Objective:To pediatric patients with scalp venous indwelling needle infusion therapy, and special care for children, and analyze its clinical effect. Methods:from 2011 February to 2012 August in our hospital outpatient department of pediatrics infusion in 180 cases, All the children were using scalp venous indwelling needle infusion therapy, and special care for children, and observe its clinical index. Results:after the treatment, the disposable puncture success rate was 93.3%, the blood pollution rate is 5.6%, the injection time (P<0.01) and before use, contrast, statistically significant differences. Conclusion:infusion of pediatric patients with scalp superficial vein indwelling, in clinical application is safe and reliable, convenient and feasible, but also can reduce the pain of patients, reduce the workload of nursing staff, is worthy of clinical use.

Objective To investigate the condition of self-management of patient controlled analgesia pump in patients in the ICU.Methods 82 patients in ICU were selected in July 2014 and were randomly divided into the observation group and the control group with 41 cases in each.In the observation group,the PCAP was fixed on the bedrails of patients' bed and controlled by themselves to acquire satisfactory analgesia effect.In the control group,the PCAP was operated by the nurses.Pains scores was compared between the two groups.Results The different position of PCAP showed the different scores of pain in the patients.The pain scores in the observation group (2.93±1.47) was significantly lower than that in the control group (3.76±1.36),P＜0.05.Conclusions Proper position of PCAP and controlled by patients can effectively reduce postoperative pain of patients in the ICU,and then reduce their suffering and improve their comfort.

High-intensity focused ultrasound (HIFU) is a newly-developed noninvasive technique recently. Being a safe, non-radioactive and reproducible therapy, high-intensity focused ultrasound has been extensively used in the clinical treatment for a variety of solid tumors such as uterine adenomyosis. This paper aims to make a comprehensive review about this technique, focusing on the mechanism, clinical indications and contraindications, safety, efficacy and the complications of HIFU for the treatment of uterine adenomyosis.

Problem-based learning(PBL) teaching mode was applied in Urology practice of the medical students.The externs were organized to analyze and discuss a real case,having grasped enough knowledge of relative diseases,and to provide their advice about the diagnosis and treatment,changing question mark into a full stop.And then their conclusions were verified by post-operational follow-up.PBL teaching mode can increase the students'study motivations and interests and the ability to resolve practical problems,master medical knowledge,train their clinical thinking and enhance the quality of teaching and thus it is an effective teaching mode.

Objective:To observe therapeutic effect and influence of rosuvastatin on levels of interleukin (IL)-35 and nu- clear factor-κB (NF-κB)in patients with coronary heart disease (CHD).Methods:A total of 85 CHD patients were randomly divided into rosuvastatin group (n=43,received rosuvastatin calcium therapy based on routine treatment)and atorvastatin group (n=42,received atorvastatin calcium therapy based on routine treatment),both groups were treated for eight weeks all.Cardiac index (CI),cardiac output (CO),left ventricular ejection fraction (LVEF),left ventricular end-diastolic dimension (LVEDd),serum levels of IL-35 and NF-κB,and total effective rate were measured and compared be- tween two groups before and after treatment.Results:Compared with before treatment,there were significant rise in CI, CO,LVEF and IL-35 level,and significant reductions in LVEDd and NF-κB level in both groups after treatment (P<0.05 or<0.01).Compared with atorvastatin group after treatment,there were significant rise in CI [(3.54±0.72)L· min-1 ·m-2 vs.(3.88±0.83)L·min-1 ·m-2 ],CO [(3.78±0.89)L/min vs.(4.94±0.96)L/min],LVEF [(56.20 ±9.71)% vs.(63.48±14.15)%]and serum IL-35 level [(96.26±24.33)pg/ml vs.(106.92±27.26)pg/ml],and sig- nificant reductions in LVEDd [(4.71±0.89)cm vs.(4.36±0.75)cm]and NF-κB level [(21.51±5.01)ng/ml vs. (18.32± 5.17)ng/ml]in rosuvastatin group,P<0.05 all.Total effective rate of rosuvastatin group (95.35% vs. 76.19%)was significantly higher than that of atorvastatin group,P<0.05. Conclusion:Rosuvastatin possesses more sig- nificant therapeutic effect than that of atorvastatin on coronary heart disease,and its heart protection effect besides lipid lowering may be related to regulating levels of interleukin-35 and nuclear factor-κB.

Objective To detect the expression of T helper cells 9 (Th9) in the peripheral blood and the level of interleukin (IL)-9 in the plasma of rheumatoid arthritis (RA) patients,and to analyze the relationship between Th9 and clinical characteristics,and their possible role in the immunological pathogenesis of RA were explored.Methods Thirty-six patients with RA and 22 healthy controls were included.RA patients were divided into high disease activity group (n=22) and moderate disease activity group (n=14).Th9 cells were obtained from RA patients and healthy controls and detected by flow cytometery.The levels of IL-9 in RA patients and healthy controls were detected by ELISA tests.T-test and Spearman's correlation were used for statistical analysis.Results The expression of Th9 and the level of IL-9 of RA patients [(0.99±0.50)％,( 1.06±0.42 ) pg/ml,respectively] were significantly higher than normal controls[ (0.21±0.08)％,(0.69±0.13)pg/ml,respectively,all P＜0.01 ].Meanwhile,the expression of Th9 and the level of IL-9 in high disease activity group [ ( 1.18±0.52 )％,( 1.37±0.47 ) pg/ml ] were higher than those of the moderate disease activity group [ (0.69±0.25)％,(0.94±0.30) pg/ml ].There were positive correlations between Th9 and disease activity score(DAS) 28,erythrocyte sedimentation rate (ESR),C-reactive protein (CRP),the number of tender joints,the number of swollen joints and rheumatoid factor (RF),the level of IL-9 respectively.There were positive correlations between IL-9 and DAS28,ESR,the number of tender joints,and the number of swollen joints.Conclusion High expression of Th9 and level of IL-9 maybe involved in the pat-hogenesis of RA,and is associated with disease activity.These results indicate that the abnormality of Th9 may play an important role in the pathogenesis of RA.

Objective To investgate the expression of Tfh and Th9 in the peripheral blood of rheumatoid arthritis ( RA),and to analyze the relationship between those cells and disease activity,organs of involvement,ect.,and to underly the possible immunological mechananism of RA.Methods Peripheral blood Tfh cells and Th9 cells,define as the CD4+ CXCR5 + ICOS+ and CD3 + CD8+ IL-9+ population,were examined by flow cytometry in 36 patients with RA and 22 case of age-and gender-matched health controls.According to 28-joint Disease Activity Score (DAS28),patients were divied into two groups:high disease activity(n=22),moderate disease activity(n=14).And then to analyzed the correlation among the Tfh,Th9 and clinical data of RA,such as ESR,CRP,RF,the number of tender joints,the number of swollen joints and bone destruction,etc..While to analyzed the correlation between Th9 and Tfh.Results The expression of Tfh (Z=-6.082,P=0.000) and Th9 (0.989±0.498 vs 0.213±0.084,t=13.063,P =0.000 )in PBMCs of RA was significantly higher than normal controls.Meanwhile,the expression of Tfh ( 3.880 ±1.255 vs 2.678±1.022,t=2.990,P=0.005 ) and Th9( 1.181 ±0.523 vs 0.686±0.254,t =4.043,P=0.000) in high activity of group were higher than those moderate.The percentage of Tfh and Th9 in the two groups were all signifieantly higher than controls(P＜0.01 ),There was a positive correlation with Tfh and DAS28 ( r =0.571,P=0.000),ESR ( r =0.375,P =0.029),CRP( r =0.357,P =0.032 ),the number of tender joints ( r=0.598,P =0.000 ),RF ( r =0.421,P =0.023 ) and anti-CCP ( r =0.421,P =0.023 ).There were no relationship with Tfh and course,morning stiffness,the number of swollen joints,bone erosion and the abnormal of EKG.There was a positive correlation with Th9 and DAS28( r=0.461,P=0.005 ),ESR(r=0.347,P=0.042),CRP(r=0.384,P=0.210),the number of tender joints(r=0.341,P=0.042),the number of swollen joints (r =0.347,P=0.038 ) and RF( r =0.379,P =0.025 ) respectively.There were no relationship with Th9 and course,morning stiffness,CCP,the abnormal of EKG,bone erosion.There was a positive correlation with Tfh and Th9 (r=0.727,P =0.000),Conclusion The expression of Tfh and Th9 were increase significantly,which those cells were close relationship with the disease activity and some data,These results indicate that the abnormality of Tfh and Th9 may play an important role in the pathogenesis of RA.

OBJECTIVE:To upgrade the information management of the traditional Chinese medicine(TCM)pharmacy in our hospital.METHODS:The benefits and problems in implementing information management in our hospital's TCM pharmacy were discussed,and solutions for improvement were proposed.RESULT & CONCLUSION:The application of the information management system can help regulate the management of the TCM pharmacy,and establish a closer connection between traditional medicine and modern technology.

Peripheral nerve block technique is one of the basic skills necessary to residents and it is also one of the difficult points in the resident standardized training in the department of anesthesiology. In order to maximize the learning effect of the anesthesia professional residents in the case of limited number of cases, we need to constantly enrich the teaching technologies and teaching methods. Human 3D anatomy is used for theory teaching to maintain comprehension of nerve anatomy; Ultrasound-guided nerve block technique and ultrasound simulation training are used for nerve block practice to improve nerve block skills;Problem-based learning teaching method is introduced in nerve block cases to increase the residents' ability of clinical cases management.

Erythrocyte aggregation and related parameters were observed in this study.Erythrocyte aggregation index, hematocrit and fibrin fibrinogen degradation products in-creased significantly at 5 minutes after oleic acid injection. Erythrocyte electrophoretic timein native plasma delayed obviously at 5 minutes after oleic acid injection, whereas that inPBS altered very little. The concentration of plasma calcium and erythrocyte intracellularmagnesium decreased at 5 minutes, while plasma magnesium increased. The stepwise reg-ression analysis suggested that during lung injury the parameters that have greatest effect onerythrocyte aggregation were the change of hematocrit, erythrocyte intracellular magnesiumand negative charge of erythrocyte surface.