Intracranial aneurysm often result from congenital defects of regional cerebral artery wall and increased endovascular pressure.Its occurrence and development are associated with several risk factors including genetics,smoking,hypertension,cerebral atherosclerosis and vasculitis.With the application of gene chip technology for the past few years,the research of pathogenic genes associated with intracranial aneurysms was further deepened,and some susceptibility genes closely associated with the occurrence of intracranial aneurysms have been found,and this suggests that intracranial aneurysm may be a polygenic disease caused by the combined action of multiple genes.

Objective In order to provide evidence for researches related to evaluating the
humanistic caring ability of head-nurses, we developed the questionnaire and launched reliability and validity test for it. Methods Through analyzing in documents, theories and scales, launching a 2-round experts consultation for 19 experts, the questionnaire consists of 3 first-class indicators, 8 second-class indicators and 36 third-class indicators. A total of 217 nurses, from third-grade class-A hospital who had a more than 5-year clinical experience, were selected by convenient sampling. Finally, the reliability and validity of the questionnaire had been summarized. Results The Cronbach α was 0.937 for the total questionnaire and 0.743-0.898 for each sub-scales. The split half reliability coefficient for the total questionnaire was 0.801 and 0.748-8.872 for each sub-scales. Test result of questionnaire content validity demonstrate the CVI was 0.91 for the total factors and 0.83-1.00 for each factor.Through exploratory factor analysis, 8 common factors were abstracted and cumulative variance contribution rate was 65.852%. Conclusions The questionnaire, developed for evaluating the humanistic caring ability of head-nurses, shows acceptable reliability and validity, and it′s worth to be popularizing and using in future.

Objective The influencing parameters of solid and fluid computing fields for the scaffolds models with regular square holes were discussed by nonlinear fluid-solid-coupling approaches.The numerical computational resuits of which the models were regarded as both rigid body and non-linear elasticity were compared as well.Method One direct fluid-solid-coupling approach and two indirect fluid-solid-coupling approaches were adopted,and the calculating reliability of three kinds of fluid-solid coupling methods was verified.Rasults The solid-fluidcoupling computational results are obtained in light of 12 kinds of scaffolds models which are constructed by 3 groups of square side length(50,100 and 150 μm)and 4 groups of porosity(61%,65%,77%and 84%).The field parameters of those solid models including stress,strain and displacement and those fluid models including static pressure,velocity,wall shear stress and strain rate are achieved and compared.Conclusion There appear some difference between the results of porous scaffold models as a rigid body and as non-linear elasticity.The different porosity with the same pore radius or the different pore radius with the same porosity would affect the field parameters of solid models and fluid models in varying degrees.

Objective To investigate the differences of the characteristic and syndrome of patients with alcoholic cirrhosis(AC) and viral cirrhosis(VC).Methods Seventy patients with AC and 300 patients with VC in the Binzhou People's Hospital were selected as our subjects.The information including gender,age,disease history,chnical syndrome were collected.Meanwhile,the levels of Aspartate aminotransferase/alanine aminotransferase (AST/ALT),γ-glutamyl transferase (γ-GT),alkaline phosphatase (ALP) and total bilirubin (TBil) in serum were measured.Results The proportion of males in the AC group was 91.43％ (64/70),significantly higher than that of VC group(64％ (192/300),x2 =15.76,P =0.003)).The age,disease periods in AC group were (50.13 ± 12.35) years old and (2.09 ± 0.67) years,lower than the VC group ((58.66 ± 7.45) yearsold,t =3.97,P =0.042 ; (4.56 ± 1.14) years,t =5.22,P =0.034).There was no significant difference regarding of liver function index (P ＞ 0.05).The rate of nasal carp (18.57％),gum bleeding (27.14％),liver palms(64.29％),spider(45.71％) in the AC group were significantly higher than the VC group (6.33％,15.00％,47.00％,29.67％ respectively,P =0.017,0.036,0.025,0.016 respectively).The ratio of splenomegaly and esophageal varices were (81.43％) and (65.71％) in AC group,significantly lower than VC group (90.33％,86.00％ respectively,P =0.037,0.011 respectively).The cirrhosis laboratory parameters results showed AST/ALT ratio (1.97 ± 0.45),gamma-GT ((152.33 ± 23.41) U/L),ALP indicators ((232.46 ±35.16) U/L in AC group patients,which were significantly higher in the VC group(1.00± 0.22,(45.89 ± 11.23) U/L and (102.23 ± 21.78) U/L,P =0.035,0.011,0.007 respectively).Conclusion There are difference in term of characteristic,manifestations and the testing laboratory indicators between alcoholic cirrhosis and viral cirrhosis.

Objective To observe the electrocardiogram (ECG) of urban residents in non-endemic areas of Keshan disease in Ji'nan City,Shandong Province,and to provide scientific basis for health evaluation and prevention and control of Keshan disease.Methods From July 2014 to June 2015,ECGs of residents undertaken healthy examination in Shandong Ciming Physical Examination Center were collected,retrospective analysis was used to analyze residents' heart health.Statistical analysis was conducted according to sex and age groups,and the diagnosis of ECG was based on Concise Pediatric Electrocardiogram and Clinical Electrocardiography.Results Totally 31 753 ECGs were recorded,including 18 664 males accounting for 58.8％ and 13 089 females accounting for 41.2％,who were aged 6-78 years old,including 304 people 6-20 years old,18 861 people 21-40 years old,10 451 people 41-60 years old,and 2 137 people 61-78 years old.Totally 27 699 normal ECG (87.2％) and 4 054 abnormal ECG (12.8％) were detected,there were 2 212 males and 1 842 females in the abnormal ECG,the detection rates were 11.9％ (2 212/18 664) and 14.1％ (1 842/13 089) for males and females,respectively.The detection rate of female was significantly higher than that of male (x2 =34.082,P ＜ 0.01).The detection rate of ST-T change in abnormal ECG was the highest,which was 316.5/10 000 (1 005/31 753),men and women were 273.3/10 000 (510/18 664) and 378.2/10 000 (495/13 089),respectively.The detection rate of arrhythmia was 4.8％ (1 523/31 753),including 1 023 males and 500 females,and their detection rate of arrhythmia was 548.1/10 000 (1 023/18 664) and 382.0/10 000 (500/13 089),respectively.In arrhythmia,degree Ⅰ atrioventricular block (155.3/10 000,493/31 753),complete rightbundle branch block (81.6/10 000,259/31 753),ventricular premature beats (79.0/10 000,251/31 753),and atrial premature beats (48.2/10 000,153/31 753) had higher detection rates.Conclusion The detection rate of women of urban residents in Ji'nan is higher than that of men,the most common abnormal ECG is ST-T change,and the detection rate of arrhythmia is low.

Antiphospholipid syndrome(APS) is a autoimmune system disorder caused by thrombosis and is usually accompanied with persistent positive. Antiphospholipid antibodies profiles(aPLs) is the key to diagnosing APS. The most frequently detectable aPLs in current clinical applications are anticardiolipin antibodies (aCL), anti-β2 glycoprotein Ⅰantibodies (anti-β2 GPI), and lupus anticoagulant (LA).However, it is found that the current laboratory diagnostic standard for APS based on these three aPL have many defects. The standard can′t meet the clinical needs. In this article, the research and development of antiphospholipid antibody in recent years are summarized, and the clinical value of non-classified standard antibodies such as IgA antibody isotype and anti-domain 1 β2-glycoprotein I antibody are reviewed.

Objectives To develop a measurement for obesity assessment which could be used as a simple tool of risk screening. Methods The data of National Nutrition and Health Survey ( 2002 ) were used to analyze the relationship between body mass index ( BMI ), waist circumference (WC) and chronic diseases, based on which chronic disease index ( CRI ) was established. Receiver operating characteristic curve (ROC) was used to determine the cut-off of CRI and to compare the predictive effectiveness of CRI,BMI and WC on chronic diseases. The kappa test was chosen to estimate the consistency of different cut-off of CRI with BMI and WC. The odds ratios of chronic diseases in different cut-offs of CRI were calculated by multiple Logistic regression analysis. Results CRI was calculated as CRI = BMI + 3.5 WC. In ROC curve,the cut-off of CRI was 300. The predictive effectiveness of CRI was higher than that of BMI and WC. CRI at 300 showed the best consistency with 24 kg/m2 BMI and 85 cm WC (P <0. 05 ). In comparison with CRI <300,the risk of chronic diseases was significantly increased with an increase of 20 U CRI. Conclusion CRI shows good predietive effectiveness and could be used to identify those with higher risk of chronic diseases.

Objective To evaluate the clinical value of computer-aided detection (CAD) system in the diagnosis of breast cancer on mammograms. Methods The mammograms of 136 pathology-proved breast cancer cases were analyzed by CAD system. The results of CAD were compared with that made by radiologists. Results The sensitivity, specificity, and accuracy of CAD system to microcalcification lesions were 93.2% (41/44), 22.8%(21/92), and 45.6%(62/136), respectively. The sensitivity, specificity, and accuracy of CAD system to mass lesions were 82.9%(107/129), 71.4%(5/7), and 82.4%(112/136), respectively. There was middle level agreement between the detection of CAD system and that of the radiologists (Kappa_(mass)=0.424, P_(mass)=0.000; Kappa_(cal)=0.365, P_(cal)=0.013). Conclusion CAD system has the characteristics of high sensitivity and low specificity. It could be the aid of radiologists in breast cancer detection on mammograms.

Objective To evaluate medical students′ achievements of studying through the practical base website for humanistic quality education. Methods Totally 61 students from school of nursing and 135 students from the first clinical medical college of Southern Medical University in Guangzhou were organized as volunteers. They were divided into the intervention group and the control group (98 people per group) in completely random method by the Random Number Generators of SPSS 20.0. With a two-month experiment, the humanistic knowledge scores and humanistic caring ability scores of these two groups were investigated by the Humanistic Knowledge Test Paper and the Caring Ability Inventory. And the learning effects of the website by the intervention group was evaluated with the self-designed questionnaire. Results There was no significant difference (P>0.05) between students in the intervention group and the control group when it came to general information. Before the experiment, the score of humanistic knowledge test paper, the total score of caring ability inventory, the score in the dimension of cognition, patience, and courage of the intervention group were 6.29 ± 0.58, 172.40 ± 10.00, 58.98 ± 4.22, 51.56 ± 5.22, 61.86 ± 6.40, the scores of the control group were 6.36 ± 0.63, 172.65 ± 13.49, 59.31 ± 4.05, 50.83 ± 6.56, 62.52 ± 7.28, there were no significant differences between the two groups (all P>0.05). After the experiment, the score of humanistic knowledge test paper, the total score of caring ability inventory, the score in the dimension of cognition and courage of the intervention group were 7.82± 0.62, 182.34 ± 12.78, 65.04 ± 9.12, 65.17 ± 6.58, the scores of the control group were 6.37 ± 0.60, 170.73 ± 8.92, 58.29±5.61, 62.36±6.90, there were significant differences between the two groups (t=2.92-16.67, all P<0.01). The scores in the dimension of patience of the intervention group and the control group were 52.12±3.60 and 51.02±4.34, and there was no significant difference (t=1.94,P>0.05). As shown by the evaluation made by students in the intervention group about the learning effect of the website, the average score was the highest in the field of skills (3.95 ± 0.58), followed by the cognitive field (3.92 ± 0.46) and emotional field (3.75 ± 0.66). Most of the respondents believed that web-based learning could deepen students′ understanding of humanistic quality education (4.13 ± 0.57), independent web-based learning could strengthen the application of online resources (4.06±0.59) and students could master communicative skills required in different situations through web-based learning (4.05 ± 0.58). Conclusions Students are satisfied with the practical base website for humanistic quality education, the website has rich learning contents and can improve students′ interests and motivation. Through web-based learning, humanistic knowledge and humanistic caring ability of students can be improved to some extent. But the website is still in development, it needs an evaluation indicators system in order to do further research for all application effects of the website.

Objective To prepare the curcumin self-microemulsion, observe the morphology and size diameter distribution of the microemulsion, and compare the absorption kinetics of curcumin microemulsion and micelle. To investigate the best absorption segment of curcumin microemulsion in intestnum tenue and the absorption of curcumin self-microemulsion in mouse gastrointestinal tract. MethodsThe intestine in rats was cannulated in situ recirculation. The absorption of curcumin microemulsion was calculated by its decrement in intestnum tenue.The inabsorbable curcumin in all content together with feces in mouse gastrointestinal tract was obtained and used to calculate the absorption rate of curcumin. ResultsThe curcumin microemulsion presented as small spherical drops or something similar under transmission electron microscope (TEM) with the average diameter of about 21.6 nm. The absorption constants of curcumin microemulsion and micelle was 0.042 5 and 0.019 5 /h , the main segments of curcumin microemulsion absorption were intestinum duodenum and intestinum jejunum. The absorption rate of curcumin self-microemulsion was 2.5 times as much as curcumin. ConclusionThe curcumin self-microemulsion could improve the absorption of curcumin in vivo in animal evidently.