling pathway. Large conductance Ca²⁺-K⁺ channels were involved in the relaxation action of β₃-AR activation on rat thoracic aorta smooth muscle.

Animals ; Aorta, Thoracic ; physiology ; In Vitro Techniques ; Isoquinolines ; Large-Conductance Calcium-Activated Potassium Channels ; physiology ; Muscle Contraction ; Muscle Relaxation ; Muscle, Smooth, Vascular ; physiology ; Nitroarginine ; Peptides ; Propanolamines ; Propranolol ; Rats ; Receptors, Adrenergic, beta-3 ; physiology ; Signal Transduction ; Sulfonamides

Objective To determine the therapeutic effect of recombined rat insulin-like growth factory 1 gene and transforming growth factor beta-1(TGF-?_1)gene on anterior cruciate ligament transection(ACLT)- induced osteoarthritis-like changes in NZW rabbit knee joints.Methods Eighteen NZW rabbits were divided into 3 groups randomly after osteoanhritis was established by ACLT and another six rabbits were used as normal control group(group 1).Chondrocytes which had been transfected with IGF-1 gene,co-transfected with TGF-?_1 and IGF-1 gene(group 3,4)were injected into the rabbits knee joints.Experimental control group(group 2)only had ACLT bul was not transfected.After 4,8 weeks,rabbits were sacrificed and their joints were evaluated by morphological grades,histological examination,in situ hybridization examination,immunohistochemistry exami- nation,and transmission electron microscopy examination(TEM).Results The morphological grades showed that the normal control group had a very significant difference with the experimental control group(P

Objective:To conduct a systematic review and Meta-analysis of the efficacy and safety of Apatinib and tegafur in colonic cancer.Methods:With "Apatinib" "Tegafur" "Colonic cancer" as keywords, PubMed, Embase, Web of Science, Cochrane Library, WanFang Data, VIP, CNKI and CBM were searched from inception to December 2020 to collect randomized controlled trail about treatment for colonic cancer with Apatinib and Tegafur. Evaluated the portion remission and stable duration and progression-free survival. Meta-analysis was performed by using RevMan 5.3 software.Results:Meta-analysis showed that in colonic cancer patients, the portion remission and stable duration, tumor progression of Apatinib were not inferior to those of Tegafur ( RR=1.10, 95% CI: 0.71-1.71, P=0.640; RR=0.51, 95% CI: 0.28-1.32, P=0.205). But for progression-free survival, Apatinib was superior to Tegafur in overall patients( SMD=0.90, 95% CI: 0.42-1.37, P<0.000 1). Conclusion:In the treatment of colon cancer, compared with Tegafur, Apatinib can effectively improve the progression-free survival and has better overall survival.

OBJECTIVETo evaluate the significance of method of "tonifying the lung to check the liver" for treatment of chronic cholecystitis.

METHODSForty cases were randomly divided into a treatment group and a control group. The treatment group were treated with acupuncture and moxibustion by the method of "tonifying the lung to check the liver", and the control group with routine moxibustion.

RESULTSAfter treatment of one day, pain improved significantly in the two groups (P < 0.001), with no significant difference between the two groups; and 15 days after treatment, the treatment group was superior to the control group in the improvement of pain.

CONCLUSIONTCM syndrome differentiation has an important significance in clinical acupuncture and moxibustion, and the therapeutic principle "tonifying the lung to check the liver" in classical TCM theories is of scientific basis.

Acupuncture Therapy ; Cholecystitis ; Humans ; Liver ; Lung ; Moxibustion

Objective To evaluate effects of dietary intervention on self-efficacy and metabolic control of patient with type 2 diabetes. Methods A self-control designed research was conducted to 70 patients with type 2 diabetes at clinic receiving diet intervention. Before intervention and 1 month after, body mass index,waist, total cholesterol, high density lipoproteins, low density lipoproteins and uric acid were tested to evaluate the metabolic control. After 3 month, HbA1c was monitored to evaluate glycemic control. Meanwhile,before intervention and 1,3 month after, self-efficacy was investigated. Results One month later, body mass index, waist, blood lipid were lower than before, HbA1c was reduced 0.78%, the total score of self-efficacy and the dimension of nutrition, monitoring and medical were improved. Conclusions The dietary intervention was beneficial for improving metobolic control and self-efficacy of patients.

Objective To explore nursing logo applying in urology safety management,and ensure clinical medical nursing and patients' safety,secure the safety of nursing work orderly.Methods 120 patients hospitalized in July,2010 were tandomly divided into experimental and control group with 60 cases in each group.Both groups accept general behavior instruction with experimental group applying nursing logo in addition.Patients were surveyed about the satisfaction of nursing logo and nursing safety measures at discharge respectively.Results The satisfaction rate were 96.7％ and 58.4％ in experimental and control group respectively,the difference was statistically significant( x2 =20.15,P ＜0.01 ).Conclusions Nursing logo can effectively prevent the occurrence of recessive unsafe factors,can improve patients' satisfaction and security.

Objective To discuss the methods and effect of structuring standardized management model and to search the strict quality control method of first class nursing quality in order to provide reference bases for improving the quality of nursing and ensuring nursing security.Methods We formatted a first class nursing control group and formulated standardized quality control methods.Then a reasonable supervisory mechanism was established and we used the hierarchical management mode to inspect the nursing quality per week and per month.In the end,through summary feedback and tracking ways,the quality of nursing was well controlled.Results By comparison,there were significant differences between first class nursing quality and third class nursing quality,nurses defect under standardized management mode improved to 59.60％,and it was significantly different compared to the result in 2009 ( 33.65％ ) ( x2 =5.35,P ＜ 0.05 ).The punishment rate decreased to 0.55％,it was obviously lower than the results surveyed in 2009 ( 11.22％ ) ( x2 =53.49,P ＜0.05).Conclusions First class nursing standardized quality control methods is a seamless management that can help to continuously improve the quality of nursing and ensure the nursing safety.

OBJECTIVETo observe the therapeutic effect of intradermal needle therapy combined with Tuina on lumbar disc herniation.

METHODSOne hundred and fifty patients of lumbar disc herniation were treated with intradermal needle combined with Tuina. Trundle, rub the lumbar region for relaxing the lumbar muscles; pull and extend the lumbar region with traction and vibration, and pull the loin afterward and obliquely pull the loin, followed by compulsory straight-leg raising test, stretching sciatic nerve and hamstring muscle. Finally, rubbing method was used for relaxing the muscles of the lumbar and back regions. After Tuina therapy, intradermal needle embedding at local Ashi points, and Shenshu (BL 23), Yaoyangguan (GV 3), Zhibian (BL 54), Fengshi (GB 31), Yanglingquan (GB 34). The treatment was given once other day, 5 times constituting one course. After 2 courses therapeutic effects were assessed.

RESULTSOne hundred and two cases were cured, 22 cases were markedly effective, 18 cases improved and 8 cases were ineffective, with a total effective rate of 94.7%. The symptom cumulative scores before and after treatment were (31.73 +/- 2.67) and (9.16 +/- 1.20), respectively, significantly decreasing (P<0.01).

CONCLUSIONIntradermal needle combined with Tuina has a better clinical therapeutic effect on lumbar disc herniation.

Acupuncture Points ; Acupuncture Therapy ; Adult ; Combined Modality Therapy ; Female ; Humans ; Intervertebral Disc Displacement ; therapy ; Male ; Middle Aged ; Musculoskeletal Manipulations ; Needles ; Treatment Outcome

The interspecific association of companion species in Artemisia annua community in 48 region of southwest China was analyzed by variance analysis, chi2-test and association indices. The total related variance ratio among species in A. annua community was 2.05. Among 45 species pairs of 10 main species in the community, only 4 pairs showed significant negative correlations. Chi2 test, PC, OI, DI and AC values indicated pairs 1-8 (A. annua- A. lactiflora), 1-9 (A. annua- Setaria viridis) and 1-10 (A. annua- Bidens pilosa) showed a high correlations, and common utilization to non-restrictive resources. The results indicated that there was a significant positive correlation among species,and the community was at a stable stage, showed strong ability to human interference.
Analysis of Variance ; Artemisia annua ; China ; Conservation of Natural Resources ; Drugs, Chinese Herbal ; Symbiosis