2.The characteristics and value of spect myocardial perfusion imaging using dipyridamole in diagnosis of coronary artery disease
Journal of Medical Research 2007;47(2):44-50
Background: Coronary artery disease (CAD) is the most common cardiovascular disease in developing countries. CAD also called coronary heart disease, is a condition in which plaque (plak) builds up inside the coronary arteries. These arteries supply your heart muscle with oxygen-rich blood. Objective: The purpose of the study was to investigate the characteristics and value of gated SPECT MPI with Technetium - 99m sestamibi using dipyridamole stress in diagnosis of CAD. Subjects and method: One hundred and forty - six suspected or known CAD patients, mean age 65.2 \xb1 9.11, underwent gated SPECT MPI with technetium - 99m sestamibi using dipyridamole stress. These patients was performed coronary angiography. Results: Of 146 patients, 33.6% had no adverse reaction to intravenous dipyridamole and no fatal adverse events (myocardial infarction, death ... ) was reported. The most common adverse reactions were headache (49.3%), chest pain (40.4%). Aminophyline was administrated to 25.7% of 146 patients and complete relief of symptoms in 91.3% of these patients. The sensitivity for detection of CAD was 95.2 % and the specificity and accuracy were 78.6% and 91.1 %. When excluded the patients with previous MI, these values were 88.9%; 80.0% and 85.7% respectively. Among the coronary branches, the sensitivity was highest in diagnosis of LAD and highest specificity was LCX lesions. Conclusions: The Technetium - 99m sestamibi gated SPECT using dipyridamole stress is a safety and valuable technique for the detection of CAD. \r\n', u' \r\n', u'
Coronary Artery Disease/epidemiology
;
pathology
;
Dipyridamole/ administration &
;
dosage
4.Prevalence of Coronary Artery Fistula in a Single Center of China.
Yue-Ying PAN ; Gen CHEN ; Bin CHEN ; Han-Lin MU ; Yi-Qi CHENG ; He-Song ZENG ; Han-Xiong GUAN
Chinese Medical Journal 2018;131(12):1492-1495
5.Association of metabolic syndrome with coronary artery calcification.
The Korean Journal of Internal Medicine 2015;30(1):29-31
No abstract available.
Calcium/*analysis
;
Coronary Artery Disease/*epidemiology
;
Coronary Vessels/*chemistry
;
Female
;
Humans
;
Male
;
Metabolic Syndrome X/*epidemiology
;
Vascular Calcification/*epidemiology
6.Rationale, design, and baseline characteristics of Chinese registry in early detection and risk stratification of coronary plaques (C-STRAT) study.
Jun-Jie YANG ; Dong-Kai SHAN ; Lei XU ; Jun-Fu LIANG ; Zhao-Qian WANG ; Mei ZHANG ; Min LI ; Wen-Jie YANG ; Jian-Rong XU ; Yong-Gao ZHANG ; Li-Ming XIA ; Li-Hua WANG ; Hong-Jie HU ; Zhi-Gang YANG ; Tao LI ; Qi TIAN ; Xu-Dong LYU ; Yun-Dai CHEN
Chinese Medical Journal 2021;134(7):870-872
7.Impact of different obesity patterns on coronary microvascular function in male patients with non-obstructive coronary artery disease.
Ruo Nan WANG ; Ping WU ; Fei YAO ; Shi Hao HUANGFU ; Jun ZHANG ; Chu Xin ZHANG ; Li LI ; Hai Tao ZHOU ; Qi Ting SUN ; Rui YAN ; Zhi Fang WU ; Min Fu YANG ; Yue Tao WANG ; Si Jin LI
Chinese Journal of Cardiology 2022;50(11):1080-1086
Objective: This study sought to investigate the impact of different obesity patterns on coronary microvascular function in male patients with non-obstructive coronary artery disease. Methods: We retrospectively analyzed clinical data of male patients diagnosed with suspected coronary microvascular dysfunction (CMD) in the First Hospital of Shanxi Medical University between December 2015 and August 2021. All patients underwent the one-day rest and stress 13N-ammonia positron emission tomography myocardial perfusion imaging. Overall obesity was defined by body mass index (BMI) ≥28 kg/m2 and abdominal obesity was defined by waist circumference ≥90 cm. Hyperemic myocardial blood flow (MBF)<2.3 ml·min-1·g-1 or coronary flow reserve (CFR)<2.5 were referred as CMD. All patients were grouped based on their BMI and waist circumference. MBF, CFR, the incidence of CMD, hemodynamic parameters, and cardiac function were compared among the groups. Results: A total of 136 patients were included. According to BMI and waist circumference, patients were categorized into 3 groups: control group (n=45), simple abdominal obesity group (n=53) and compound obesity group (n=38). Resting MBF did not differ between groups (F=0.02,P=0.994). Compared with the control group, hyperemic MBF was significantly lower in the simple abdominal obesity and compound obesity groups ((2.82±0.64) ml·min-1·g-1, (2.44±0.85) ml·min-1·g-1 and (2.49±0.71) ml·min-1·g-1, both P<0.05, respectively). Hyperemic MBF was comparable among the groups of patients with obesity (P=0.772). CFR was significantly lower in the simle abdominal obesity group compared with the control group (2.87±0.99 vs. 3.32±0.62,P=0.012). Compared with the control group, CFR tended to be lower in the compound obesity group (3.02±0.91 vs. 3.32±0.62,P=0.117). The incidence of CMD was significantly higher in both the simple abdominal obesity and compound obesity groups than in the control group (62.3%, 52.6% vs. 22.2%, both P<0.01, respectively). Waist circumference was an independent risk factor for male CMD (OR=1.057, 95%CI: 1.013-1.103, P=0.011). Conclusions: In male patients with non-obstructive coronary artery disease, abdominal obesity is associated with decreased coronary microvascular function. Male patients with simple abdominal obesity face the highest risk of CMD.
Humans
;
Male
;
Coronary Artery Disease
;
Coronary Circulation/physiology*
;
Obesity, Abdominal
;
Retrospective Studies
;
Obesity/epidemiology*
;
Hyperemia
8.Direct Comparison between Brachial Pressure Obtained by Oscillometric Method and Central Pressure Using Invasive Method.
Sang Ho PARK ; Seung Jin LEE ; Jae Yun KIM ; Min Jeong KIM ; Ji Yeon LEE ; A Ra CHO ; Hyeok Gyu LEE ; Se Whan LEE ; Won Yong SHIN ; Dong Kyu JIN
Soonchunhyang Medical Science 2011;17(2):65-71
OBJECTIVE: The importance of central blood pressure evaluation for cardiovascular risk stratification has been emphasized. The aim of this study is to evaluate whether brachial blood pressure obtained by the oscillometric method accurately reflects central blood pressure. METHODS: The subjects consisted of 84 consecutive patients with suspected coronary artery disease who underwent cardiac catheterization. Central blood pressure was invasively measured in the origin of the left subclavian artery by using the fluid-filled system, and at the same time, brachial blood pressure in the left upper arm was measured by the oscillometric method. RESULTS: No significant difference was found between central systolic pressure and brachial systolic pressure (144.49+/-18.84 mmHg vs. 142.44+/-14.96 mmHg, P=0.063). Bland-Altman analysis accounted for only a small bias of +2.25 mmHg, and the limits of agreement were 24.15 mmHg and -19.65 mmHg. Central diastolic pressure was significantly lower than brachial diastolic pressure (75.80+/-8.74 mmHg vs. 86.70+/-10.48 mmHg, P<0.001). Bland-Altman analysis showed a significant bias of -5.45 mmHg, and the limits of agreement were 2.83 mmHg and -13.73 mmHg. CONCLUSION: These results indicate that central systolic pressure can be directly estimated from brachial systolic pressure using the noninvasive oscillometric method and observed biases seem to remain within the practical range. However, use of the brachial diastolic pressure and pulse pressure measured by the noninvasive oscillometric method is doubtful in clinical practice because of their large biases.
Arm
;
Bias (Epidemiology)
;
Blood Pressure
;
Cardiac Catheterization
;
Cardiac Catheters
;
Coronary Artery Disease
;
Humans
;
Oscillometry
;
Subclavian Artery
9.The Potential of Peripheral Venous Pressure as a Substitutional Hemodynamic Parameter of Central Venous Pressure in Hypovolemic Patients with Coronary Artery Disease.
Jong Hwa LEE ; Young Lan KWAK ; Young Jun OH ; Helen Ki SHINN ; Seung Ho KIM ; Kang Hun LEE ; Sou Ouk BANG
Korean Journal of Anesthesiology 2004;47(1):69-74
BACKGROUND: Peripheral venous pressure (PVP) was known to have significant correlation with central venous pressure (CVP) in patients with normal and abnormal cardiac function. The purpose of this study is to evaluate the possibility of PVP as a substitute of CVP for volume status monitoring. METHODS: 41 hypovolemic patients with pulmonary capillary wedge pressure (PCWP) below 10 mmHg, scheduled for elective coronary artery bypass graft were included. CVP and PVP were measured from proximal port of pulmonary artery (PA) catheter and antecubital vein, respectively. Each was connected to the same monitoring system by rigid tubes of same length. Measurements were performed as follows: after PA catheter insertion; after increasing PCWP above 10 mmHg by I.V. fluid infusion; and after anesthesia induction. Hemodynamic variables were recorded at end-expiration after stabilizing for 5 10 minutes. For statistical analysis, Bland and Altman plot was created. RESULTS: The overall mean bias between CVP and PVP was 0.7 mmHg (95% confidence interval, 1 0.5). Limits of agreement of mean bias was 2.1 3.6 mmHg. 118 out of 121 PVP measurements were within the ranges of CVP +/- 3 mmHg (98%). The direction of CVP change was predicted by PVP in 68%. However, larger changes of PVP (> or = 2 mmHg) predicted the changes of CVP with increased accuracy (90%). There were only 5 cases that CVP and PVP had changed in opposite direction. CONCLUSIONS: In conclusion, PVP has a potential to be a substitutional hemodynamic parameter of CVP.
Anesthesia
;
Bias (Epidemiology)
;
Catheters
;
Central Venous Pressure*
;
Coronary Artery Bypass
;
Coronary Artery Disease*
;
Coronary Vessels*
;
Hemodynamics*
;
Humans
;
Hypovolemia*
;
Pulmonary Artery
;
Pulmonary Wedge Pressure
;
Transplants
;
Veins
;
Venous Pressure*
10.Comparison on short-term safety outcomes between off-pump and on-pump coronary artery bypass grafting by experienced surgeons: a single center study with 31 075 cases.
Zhan HU ; Xin YUAN ; Si Peng CHEN ; Yun Hu SONG ; Wei WANG ; Shui Yun WANG ; Li Qing WANG ; Wei FENG ; Sheng LIU ; Han Song SUN
Chinese Journal of Cardiology 2021;49(2):158-164
Objective: To compare the short-term outcomes between off-pump and on-pump coronary artery bypass graft (CABG) by experienced surgeons with similar surgical team in a single large-volume cardiac surgery center. Methods: A total of 31 075 patients with multivessel coronary disease who underwent isolated off-pump or on-pump CABG between January 1, 2009 and December 31, 2019 by experienced surgeons in Fuwai hospital were enrolled in this retrospective study. Patients was divided into on-pump CABG group and on-pump CABG group on an intention-to treat basis. Short term safety endpoints, including 30 days mortality, composite endpoint of major morbidity or mortality, prolonged postoperative length of stay (PLOS), and prolonged ICU length of stay (PICULOS), and distal anastomosis were compared between the two groups. Mortality was evaluated on 30 days post operation, other endpoints were collected before discharge. After 1∶1 propensity-score matching of baseline characteristics for on-pump and off-pump CABG, postoperative endpoints were compared with use of McNemar's test and further adjusted with the use of a logistic regression model. Results: After propensity-score matching, 10 243 matched pairs of patients were included in the final analysis, there were 4 605(22.5%) females and mean age was (60.7±8.6) years. The standardized differences were less than 5% for all baseline variables in matched cohort. Univariate analysis indicated lower risk of 30 days mortality (0.2% vs. 0.7%, P<0.001), major morbidity or mortality (5.7% vs. 8.8%, P<0.001), PLOS (3.2% vs. 4.9%, P<0.001), PICULOS (9.4% vs. 12.2, P<0.001), and lower number of distal anastomosis ((3.3±0.8) vs. (3.6±0.8), P<0.001) in off-pump CABG group than in on-pump CABG group. After adjustment of cofounders, multivariate analysis showed that off-pump CABG was still associated with a lower risk of 30 days mortality (OR=0.29, 95%CI: 0.09-0.87, P=0.027), composite endpoint of major morbidity or mortality (OR=0.60, 95%CI: 0.53-0.68, P<0.001), PLOS (OR=0.64, 95%CI 0.54-0.75, P<0.001), PICULOS (OR=0.76, 95%CI: 0.69-0.84, P<0.001). Conclusions: Off-pump CABG is related with superior short-term safety outcomes than on-pump CABG by experienced surgeons in our center.
Aged
;
Coronary Artery Bypass
;
Coronary Artery Bypass, Off-Pump
;
Coronary Artery Disease/surgery*
;
Female
;
Humans
;
Middle Aged
;
Postoperative Complications/epidemiology*
;
Retrospective Studies
;
Surgeons
;
Treatment Outcome