No abstract available.
Adrenocorticotropic Hormone* ; Cortisone* ; Epinephrine*

One case of fungus infection of the cornea, which led to enucleation, is reported. The fungus of Fusarium species was demonstrated on culture media and microscopic examination. The necessary for awareness of mycotic infections of the cornea, especially in antibiotic or/and cortisone topical treated eyes, is stressed.
Cornea ; Cortisone ; Culture Media ; Fungi ; Fusarium*

Authors report a rare case of localized osteonecrosis occuring in the medial femoral condyle induced by prolonged steroid administration in a 48 years old male who had kidney transplantation surgery. Initially, he experienced clinical symptoms of discomfort and recurring effusion of both knees after transplantation surgery which did not respond, at all, to conservative treatment even in its early stage.
Cortisone ; Humans ; Kidney Transplantation ; Knee ; Male ; Osteonecrosis

Chemotherapy-Oncologic Procedure ; Tuberculosis ; Cortisone ; Child

The present study was carried out to examine the effect of "Cortisone" on the worm burden migrated in the organs, and granulomatous change in the liver of mice infected with Toxocara canis eggs. Daily does of 0.5 mg "Cortisone" was administrated subcutaneously to Toxocara-infected mice with different schedule. The results are summarized as follows: More number of Toxocara larvae migrated into the muscle tissue, especially into the carcass through the wall of the large intestine and higher distribution rate and longer persistence of worms were also recognized in the carcass of the experimental group than in the control. Cortisone administration resulted the inhibition of granuloma formation, as well as the resolution of granuloma in the liver. However, the discontinuation of the administration induced the reccurence of heavier grade of inflammation. In non-cortisone treated group (control), cellular infiltration appeared around the worms in the liver on the 10th day of the infection, and typical granulomatosis was followed on the 20th day. As in above results, it is considered cortisone has remarkable anti-inflammatory and immunosuppressive effects in mice infected with T.canis, but histopathological changes on the granuloma formation might be related closely with the duration of Toxocara infection, dosage, duration and timing of cortisone administration.
parasitology-helminth-nematoda-Toxocara canis ; liver ; mouse ; cortisone

Effect of cortisone on renal tuberculosis induced experimentally in rabbit and influence of the hormone on the effect of anti-tuberculous agents have been studied. Tubercle bacilli, bovine 123 strain. was inoculated into the rabbit kidneys to induce renal tuberculosis. In one group (A) bacilli were inoculated into the left kidney and into the both kidneys in another group (B). Treatments were started on the 10th post-inoculation day in the former group and on the 50th day in the latter group. Rabbits were divided into four experimental groupsas follows and treatments were continued for one month. After one week of observation animals were sacrificed and kidneys. lunge, livers, spleens and lymphnodes were studied on their tuberculous changes.1. Control. no treatment.2. Injection with cortisone acetate 10mg3. Injection with streptomycin 100mg. and INAH 23.6 mg.4. Injection with streptomycin 100mg. INAH 23.6 mg. and cortisone acetate 10mg.The animals were weighed and tubercle bacilli in the urine were studied every week during the experiment. The following results were obtained: 1) Body weight. Comparing with the control, animals receiving cortisone revealed marked decrease in body weight, while animals receiving anti-tuberculous agents increased their body weights. The animals receiving both cortisone and anti-tuberculous agents showed a decrease in body weight. 2) Urinary tubercle bacilli. After 4 weeks of inoculation, the bacilli were positive in urine. The control and the cortisone receiving animals in both groups A and B manifestated positive bacilli in urine and animals in group A receiving anti-tuberculous agents and both cortisone plus anti-tuberculous agents showed no bacilli in urine. In group B, bacilli were positive in animals receiving anti-tuberculous agents or both cortisone plus anti-tuberculous agents after 30 days of treatment. 3) Tuberculin test. Tuberculin test was weakened or negative after administering cortisone in tuberculous animals 4) Pathological histology. In group A, there was no significant changes between the control and the animals with cortisone. All showed wide-spread tuberculous lesions. Very slight changes were observed in animals receiving anti-tuberculous agents or both anti-tuberculous agents and cortisone, and the lesion showed improvement. Microscopically, animals receiving both anti-tuberculous agents and cortisone revealed cloudy swelling and simple necrosis throughout but no cellular infiltration in the kidney tissue. The affect of treatment was more apparent than in the animals receiving only anti-tuberculous agents. In the group B, lesions in the animals receiving cortisone was more marked than in the control animals. Macroscopically, no significant changes were observed both in the animals receiving cortisone and anti-tuberculous agents, and ones receiving only anti-tuberculous agents. However, microscopically, the former animals showed less fibrosis and calcification than the latters. Dissemination of tuberculous lesion to other organs was not influenced by administration of cortisone but prohibited by anti-tuberculous agents.
Animals ; Body Weight ; Cortisone* ; Fibrosis ; Kidney ; Liver ; Lung ; Necrosis ; Rabbits ; Spleen ; Streptomycin ; Tuberculin Test ; Tuberculosis, Renal*

The mycotic flora of the conjunctival sac was investigated in the following fhie groups: Group I: Control group: 60 cases. Group II: Children group (3 to 4 years of age): 80 eyes. Group III: Young adult group (40 to 70 years of age): 60 eyes. Group IV: Old aged group(40 to 70 years of age): 60 eyes. Group V: Young adult group treated with 0.5% cortisone acetate solution and 0.5% chloramphenicol solution, q.i.d., for three weeks: 104 eyes. Conjunctival stroke was made at the lower conjunctival fornix of each eye and inoculated on Sabouraud's glucose media. In group I. the cotton stick was not contacted with the conjunctiva, but the similar procedure was performed, as in the other groups, remaining in the air for the same duration to rule out air contamination. The fungi cultured for at least four weeks were identified by macroscopic appearance the colonies and microscopic findings of the mycelia and spores. The following results were obtained: 1) No positive culture was noted in Group I. This will rule out contamination during the procedure. 2) Positive cultures were observed in 16.2% of normal adults, and in 6.2% of normal children. 3) In steroid and antibiotic treated group, the incidence of positive cultures increased to 31.7%. 4) The fungi cultured were identified as the following eight species: Penicllium sp., Aspergillus sp., Mycelia sterila., Hormodendrum sp., Mucor sp., Cephalosporium sp., and Oospora sp.
Acremonium ; Adult ; Aspergillus ; Child ; Chloramphenicol ; Conjunctiva* ; Cortisone ; Fungi ; Glucose ; Humans ; Incidence ; Mucor ; Spores ; Stroke ; Young Adult

BACKGROUND: The purpose of this study was to verify the effects of music therapy on subjective stress response, salivary cortisol and fatigue for nurses working in intensive care unit (ICU). METHODS: This study employed non-equivalent control group pretest–posttest design on quasi experimental basis. Subjects were 52 nurses (26 experimental and control group respectively) who have been working at ICU of Gil Hospital in Incheon, Korea. Data were collected from August 4 to October 6, 2014. Experimental group have listened to their 4-7 favorite musics individually once for 30 minutes after day-work. RESULTS: In experimental group, subjective stress response (t=5.02, P<0.001), salivary cortisol (t=2.08, P=0.042), and fatigue (t=5.66, P<0.001) have decreased significantly comparing to the control group. CONCLUSIONS: This study has confirmed especially through objective physiological index of salivary cortisol that listening the favorite music for nurses in ICU was an effective and objective managerial measure to resolve their job stress and fatigue.
Cortisone ; Critical Care* ; Fatigue* ; Hydrocortisone* ; Incheon ; Intensive Care Units ; Korea ; Music Therapy* ; Music*

PURPOSE: Frequent changes in chronic urticaria (CU) activity over time can cause psychological stress, which also serves as a trigger of CU. To measure the control status of CU, the Urticaria Control Test (UCT) was developed in Germany. This study aimed to investigate the validity, reliability and responsiveness to changes in CU for the Korean version of the UCT (K-UCT) and its relation with salivary cortisol and cortisone levels. METHODS: Linguistic adaptation of the UCT into Korean was conducted. A total of 96 CU patients were enrolled, and 80 of them completed the study. The K-UCT and other outcome scores for CU were measured and repeated after 4 weeks of treatment. Control status was classified by physicians into well-controlled, partly-controlled, and uncontrolled CU. Salivary cortisol and cortisone were measured by liquid chromatography-tandem mass spectrometry. RESULTS: Excellent internal consistency and intra-class reliability were obtained. Strong correlations between the K-UCT and disease severity, reflected in the Urticaria Activity Score (UAS)/global assessment of urticaria control by physicians/patient assessment of symptom severity/CU-specific quality of life were noted. K-UCT scores ≥12 were found to be optimal for determining well-controlled CU (sensitivity, 75.0%; specificity, 758%; area under the curve, 0.824). Perceived stress scale scores were significantly correlated with the UAS and the K-UCT. Salivary cortisone levels were significantly correlated with K-UCT (r = 0.308, P = 0.009) and differed significantly according to control status determined by a K-UCT ≥12. CONCLUSIONS: This study demonstrated that the K-UCT can be a valid instrument with which to gauge CU control status in Korean patients. Further studies are needed to validate salivary cortisone as a biomarker for CU control.
Cortisone* ; Germany ; Humans ; Hydrocortisone ; Korea ; Linguistics ; Mass Spectrometry ; Quality of Life ; Sensitivity and Specificity ; Stress, Psychological ; Urticaria*

Since almost all patients suffering from acute hematogenous osteomelitis, due to Staph. aureus, are under 20 year old, it may be assumed that the host-parasite relationships, between the young and actively growing bodies and the organisms, might be somewhat different from the ones prevailed in the adult bodies. And it is also known that the administration of various hormones may produce significant influences upon the susceptibity and resistance of host. It was thought worthwile to study the host reactions to the introduction of organisms and the effects of cortisone or prehormone administration to the infected animals. Thus, ca. 5×10⁷ viable cells of Staph. aureus were inoculated i.v. into young rabbits, weighing 1–1.5 kg., of around 2 months old. The number of viable units of Staph. aureus were followed in the circulating blood and urine of the inoculated animals with or without treatment of cortisone or prehormone. The results of observations might be summerized as follows: 1. The organisms were removed rapidly from the circulating blood of infected rabbits without treatment. The number of viable units increased more or Iess slowly, peak being three to eight days after inoculation, in the urine of infected rabbits without treatment. 3. In the of infected rabbits with daily administration of cortisone, small number of organisms could be cultured throughout the 17 days of observation. 4. The number of viable units in the urine of infected rabbits with daily adminstration of cortisone sho wed significant increase upon the onset of cortisone administration and then decreased slowly. 5. Prehormone administration appeared to produced no significant influence on the number or viable stapylococci in the blood and urine of infected rabbits.
Adult ; Animals ; Cortisone ; Host-Parasite Interactions ; Humans ; Rabbits ; Staphylococcus aureus ; Staphylococcus