No abstract available.
Creatine Kinase* ; Electrophoresis*

Creatine Kinase ; Humans

Serum creatine phosphokinase(CPK) levels were measured serially in 20 adults with closed tibial shaft fractures, CPK activity increased significantly after fracture(p < 0.01). High energy and delayed healing fractures had significantly higher levels of CPK than low energy and normally healing fractures, respectively. Thus, CPK determinations could be used to assess the severity of trauma and possible prognosis of the healing in tibial shaft fractures.
Adult ; Creatine Kinase ; Creatine ; Humans ; Prognosis

No abstract available.
Creatine Kinase ; Hypothyroidism* ; Muscular Diseases

During a 3 month period in 1984, 12 patients undergoing scheduled valvular replacement were Studied by CK and CK-MB isoenzyme to evaluate the myocardial damage during open heart operation. Total creatine kinase value was 58.3+/-25.6 u/L at control, 59.8+/-23.5 u/L at prebypass period, 85.5+/-49.6 U/L at during bypass period, 20.2+/-87.6 at postbypass period respectively. It began to rise in prebypass period and showed higtest level in postbypass period. CK-MB value was low in most cases below 20 U/L but in 2 patients postbypass period showed high level which above 40U/L. Initial isoenzyme activity was detected in 2 patients prior to anesthesia, in 2patients prior to bypass, in 5 patients during bypass, and in all others after termination of bypass. Considering above data we concluded that anesthetic management during prebypass period and myocardial preservation during bypass period required more proper and aggressive management despite of good operation results.
Anesthesia ; Creatine Kinase* ; Creatine* ; Heart ; Heart Valve Diseases* ; Humans

This study was conducted to evaluate the postnatal changes of serum creatine kinase (CK) and its isoenzymes in normal and asphyxiated newborns. In normal newborns total CK, CK-MM and CK-MB reached a plateau between 2 and 24 hr after birth whereas the serum CK-BB remained stable after birth. CK-MM, CK-MB and CK-BB respectivily composed 90~94%, 5~7% and 1~5% of total CK during study period. In asphyxiated newborns total CK, CK-MM and CK-MB reached maximal value at 12 hr after birth whereas CK-BB decreased after birth. There were no significant differences between normal and asphyxiated newborns in total CK, CK-MM and CK-MB during study period (up to 24 hrs after birth). But CK-BB of asphyxiated newborn was elevated significantly (p<0.05) within 6 hrs after birth compared to normal newborns. There were no significant differences of CK and its isoenzymes between patients evaluated by 5 min Apgar scores(0~3, 4~6 and 7~10) or degree of HIE (HIE stage 0~I, II and III). According to these results, the serum CK-BB is elevated in asphyxiated newborns during 1st 6hrs after birth but has no predictive values of the extent of cerebral damage.
Creatine Kinase* ; Creatine* ; Humans ; Infant, Newborn* ; Isoenzymes ; Parturition

No abstract available.
Child* ; Creatine Kinase* ; Creatine* ; Epilepsy* ; Humans ; Liver* ; Prospective Studies*

The study included 112 patients with diagnosis of DMD at National Institute of Pediatrics and 24 patient’s brothers. The results showed that: value of definitive diagnosis of creatine kinase (CK) test were 100% (CK levels of 100% patients were higher than CK levels of normal children). CK method could detect very early DMD even patients who were not yet clinical expression (11/24 patient’s were not yet clinical expression detected DMD by CK). The value of CK for heterozygote detection was 82.3% for DMD patient’s mothers who had clearly family history and 35.3% for DMD patient’s mothers who had only one child with DMD in the family. Based on PCR result analysis, gene mutation of two DMD patient with clearly family history had not belonged to 48- exon.
diagnosis ; Creatine Kinase ; Heterozygote ; Muscular Dystrophy, Duchenne

STUDY DESIGN: A retrospective study OBJECTIVES: To evaluate postoperative muscle damage after microendoscopic discectomy (MED) and open discectomy (OD), using analysis of serum creatine phosphokinase (CPK) levels. SUMMARY OF LITERATURE REVIEW: Paravertebral muscle damage after retraction during posterior lumbar surgery can cause postoperative back pain. Serum CPK level is elevated in these patients and may indicate postoperative muscle damage. MATERIALS AND METHODS: We examined 35 cases with MED (group 1) and 11 cases with OD (group 2). Serum CPK levels were checked preoperatively and postoperatively at day 1 and day 3. We analyzed intra-group and inter-group differences in CPK levels according to sex, age, and operation time. Surgical outcomes were evaluated with a visual analog scale (VAS) preoperatively and 1 year postoperatively. RESULTS: CPK levels at postoperative 1 day were increased significantly and decreased significantly at postoperative 3 day in both groups (p<0.05), with levels in group 1 significantly lower than in group 2 (p<0.05). There were no differences in CPK levels according to sex, age, or operation time, except between the 3rd and 5th decades of age at postoperative 1 day in group 2. VAS was significantly different in intra-group analysis (p<0.05) with no significant differences in intergroup analysis. CONCLUSIONS: MED induced a lower increase in serum CPK than OD with similar VAS outcomes. MED results in less postoperative muscle damage than OD, with similar surgical outcomes.
Back Pain ; Creatine Kinase* ; Creatine* ; Diskectomy* ; Humans ; Retrospective Studies ; Visual Analog Scale

OBJECTIVES: This prospective study was designed to investigate the effect of serotonergic atypical antipsychotics on serum creatine phosphokinase. METHOD: The subjects were 60 inpatients who were medicated risperidone and nemonapride, atypical antipsychotics. The symptoms of NMS such as fever and muscle rigidity and the level of CRK of all subjects were assessed on the 5th, 10th, 20th, and 30th medication day. RESULTS: Sociodemographic variables, such as sex and mean age and number of intramuscular injection were not different between the risperidone and the nemonapride group. Maximum dosage of antipsychotics (chlorpromazine equivalent) was significantly higher in the nemonapride group. Fever and muscle rigidity were not different between two groups (p>0.05). The change of serum creatine phosphokinase was significantly higher in the risperidone group than the nemonapride group (p<0.05). CONCLUSIONS: Serum CRK showed a significant increase in risperidone than nemonapride group. Such a finding is primarily caused by the effect of atypical antipsychotics mediating serotonergic effects. It is not recommanded to stop the medication by misunderstanding the effect as a prodrome symptom of NMS.
Antipsychotic Agents* ; Creatine Kinase* ; Creatine* ; Fever ; Humans ; Injections, Intramuscular ; Inpatients ; Muscle Rigidity ; Negotiating ; Prospective Studies ; Risperidone*