No abstract available.
Creatinine*

No abstract available.
Creatinine* ; Plasma*

No abstract available.
Creatinine* ; Humans

Creatinine (Cr) is a representative biomarker reflecting renal function. In this study, we compared serum Cr levels using Roche Modular D (Roche Diagnostics, Germany), Roche Cobas 8000 c702 (Roche Diagnostics), and AU5800 (Beckman Coulter, USA). In addition, we assessed the differences in Cr measurements using the Jaffe and enzymatic methods.METHODS: Precision, linearity, and methods were evaluated in accordance with CLSI guidelines. Serum Cr was measured by Modular D following the Jaffe method, and serum Cr was measured by Cobas 8000 c702 and AU5800, following the Jaffe and enzyme methods.RESULTS: All of the total coefficients of variations (CVs) were below 5%. Linearity was observed in the performance ranges evaluated (r>0.99, slope: 0.965 and 0.955). When Modular D and Cobas 8000c 702 were compared, the slope and y-intercept were 0.9928 (95% confidence interval [CI]: 0.9802 to 1.000) and -0.0156 (95% CI: −0.0200 to −0.0054), respectively. The slope and y-intercept were 0.9811 (95% CI: 0.9570 to 0.9951) and -0.0484 (95% CI: −0.0638 to −0.0297) when Modular D and Au5800 were compared. Serum Cr measured by Cobas 8000 c702 and AU5800 using the Jaffe method were 3.2% and 6.9% lower than the values measured by Modular D, respectively. Both Modular D and Cobas 8000 c702 showed acceptable accuracies.CONCLUSIONS: Serum Cr measurements using Cobas 8000 c702 and AU5800 were comparable to those measured by Modular D, and showed satisfactory precision and linearity; thus, these techniques could be useful for clinical laboratories.]]>
Creatinine ; Methods

Serum creatinine has been widely used clinically as an important index for kidney function. Kinetic Jaffe assay is used for serum creatinine analysis at about 80% of clinical laboratories in Korea. There are two major interferences when creatinine level is measured by kinetic Jaffe method. One is Jaffelike chromogen, which causes positive interference, and the other is bilirubin that creates negative interference. Positive interference created by Jaffelike chromogen can be easily corrected by subtracting 0.3 mg/dL (arithmetic compensation), which is average interference by Jaffelike chromogen in normal serum, from the measured creatinine value by kinetic Jaffe method. The interference created by bilirubin can be eliminated by rate blanking which corrects the rate of change in absorbance by bilirubin from the absorbance change by Jaffe reaction. Compensated rate-blanked Jaffe kinetic assay employs above two major corrections. In clinical laboratories currently using kinetic Jaffe Method, simple application of "compensated rate-blanked Jaffe kinetic assay" can determine serum creatinine values that minimizing major interferences without change of reagent.
Bilirubin ; Creatinine ; Kidney ; Korea

The research studied urinary beta2-microglobulin excretion to detect tubular dysfunction in 31 patients with primary nephrotic syndrome. The result showed the increased excretion of beta2-microglobulin was observed in 11/31 cases. There were no sighgicant differences of the urinary creatinine excreation and between group of patients with increased urinary beta2-microglobulin excretion and the group without it. This indicated having combine tubular dysfunction in patients with primary nephrotic syndrome. The finding might suggest the use of urinary beta2-microglobulin for detecting the associated tubular disfuntion in such patients
Diagnosis ; Creatinine ; Beta-Globulins

Extracorporeal shock wave lithotripsy(ESWL) has become a major treatment modality for symptomatic renal stone disease. Although ESWL was proved to be effective in disintegrating stones it is known that some radiological evidence of transient renal malfunction could be possible after ESWL. However. it has been difficult to assess the renal damage quantitatively. We evaluated several basic physiologic parameters namely, total protein excretion, creatinine clearance and beta-2-microglobulin excretion in aliquots of 24 hour urine samples. ESWL was performed using Siemens Lithostar device. In a total of. 33 patients urine samples were obtained before, 1 day and 7 days after ESWL without prior manipulation. Our data showed that transient increased protein excretion and decreased creatinine clearance occur immediately after treatment, and return to pre-procedure levels within 7 days without a change in beta-2-microelobulin excretion after ESWL. Conclusively, renal damage induced by ESWL is thought to be transient and of limited magnitude of brief duration.
Creatinine ; Humans ; Lithotripsy* ; Shock*

No abstract available.
Creatinine* ; Kidney Failure, Chronic*

Extracorporeal shock wave lithotripsy (ESWL) is chosen as a primary treatment modality due its non-invasiveness and high effectiveness. But renal damage is reported in 65-85% of patients with renal stone after ESWL. It is Know that the renal collecting tubular enzyme, N-acety1-glucosaminidase (NAG), is increased in urine and 3-4 weeks are needed to be normal in most patients in case of damage by ESWL. Nevertheless, ESWL is performed repeatedly with 1 or 2 weeks interval and moreover daily without checking the renal damage in most ESWL centers. So, this study is performed to know how severely the renal damage is caused by ESWL and to know the safe interval of ESWL in patients with renal stones. We measured the urinary NAG/Creatinine ratio to check the renal damage in 9 patients with renal stone after repeated ESWL (19kV, 2000-3000 shock wave/session) using Lithostar Ultra manufactured by Siemens. The results are as follows; 1. In 3 patients who received ESWL once a day for 2 days repeatedly, one patient had normal urinary NAG/Creatinine ratio, one patient had rapidly increased urinary NAG/Creatinine ratio immediately and the ratio decreased from two weeks later and it needed 4 weeks to be normal. The other one patient had rapidly increased urinary NAG/Creatinine ratio immediately and the ratio was normal 1 week later. 2. All 6 patients who received ESWL with one or two weeks interval had normal urinary NAG/ Creatinine ratio. In conclusion, it is thought that repeated ESWL by Lithostar Ultra (Siemens) with more than 1 week interval is safe. In case of repeated ESWL more than 3 times with one day interval, it is needed to confirm the normal urinary NAG/Creatinine ratio before procedure.
Creatinine ; Humans ; Lithotripsy* ; Shock*

Creatinin level in control group was 93.55 ± 10.96 micromol/l. This level in exposed group was 114.03 ± 9.72 micromol/l. Renal creatinin clearance control group was 81.0 ± 4.0 micromol/l and in exposed group was 70.71 ± 9.0 micromol/l. There was not a relationship between hair lead level and renal creatinin and renal clearance but the length of service clearly influenced creatinin level and renal clearance
Creatinine ; Kidney ; Hair