Serum creatine phosphokinase(CPK) levels were measured serially in 20 adults with closed tibial shaft fractures, CPK activity increased significantly after fracture(p < 0.01). High energy and delayed healing fractures had significantly higher levels of CPK than low energy and normally healing fractures, respectively. Thus, CPK determinations could be used to assess the severity of trauma and possible prognosis of the healing in tibial shaft fractures.
Adult ; Creatine Kinase ; Creatine ; Humans ; Prognosis

No abstract available.
Creatine Kinase* ; Electrophoresis*

Creatine Kinase ; Humans

During a 3 month period in 1984, 12 patients undergoing scheduled valvular replacement were Studied by CK and CK-MB isoenzyme to evaluate the myocardial damage during open heart operation. Total creatine kinase value was 58.3+/-25.6 u/L at control, 59.8+/-23.5 u/L at prebypass period, 85.5+/-49.6 U/L at during bypass period, 20.2+/-87.6 at postbypass period respectively. It began to rise in prebypass period and showed higtest level in postbypass period. CK-MB value was low in most cases below 20 U/L but in 2 patients postbypass period showed high level which above 40U/L. Initial isoenzyme activity was detected in 2 patients prior to anesthesia, in 2patients prior to bypass, in 5 patients during bypass, and in all others after termination of bypass. Considering above data we concluded that anesthetic management during prebypass period and myocardial preservation during bypass period required more proper and aggressive management despite of good operation results.
Anesthesia ; Creatine Kinase* ; Creatine* ; Heart ; Heart Valve Diseases* ; Humans

This study was conducted to evaluate the postnatal changes of serum creatine kinase (CK) and its isoenzymes in normal and asphyxiated newborns. In normal newborns total CK, CK-MM and CK-MB reached a plateau between 2 and 24 hr after birth whereas the serum CK-BB remained stable after birth. CK-MM, CK-MB and CK-BB respectivily composed 90~94%, 5~7% and 1~5% of total CK during study period. In asphyxiated newborns total CK, CK-MM and CK-MB reached maximal value at 12 hr after birth whereas CK-BB decreased after birth. There were no significant differences between normal and asphyxiated newborns in total CK, CK-MM and CK-MB during study period (up to 24 hrs after birth). But CK-BB of asphyxiated newborn was elevated significantly (p<0.05) within 6 hrs after birth compared to normal newborns. There were no significant differences of CK and its isoenzymes between patients evaluated by 5 min Apgar scores(0~3, 4~6 and 7~10) or degree of HIE (HIE stage 0~I, II and III). According to these results, the serum CK-BB is elevated in asphyxiated newborns during 1st 6hrs after birth but has no predictive values of the extent of cerebral damage.
Creatine Kinase* ; Creatine* ; Humans ; Infant, Newborn* ; Isoenzymes ; Parturition

No abstract available.
Child* ; Creatine Kinase* ; Creatine* ; Epilepsy* ; Humans ; Liver* ; Prospective Studies*

No abstract available.
Creatine Kinase ; Hypothyroidism* ; Muscular Diseases

The study included 112 patients with diagnosis of DMD at National Institute of Pediatrics and 24 patient’s brothers. The results showed that: value of definitive diagnosis of creatine kinase (CK) test were 100% (CK levels of 100% patients were higher than CK levels of normal children). CK method could detect very early DMD even patients who were not yet clinical expression (11/24 patient’s were not yet clinical expression detected DMD by CK). The value of CK for heterozygote detection was 82.3% for DMD patient’s mothers who had clearly family history and 35.3% for DMD patient’s mothers who had only one child with DMD in the family. Based on PCR result analysis, gene mutation of two DMD patient with clearly family history had not belonged to 48- exon.
diagnosis ; Creatine Kinase ; Heterozygote ; Muscular Dystrophy, Duchenne

Dermatomyositis (DM) is an idiopathic inflammatory myopathy (IIM) characterized by skeletal muscle inflammation and typical skin manifestations. Creatine kinase (CK) has traditionally been considered to be the most useful serum enzyme for the diagnosis and assessment of adult patients with IIM. To our knowledge, there has been no reported case of biopsy-proven DM without CK elevation in Korea, to date. Panniculitis is an uncommon cutaneous manifestation in adult patients with DM. A search of the PubMed database reveals fewer than 30 reported cases of panniculitis in adult patients with DM. Here, we report a case of a 42-year-old female who was diagnosed with biopsy-proven DM with normal serum CK levels and panniculitis.
Adult ; Creatine Kinase* ; Creatine* ; Dermatomyositis* ; Diagnosis ; Female ; Humans ; Inflammation ; Korea ; Muscle, Skeletal ; Myositis ; Panniculitis ; Skin Manifestations

A retrospective study was conducted to evaluate the changes in serum creatine kinase (CK) and lactic dehydrogenase (LDH) after coronary artery bypass grafting surgery. We studied 37 patients who had normal liver and kidney functions and who did not have the perioperative acute myocardial infarction. After measuring total serum LDH and isoenzyme 1 to 5, and seum CK and isoenzyme CK-MB, we compared pastoperative values to preoperative value. We also calculated the ratio of LD1 to LD2 (LD1 /LD2). Total LDH increased for postoperative 0 day, 1 day, 2 day, and 4 day. LD1, LD2 LD3 and LD4, increased for postoperative 0 day, 1 day, and 2 day, but LD5 increased for 0 day and 1 day. Total CK increased for 0 day, 1 day, and 2 day, but CK-MB did not increase postoperatively. LD1/LD2 increased at posoperative 2 day. Among the total 113 samples, the number of the cases of LD1/LD2 > 1 is 12.
Coronary Artery Bypass ; Creatine Kinase* ; Creatine* ; Humans ; Kidney ; Liver ; Myocardial Infarction ; Oxidoreductases* ; Retrospective Studies