PURPOSE: To evaluate the association with corneal thickness and corneal thinnest point using Orbscan topography. METHODS: One hundred and four eyes of the 52 normal subjects who were investigated using an Orbscan topography, were devided into following two groups ; one was inferonasal group which has the thinnest point in inferonasal quadrant(23 eyes, 22.1%), and the other was inferotemporal group which has the thinnest point in inferotemporal quadrant. (79 eyes, 76%) Among them, age-matched 30 eyes were randomly selected. The corneal thickness of two groups were measured at eight meridian of each point distant 1.0, 1.5, 2.0, 2.5, 3.0mm from corneal center. The thickest point and the thinnest point of cornea in two groups were compared and analysed. RESULTS: The thickest point of cornea in two groups was located in the superior portion. The thinnest quadrant was located in the inferonasal portion for inferonasal group and in the inferotemporal portion for inferotemporal group. CONCLUSIONS: The quadrant where the thinnest quadrant existed had the thinnest corneal thickness in comparing with any other quadrant.
Cornea

Degenerations and dystrophies of the cornea may generally be considered in four categories as follows; 1. Senile changes. 2. Degenerations. 3. Dystrqphies. 4. Corneal infiltrations due to metabolic disturbances, (carbohydrate, lipid, protein). In this discussion, many degenerations and dystrophies were reviewed.
Cornea*

In 1978, a nonprogressive corneal dystrophy was seperated from other causes of congenital opacification on the basis of unique clinincal findings and characteristic electronmicroscopic findings. This disorder, termed congenital hereditary stromal dystrophy, appears to the result of disordered stromal fibrogenesis. Recently, the autors have experienced 4 members of a family with typical electronmicroscopic findings of congenital heaeditary stromal dystrophy of the cornea. In this report we describe the characteristic findings of congenital hereditary stromal dystrophy.
Cornea* ; Humans

In order to clarify the initiation and extent of the recovery of sensitivity in the grafted eyes, the corneal sensitivity was measured on 24 normal eyes and 12 grafted eyes with Cochet-Bonnet aesthesiometer. The sensitivity in the central cornea of the normal eyes was 59 +/- 4mm. The grafted eyes showed a significant difference of sensitivity in the different portion of the recipient peripheral cornea. In the corneal graft, some recovery of sensitivity was observed from the first post-operative month and reached 20 +/- 16mm after after 3-month. The sensitivity in the corneal graft was, however, still much lower than the normal eyes and also than the unsevered peripheral cornea. The sensitivity of the corneal graft showed no significant correlation with the age of graft and with the sensitivity of the recipient peripheral cornea.
Cornea ; Transplants*

62 people (124 eyes) age from 21 to 49 (35 males, 27 females) are divided into 2 groups: in the first group 18 objects (36 eyes) with conjunctivitis, in the second group 44 objects (88 eyes) without conjunctivitis. All objects have taken Shirmer test (I and II), BUT, test of Rose-bengal and fluorescein. All are applied with Sanlein (Santen Agency). And those tests are measured after 1 and 3 months. Results: The Shirmer I and II, and BUT in the group 2 is higher than in the group 1, though BUT of both groups is at under normal level. Test of Rose-bengal 1 and 2 in group 1 is higher than in group 2. The intergrity of epithelial cells is also changed. Tear secretion of both groups at normal physiological level. Sanlein has good effect, partially improves tear indicator
Bodily Secretions ; Cornea ; Computers

Chondroitin sulfate (CS) in corneal preservation medium can porolong corneal preservation time. The solutions used in the experimental chambers were made of TC-199 (GIB Co.) either by itself of by adding 1% CS (Sigma) to the TC-199. The evaliation of the viability of corneas can be made by monitoring their physiological parameter. Thus, we monitored the transendothelial electrical potential difference (p.d.) across deepithelialized rabbit corneas. We found that TC-199 containing 1% CS maintained higher p.d.'s than the same solution without CS.
Chondroitin Sulfates* ; Chondroitin* ; Cornea*

PURPOSE: To evaluate the endothelial function of cornea preserved in newly developing korean corneal storage media (CS002, CS003) by estimating the permeability of corneal endothelium and the change of corneal thickness. METHODS: The cornea were divided into six experimental groups - fresh group immediately after enucleation, 4degrees Cmoist chamber group preserved for 24 hours and 48 hours, Optisol & CS002 group for 1, 3, 5, and 7 days, and Likorol & CS003 group for 7, 10, and 14 days after enucleation, and then corneal endothelial permeability(Pac) was measured using carboxyfluorescein solution. Corneal thickness was measured using pachymeter(fine focus adjustment) of the specular microscope. RESULTS: Corneal endothelial Pac (x1 0(- 4) cm/min) was 3.64+/-0.33 in fresh group, 4.79+/-0.28 in 4degrees Cmoist chamber group for 24 hours. Each endothelial Pac of CS002 group at 5 and 7 days was 5.81+/-0.55 and 5.65+/-0.58, which were different with 4degrees Cmoist chamber preservation group for 24 hours(p<0.05) but not different with Optisol groups at same days. Each endothelial Pac of CS003 group at 7, 10, and 14 days was 4.34+/-0.34, 4.66+/-0.59, and 4.66+/-0.27, which were not different from those of Likorol. Each corneal thickness of CS002 and Optisol group at 7days was 417.80+/-19.37 mu m and 421.00+/-19.75mu m, which were resemble increment. Corneal thickness was 426.75+/-22.43mu m in CS003 group and 476.00+/- 40.08mu m in Likorol group at 7days. There was statistical difference between the two group(P<0.05), and this difference was sustained for 14days (P<0.05). CONCLUSION: There was no difference in the effect on corneal endothelial permeability between korean corneal storage media such as CS002 and CS003, and that of previous corneal storage media such as Optisol and Likorol. Corneal thickness of cornea preserved in korean corneal storage media was thinner than that of Likorol.
Cornea* ; Endothelium, Corneal ; Permeability

This paper is to review pathogenetic mechanisms in inflammatory diseases of the cornea. After demonstration of immune corneal reactions were first undertaken in the early 20th century, the considerable changes in concept of corneal inflammation were taken. It has been the focus of immune mechanism to introduce the various aspects of corneal inflammation, especially definition of inflammation, inflammatory stimulus, normal host response, and histopathalogical evolutionof simple corneal ulcer and repair of corneal tissues.
Cornea ; Corneal Ulcer ; Inflammation*

In 24 pterygium patients, the corneal curvature was measured before and after surgical removal. The norizontal curvature increased more than 0.5 D in 66.7% of cases on the 2 to 3 weeks postoperatively. The vertical curvature, however, showed no marked tendency to changes, and only 25% of cases showed more than 0.5 D increase on the 2 to 3 weeks postoperatively. As the pterygium invades the cornea extensively, the horizontal corneal curvature increased more markedly.
Cornea ; Humans ; Pterygium*

We performed eight radial line cuts in anterior radial keratotomy(RK) employing the Russian style and the American style incisions on 103 eyes from August/ 1989 to March/ 1990. To analyze the results of myopic correction according to the size of the central optical zone and the incision length in RK, we chose the central optical zone size according to the degree of myopia (4.0 mm from -1.50D to -2.75D, 3.5mm from -30D to -3.75D and 3.0mm above -4.0D) and measured the length of each of the eight radial incisions of the cornea. The results were as follows: 1. In determining the average length of each corneal incision in RK, the longest was the superior and superior-nasal incision and the shortest was the temporal and inferior-temporal incision, regardless of the central optical zone size. 2. The total length of each of the eight incisions in each eye ranged from the longest at 3.0mm of central optical zone and the shortest at 4.0mm of central optical zone Undoubtedly, total incision length affected clinical results not significantly (p>0.05). 3. Assessing the clinical effect of myopic correction according to the optical zone size, smaller diameter clear zones produce a greater flattening of the cornea than larger ones. 4. The clinical result was not significantly affected by the direction of the incision (p>0.05).
Cornea ; Keratotomy, Radial* ; Myopia