1.Progress in the Studies of Fungal Chitin Synthases
Microbiology 1992;0(02):-
Chitin is one of the most important component in fungal cell wall.Biosynthesis of chitin is a complex processes and needs several chitin synthase isoenzymes.The knowledge of structure,function and regulation of chitin synthases is mainly derived from the study of Saccharomyces cerevisiae.In contrast with the 3 chitin synthases in S.cerevisiae,7 were found in most filamentous fungi.In this review the classification and function of chitin synthases are summerized,and progress in the studies on chitin synthases of filamentous fungi which are of theoretical or medical or agricultural importance,including Aspergillus nidulans,Aspergillus fumigatus and Ustilago maydis are emphasized.Recent ad-vance of research on chitin synthase as antifungal target is also discussed.
2.CARDIOVASCULAR EFFECTS OF SOPHORAMINE
Chinese Pharmacological Bulletin 1986;0(05):-
Sophoramine ( Sa ) is an alkaloid from sophora alopecuroides. Linn., in anesthetize animals ( cat, rat and rabbit), intravenous adminstra-tion of Sa reduced rapidly and markly the arterial blood pressure. The mechanism of hypotension effect of Sa is mainly attributable to its sympathetic ganglionic blocking and direct vasodilatation. Experiment on the isolated hearts of guinea pig revealed that Sa produced negative chronotropic and positive inotropic action, and increased coronary flow simultaneously.In a study of experimental arrhythmia in animals,we observed that Sa could reduce the arrhythmia induced by aconitine in rats and decreased the incidence of ventricular fibrillation induced by chloroform in mice.
3.Progress of MRI study on amyotrophic lateral sclerosis
Chinese Journal of Practical Internal Medicine 2000;0(11):-
ALS is a progressive neurodegenerative disease affecting both lower and upper motor neurons,including the pyramidal tract.There have been no objective and effective method to evaluate the lesions of upper motor neurons.With non-invasive,sensitive and macroscopic advantages,the application of Regular MR,MRS,DWI,function MR and VBM on ALS will undoubtedly have great potentials in the diagnosis,disease monitor and therapy of ALS.
4.Endoscopic uitrasonography used in diagnosing esophageal and gastric varices
Xi-Feng MI ; Yi CUI ;
Chinese Journal of Digestive Endoscopy 2001;0(03):-
Objective To evaluate the effect of endoscopic ultrasonography(EUS)in diagnosing e- sophageal and gastric varices in portal hypertension(PHT)patients.Methods Fifty-three patients with e- sophageal and gastric varices(EV、GV)of decompensation PHT and 20 patients without PHT as control were undergone EUS and esophagogastroduodenoscopy(EGD)simultaneously.EUS detected mainly the EGV,e- sophagus and stomach collateral veins.Results EUS identified EV endoscopically in 29(54.7%)patients. EUS detected GV in 24(45.3%)patients,compared with detection in 18(34.0%)patients by esopha- gogastroduodenoscopy(EGD)(P<0.001).EUS detected PEV in 27(51%)patients.Distribution rates of PEV in F1,F2 and F3 are 0%,28.6% and 75% respectively.The comparison between groups shows sig- nificant difference(P<0.001).Splenic vein can be seen in both control and experimental groups with di- ameter 7.5?1.35mm VS 11.5?3.5mm respectively,the difference between two groups is significant(P<0.001).Proximal diameters of Azygos vein in two groups is 7.36?1.29mm VS 8.77?2.94mm respective- ly.Significant difference can be found(P<0.05).Conclusion EUS had significant value in the diagnosis of PHT with EV and GV,and especially in detecting abnormalities of extra-luminal veins.
5.Research progress of establishing cardiomyocytedisease models by human induced pluripotent stem cells
Ning CUI ; Lei LI ; Ming CUI ; Feng LAN
Basic & Clinical Medicine 2017;37(9):1331-1335
Induced pluripotent stem cell is a landmark in the stem cell study field, which has rapidly developed in the past 10 years.By obtaining induced pluripotent stem cells from somatic cell, and then differentiating into cardiomyocyte, various cardiomyocyte disease models could be established,which can be used for research of disease mechanisms, drug screening and gene therapy.This review introduces the successfully established cardiomyocyte disease models from human induced pluripotent stem cells, and points out the problems and prospects.
6.Surgical management of huge nasopharyngeal pleomorphic adenoma two cases.
Na CUI ; Li-feng AN ; Dong-dong ZHU
Chinese Journal of Otorhinolaryngology Head and Neck Surgery 2010;45(7):603-604
Adenoma, Pleomorphic
;
surgery
;
Adult
;
Female
;
Humans
;
Male
;
Middle Aged
;
Nasopharyngeal Neoplasms
;
surgery
7.Surgical management of aspergillosis limited within the vocal cord: 2 cases report.
Lin LI ; Li-feng AN ; Cui-da MENG
Chinese Journal of Otorhinolaryngology Head and Neck Surgery 2011;46(5):421-422
Adult
;
Aspergillosis
;
pathology
;
surgery
;
Female
;
Humans
;
Laryngeal Diseases
;
microbiology
;
pathology
;
surgery
;
Middle Aged
;
Vocal Cords
;
pathology
9.Perioperative changes of lymphocyte subsets and NK cells in patients with chest operation
Guangjing ZHANG ; Yushang CUI ; Feng YAN
Chinese Journal of Immunology 1986;0(04):-
Objective:To explore the perioperative dynamic changes of cellular immune function and its clinical significance in patients with chest surgery.Methods:The numbers of CD3、CD4、CD4/CD8、CD8 T lymphocyte and nature killer(NK) cells in peripheral blood were examined in 45 patients with chest surgery before operation and 1、3、5 and 7 days after operation by flow cytometry.45 patients were devided randomly into groups.The perioperative changes of T lymphocyte subsets and NK cells were compared among mediastinal disease,pulmonary operation,esophagus and gastric cardia surgery.Results:CD4/CD8 decreased 1 day after surgery and CD4 decreased at the 3rd postoperative day in patients with chest surgery.In patients with mediastinal disease,CD4/CD8 decreased 1 day after surgery and CD4 decreased at the 3rd postoperative day.In patients with pulmonary operation,CD8 decreased at the 1st day and 7th day after surgery.NK cells decreased at the 5th postoperative day CD3 increased at the 5th day after surgery.CD4/CD8 increased at the 7th day after operation.In patients with esophagus and gastric cardia surgery,CD4/CD8 decreased 1 day after operation,CD3 and CD4 increased at the 7th postoperative day.All differences are statistically significant( P
10.Analysis of endometrial carcinoma in 35 old patients
Ning HUI ; Feng XIE ; Ying CUI
Academic Journal of Second Military Medical University 2000;0(07):-
Retrospective study was carried out in 93 cases of endometrial carcinoma admitted to our hospital since Jan. 1985 to Dec. 1994. Thirty five cases were older than 60 years, and 24 cases were younger than 50 years. All of the cases had pathological diagnosis and were staged according to FIGO. When compared with the younger group, the rate of older patients with stage Ⅰa was higher (11.4% in younger and 45.4% in older, P