1.Biologic therapies in Crohn's disease.
Korean Journal of Medicine 2005;68(2):133-139
No abstract available.
Biological Therapy*
;
Crohn Disease*
2.Difficulties in diagnosis and treatment of Crohn disease.
Chinese Journal of Gastrointestinal Surgery 2013;16(4):301-303
The incidence of Crohn disease has gradually increased in recent years. The diagnosis and treatment of Crohn disease has gained more and more attention from clinicians. This article is to propose solutions to problems in the diagnosis and treatment of Crohn disease, based on evidence from clinical trials, including the diagnosis, differential diagnosis, management of steroid-refractory disease and anal fistula, and timing of surgery.
Crohn Disease
;
diagnosis
;
therapy
;
Humans
3.A case of complex Crohn's disease with severe complication.
Li TIAN ; Anliu TANG ; Fen LIU ; Qin GUO ; Xiaoyan WANG ; Shourong SHEN
Journal of Central South University(Medical Sciences) 2016;41(4):440-444
Crohn's disease (CD) is a nonspecific chronic intestinal inflammatory disease with unknown etiology. The course of CD is persistent and recurrent. In the progress, CD can come with many complications such as obstruction, fistula formation, perforation, and hemorrhage. The early diagnosis, treatment, and the time of the surgery for CD pose a big controversy and challenge. There was a female patient diagnosed as Crohn's disease with severe complication in department of Gastroenterology of the Third Xiangya Hospital, Central South University. We reported the diagnosis and treatment on this patient. The choice for the medicine and surgury was discussed.
Crohn Disease
;
complications
;
diagnosis
;
therapy
;
Female
;
Humans
6.Effect of acupuncture-moxibustion on negative emotions and plasma tryptophan metabolism in patients with Crohn's disease at active stage.
Chun-Hui BAO ; Jie ZHONG ; Hui-Rong LIU ; Yu-Pei GU ; Pin WU ; Kan GU ; Di WANG ; Zhi-Jun WENG ; Yin SHI ; Huan-Gan WU
Chinese Acupuncture & Moxibustion 2021;41(1):17-22
OBJECTIVE:
To observe the effect of acupuncture-moxibustion on negative emotions and plasma tryptophan (Trip)-kynurenine (Kyn) metabolism in the patients with Crohn's disease (CD) at the mild and moderate active stage.
METHODS:
A total of 66 CD patients were randomized into an observation group (33 cases, 1 case dropped off) and a control group (33 cases, 2 cases dropped off). In the observation group, acupuncture was applied in combination with moxibustion. In the control group, the sham-acupuncture was used in combination with sham-moxibustion. In both of the observation group and the control group, acupuncture was applied to Zhongwan (CV 12), Shangjuxu (ST 37), Sanyinjiao (SP 6), Gongsun (SP 4), Hegu (LI 4), Quchi (LI 11), Taixi (KI 3) and Taichong (LR 3), and moxibustion was applied to Tianshu (ST 25) and Zusanli (ST 36). The treatment was given once every two days, 3 times a week, totally for 12 weeks. Separately, before and after treatment, the score of the hospital anxiety-depression scale (HADS) and the score of intestinal core symptoms (degree of abdominal pain and frequency of diarrhea) were observed in the patients of the two groups. The concentration of plasma indoleamine 2,3-dioxygenase 1 (IDO1) and the ratios of Kyn/Trp, QuinA/Kyn, KynA/Kyn and KynA/QuinA were compared between the two groups.
RESULTS:
Compared with before treatment, the scores of HADS-A and HADS-D in the observation group and the score of HADS-A in the control group were all reduced after treatment (
CONCLUSION
Acupuncture and moxibustion relieve the negative emotions of anxiety and depression in CD patients at mild and moderate active stage, which is probably related to the regulation of plasma Trp-Kyn metabolic pathway.
Acupuncture Points
;
Acupuncture Therapy
;
Crohn Disease/therapy*
;
Emotions
;
Humans
;
Moxibustion
;
Plasma
;
Treatment Outcome
;
Tryptophan
7.Clinical Characteristics at Diagnosis and Course of Korean Patients with Crohn's Disease.
Jong Beom PARK ; Suk Kyun YANG ; Seung Jae MYUNG ; Jeong Sik BYEON ; Yun Jung LEE ; Gin Hyug LEE ; Hwoon Yong JUNG ; Weon Seon HONG ; Jin Ho KIM ; Young Il MIN
The Korean Journal of Gastroenterology 2004;43(1):8-17
BACKGROUND/AIMS: The aim of this study was to evaluate the clinical characteristics and course of Korean patients with Crohn's disease (CD). METHODS: A total of 113 patients who were newly diagnosed as having CD at the Asan Medical Center between October 1989 and December 2001 were included. RESULTS: The male to female ratio was 1.9:1 and the mean age at diagnosis was 24.2 +/- 7.8 years. The disease location was the small bowel in 19.5%, the large bowel in 11.5%, and the both small and large bowels in 69.0% of the patients. Empirical anti-tuberculous medications were administered to 53 cases (46.9%). Major complications of CD were intestinal obstruction (25.7%) and perianal fistula (42.5%). The cumulative remission rate was 75.7% at 1 year and 80.7% at 3 years from diagnosis. The cumulative relapse rate was 30.7% at 1 year and 53.0% at 3 years from remission. The cumulative operation rate was 11.5% at 1 year and 13.1% at 3 years from diagnosis. CONCLUSIONS: There are no differences in the remission and recurrence rates between Korean and Western patients with CD. Although the cumulative operation rate seems to be lower in Korea than in Western countries, the cause of the difference is uncertain. Further studies are needed to determine the characteristics of CD in Korea.
Adolescent
;
Adult
;
Crohn Disease/complications/*diagnosis/therapy
;
English Abstract
;
Female
;
Humans
;
Korea
;
Male
;
Remission Induction
8.Long-term Efficacy and Predictors of Response to Infliximab in Korean Patients with Crohn's Disease.
The Korean Journal of Gastroenterology 2013;61(5):241-242
No abstract available.
Antibodies, Monoclonal/*therapeutic use
;
Crohn Disease/*drug therapy
;
Female
;
Gastrointestinal Agents/*therapeutic use
;
Humans
;
Male
9.Therapeutic Efficacy of Oral Enteral Nutrition in Pediatric Crohn's Disease: A Single Center Non-Comparative Retrospective Study.
Hyun Jin KIM ; Young KIM ; Jin Min CHO ; Seak Hee OH ; Kyung Mo KIM
Yonsei Medical Journal 2016;57(5):1185-1191
PURPOSE: Exclusive enteral nutrition (EEN) therapy effectively induces clinical remission in Crohn's disease (CD). It remains unclear, however, whether partial enteral nutrition (PEN) can maintain remission. This study was performed to determine the abilities of oral EEN and oral PEN to induce and maintain clinical remission in pediatric patients with CD, respectively. MATERIALS AND METHODS: Pediatric patients with CD who received oral EEN at a single center in 2000-2014 were identified retrospectively. Remission rates of the EEN and PEN during the 2 years study period were determined. Risk factors for EEN and PEN failure were identified. RESULTS: Of the 66 patients who started EEN, 61 (92%) completed the course. Clinical remission was achieved in 88% (58/66) of the patients. All 58 patients with remission continued with PEN: 43 (74%) were treatment adherent. The cumulative remission rates at 1 and 2 years were 67% and 52%, respectively. Differing from EEN, limited therapeutic efficacy of PEN was shown in severe CD patients. Female gender associated significantly with non-adherence. CONCLUSION: Oral EEN and PEN effectively induced and maintained remission in a pediatric population. Non-adherence was a limiting factor in the success of therapy.
Adolescent
;
Child
;
Crohn Disease/*therapy
;
Enteral Nutrition/*methods
;
Female
;
Humans
;
Male
;
Remission Induction
;
Retrospective Studies
10.Effect of Short-Term Partial Enteral Nutrition on the Treatment of Younger Patients with Severe Crohn's Disease.
Yunkoo KANG ; Seung KIM ; Sang Yong KIM ; Hong KOH
Gut and Liver 2015;9(1):87-93
BACKGROUND/AIMS: To analyze the effect of short-term supportive temporary partial enteral nutrition therapy for treating severe pediatric Crohn's disease (CD). METHODS: We conducted a prospective, open-label study in pediatric patients with CD (n=78) from January 2007 to December 2011. The CD patients were divided into three groups according to disease severity (mild, moderate, and severe). Seventeen patients with severe CD received short-term partial enteral nutrition (SPEN) in addition to their general diet for 4 weeks after the induction of remission with medical treatment. This SPEN group was further divided into two groups by age (<13 years, > or =13 years). Nutritional parameters and Pediatric Crohn's Disease Activity Index scores were analyzed at the initial enrollment and following 1 year of treatment for all groups. RESULTS: Nutritional status improved substantially after 1 year of treatment in the severe CD group. Nutritional status in the SPEN group improved considerably more than that in the non-SPEN group. Additionally, the <13-year-old group demonstrated better nutritional status improvement than the > or =13-year-old group. CONCLUSIONS: SPEN may be effective in pediatric patients with severe CD for improving nutritional status and moderating disease severity.
Adolescent
;
Crohn Disease/*therapy
;
*Enteral Nutrition/methods
;
Female
;
Humans
;
Male
;
Nutritional Status
;
Prospective Studies
;
Treatment Outcome