Coronary Disease ; etiology ; psychology ; Humans

Coronary Disease ; etiology ; Humans ; Hypertriglyceridemia

Angioplasty, Balloon, Coronary ; Coronary Artery Disease ; etiology ; Coronary Disease ; etiology ; Humans ; Inflammation ; complications ; Microvascular Angina ; etiology ; Myocardial Ischemia ; etiology

Literatures have demonstrated the association between oral diseases and systemic diseases. For example, periodontitis is associated with coronary heart disease, diabetes, preterm low birth weight, and gastritis. Therefore, more relevant research on the relationship between oral diseases and systemic diseases should be carried out.
Coronary Disease ; etiology ; Diabetes Mellitus ; etiology ; Gastritis ; etiology ; Humans ; Periodontitis ; complications ; Premature Birth ; etiology

Cardiomyopathy, Hypertrophic ; etiology ; pathology ; physiopathology ; Coronary Angiography ; Coronary Disease ; complications ; physiopathology ; Coronary Vessel Anomalies ; etiology ; pathology ; physiopathology ; Humans ; Myocardium ; pathology

Cogan’s syndrome (CS) is a rare inflammatory disorder characterized by interstitial keratitis and vestibuloauditory abnormalities often associated with various systemic manifestations. Involvement of cardiovascular system resembling systemic vasculitis may lead to severe complications and death. The present report describes a case of a female patient with atypical Cogan's syndrome presented with systemic manifestations and severe coronary and femoral artery stenosis. Despite the clinical improvement after glucocorticoids and cyclophosphamide, the patient required double aortocoronal bypass grafting one year letter. During three years follow-up, she was in stable condition, without stenocardial symptoms and claudication and her inflammatory parameters remain normal. This case highlights the rare involvement of coronary arteries without associated large-vessel vasculitis of the aortic arch in CS.
Adult ; Cogan Syndrome ; complications ; Coronary Disease ; etiology ; Female ; Humans

Animals ; Cardiovascular Diseases ; etiology ; Coronary Disease ; etiology ; Humans ; Hydrogen Sulfide ; metabolism ; Hypertension ; etiology ; Hypertension, Pulmonary ; etiology ; Myocardial Reperfusion Injury ; etiology

Animals ; Arteritis ; complications ; immunology ; Coronary Artery Disease ; etiology ; pathology ; Coronary Vessels ; pathology ; Models, Animal ; Rabbits

Coronary heart disease is one of the most important causes of death in human, and consumes vast medical resources. Percutaneous coronary intervention (PCI) has been a significant breakthrough for its treatment. However, clinical application has been hampered by in-stent restenosis (ISR). Although drug eluting stent (DES) has reduced the occurrence of restenosis, incidence of ISR is still about 5% to 10%. The main reasons for restenosis after PCI are hyperplasia of vascular endothelial cells and smooth muscle cell migration. The exact mechanism of personalized differences in restenosis is not clear yet, but there may be a variety of risk factors. In addition to aging, smoking and diabetes, an increasing number of studies have found that genetic and epigenetic factors play an important role in ISR. In this article, authors have reviewed genetic and epigenetic factors on the progression of ISR, which may help to determine the genetic risk factors in patients with ISR after PCI.
Angioplasty, Balloon, Coronary ; methods ; Coronary Restenosis ; etiology ; genetics ; Disease Progression ; Epigenomics ; methods ; Humans ; Stents ; Treatment Outcome

Brugada Syndrome ; etiology ; physiopathology ; Coronary Artery Disease ; physiopathology ; Coronary Vasospasm ; physiopathology ; Electrocardiography ; Humans ; Male ; Middle Aged