Partial capital resection (cheilectomy, partial capitectomy, excision of a lip) has gained an accepted place in treating the Legg-Calve-Perthes disease with severely malformed femoral head in which containment surgery has rarely been successful. The clinical experiences in six children aged over 10 years who complained marked limitation of hip motion with severe collapse and subluxation of femoral head are presented. Postoperative results including clinical and radiological findings are quite promising.
Child ; Containment of Biohazards ; Head ; Hip ; Humans ; Legg-Calve-Perthes Disease

To evaluate the role of MR in the examination of Legg-Calve-Perthes(LCP) disease, we retrospectively analysed the signal intensity of the osseous lesion, thickness of the articlar cartilage, change of surrounding soft tissue. Joint effusion and femoral head containment in 32 cases of LCP diseases in 27 patients. The bony lesion was limited witin the epiphysis in 19 cases(59%) and extended to the physis and metaphysis in 13 cases(41%). The epiphyseal lesion showed homogeneous(26/32) or heterogeneous(6/32) low signal intensity(ST) on T-1 weighted images(T1WI). And homogeneous (16/28) or heterogeneous(12/28)low SI on T-2 weighted images(T2WI). The metaphyseal lesion showed low SI(13/13) on T1WI, and low(9/11) or iso(3/11)SI on T2WI. Associated metaphyseal cyst showed low SI on T1WI and high SI on T2WI. An althought physeal involvement(13/32) was indistinct, the lesion showed increased SI on both T1 and T2WI. Thickening of articular cartilage(32/32), swelling f the ligamentum teres(7/32), synovial hypertrophy(7/32) and joint effsion(27/32) were demonstrated. Lateral subluxation of the femoral head on coronal image indicated incongruity of the femoral head in 25cases(78%) We conclude that MR is an useful tool for the diagnosis as well as treatment planning in LCP disease.
Cartilage ; Containment of Biohazards ; Diagnosis ; Epiphyses ; Head ; Humans ; Joints ; Legg-Calve-Perthes Disease* ; Retrospective Studies

Currently, the drug pricing and reimbursement schemes in the Korean Medical Insurance System are based on a purchasing price reimbursement system. Since the pharmaceutical pricing is not stable and is continuously increasing, a need has developed for an analysis of the reason for the increase in pharmaceutical pricing and appropriate management measures. Consequently, a policy for the optimization of pharmaceutical expenditures in the Korean National Health Insurance (KNHI) System was introduced in 2006. In this policy, conversion to positive list system, price-volume agreements, and intensification of postmanagement of drug costs were newly introduced. In Korea, there are difficulties in smooth decisionmaking between the insured and the pharmaceutical companies in the process of determining the reimbursed price. When a proper agreement on the drug price is not made, the expenses of drug could incentive rapidly. This study was focused on the process of change in the policy of drug pricing and reimbursement in KNHI system to analyze its significance and study appropriate measures for drug reimbursement decision-making. The data for this study was collected mainly from announcement data of international and domestic agencies, related groups, and experts, along with data on the current situation regarding purchase of drugs, yearly status data, and statistical data for drugs. In Korea, the positive list system for the insured decides whether or not the national insurance will provide reimburse. Thus, it affects the demand determination through a large impact on the burden on the patients themselves. Principly the price of drug determined by the patient as a direct demander. The KNHI could be a agency for patient. The KNHI should find-out the proper purchasing method. Thus, this study proposes principles for drug pricing and reimbursement by inducing price competition according to market principles in Korea's health insurance determination.
Containment of Biohazards ; Drug Costs ; Health Expenditures ; Humans ; Insurance ; Insurance, Health ; Korea ; Motivation ; National Health Programs

With the development of biological technology, many genetically engineered microorganisms (GEMs) for special purposes have been constructed and developed, but their practical applications in the field are still limited because GEMs may cause new environmental contaminations. To minimize the potential risks, the organisms released to environment need to be monitored and restricted for their distribution. In the laboratory conditions, the GEMs can be wiped off when required using some new biological technologies. The recent progress of research on the monitoring methods and active biological containment system for GEMs were reviewed in this paper.
Containment of Biohazards ; methods ; Environmental Monitoring ; methods ; Genes, Bacterial ; Genetic Engineering ; Organisms, Genetically Modified

PURPOSE: To analyze complications and their effects on prognoses of children hip fractures. MATERIALS AND METHODS: 26 childhood hip fractures (6 type I, 7 type II, 10 type III, 3 type IV) were studied for 11 years (1986-1997) . We analyzed factors possibly related to complications and their effects on prognoses, especially avascular necrosis (AVN) of the femoral head. RESULTS: Of 26 patients, there were 7 AVN (27%) , 2 nonunions (8%) , 3 coxa vara (12%) , 9 premature epiphyseal closures (35%) , and 2 infections (8%) . Of 7 patients with AVN, 3 patients had type I fracture and 4 patients had type II fracture. No AVN developed in type III and IV fractures. Of 2 patients who had type I fracture with dislocation, all patients had AVN (100%) . Four of 14 patients who had displacement of the fracture site and one in 10 patients who had non-displacement fracture developed AVN. In our study of the incidence of AVN according to surgical reduction time after injury, 3 (60%) of 5 patients who were treated by surgical reduction within 6 hours and 4 (19%) out of 21 patients who were treated by surgical reduction after 6 hours developed AVN. CONCLUSION: In childhood hip fracture, surgical reduction time after trauma (<6 hours) did not seem to be a critical factor in preventing AVN. Force of injury and level of fracture site which jeopardize the blood supply to the femoral head were important factors. Age at time of injury was also important. Containment treatment of younger children (<10 years) and surgical treatment of older children (>10 years) were found to be an effective treatment of AVN. AVN concomitant with pyogenic infection had the worst prognosis.
Child* ; Containment of Biohazards ; Coxa Vara ; Dislocations ; Head ; Hip Fractures ; Hip* ; Humans ; Incidence ; Necrosis ; Prognosis

The subluxation of the femoral head is one of important prognostic factors in LCPD and current treatment of LCPD is based on the premise that adequate containment of the vulnerable femoral head within the acetabulum during the process of repair should result in a more spherical femoral head and a more congruous joint than if treatments were not provided.We analised the arthrographic findings of 18 hips in unilateral LCPD in order to determine the changes of the femoral head and acetabulum, degree of the subluxation and containment of the femoral head in various position of hip. The results were as follows: 1. According to the result of sphericity, the femoral head was deformed mainly in coronal plane in LCPD. 2. Average medial joint space of normal hip was about 3.8mm in the AP view of hip, but it was more increased in any position of LCPD. 3. In abduction with internal rotation, average subluxation ratio was 7.5% in normal hip and 10.9% in LCPD. In abduction with external rotation, it was 8.3% in normal hip and 12.4% in LCPD. 4. In normal hip, the containment ratio was more than 1.0 in any position of hip, but the containment ratio was 1.03 in abduction with internal rotation and 0.95 in abduction with external rotation of hip in LCPD. 5. On the basis of these results, efficacy of the Scottish Rite orthosis was doubtful in most hips of LCPD.
Acetabulum ; Arthrography ; Containment of Biohazards ; Head ; Hip ; Joints ; Legg-Calve-Perthes Disease ; Orthotic Devices

Animals ; CRISPR-Cas Systems ; Containment of Biohazards ; Gene Editing ; ethics ; methods ; Humans

People living in communal settings, such as in residence halls, are vulnerable to infectious outbreaks and once it occurs, it can be difficult to prevent its spread. An outbreak of pandemic influenza (H1N1 2009) virus was confirmed in September 2009 in an international residence hall of a university in Seoul, Republic of Korea. Herein, we report an outbreak of the pandemic influenza in a university residence hall that was successfully contained by applying the recommended infection control guidance: active surveillance system, isolation of the patients, contact precaution, and education.
Containment of Biohazards ; Disease Outbreaks ; Humans ; Infection Control ; Influenza A virus ; Influenza, Human ; Pandemics ; Republic of Korea ; Viruses

On December 14, 2017, a faculty member of a university in Hunan Province reported that an anthrax vaccine strain might have recovered virulence during an undergraduate experiment and potential exposure could not be ruled out for the students involved. Upon receiving the case report, the CDC, health bureaus, and local governments at the county, prefectural, and provincial levels promptly organized experts in different fields (including epidemiologists, biosafety experts, and laboratory testing experts) for case investigation, evaluation, and response. As the investigation results showed, no virulence recovery was identified in the involved anthrax vaccine strain; and no contamination of Bacillus anthracis was detected at the involved areas. Thus, the university returned to normal functioning.
Anthrax Vaccines ; analysis ; Bacillus anthracis ; pathogenicity ; China ; Containment of Biohazards ; Humans ; Laboratories ; statistics & numerical data ; Virulence

PURPOSE: To evaluate the radiologic changes in the acetabulum after shelf acetabuloplasty in Legg-Calve-Perthes (LCP) disease. MATERIALS AND METHODS: From January 2003 to March 2006, 13 patients with unilateral LCP disease were treated by shelf acetabuloplasty. The mean follow-up period was 51 months. Pre-operative, post-operative, and annual follow-up radiographs were obtained to assess the changes in lateral subluxation ratio (LSR), acetabular head quotient (AHQ), acetabular depth index (ADI), acetabular height index (AHI), total depth index (TDI) and width of bone graft. RESULTS: The mean LSR decreased from 1.78+/-0.32 pre-operatively to 1.48+/-0.15 post-operatively, and remained 1.33+/-0.21 at last follow-up (p=0.011). The mean AHQ increased from 81.0+/-7.5% pre-operatively to 120.0+/-15.1% post-operatively, and remained 109.7+/-13.8% at final follow-up (p=0.001); the post-operative TDI that included the width of bone graft, decreased at follow-up. Furthermore, the mean ADI and AHI changed from 0.97+/-0.12, 1.13+/-0.07 pre-operatively to 1.04+/-0.02, 1.15+/-0.09 post-operatively; last follow-up results were 1.03+/-0.05 and 1.16+/-0.07, respectively. Between the 2 indices, post-operative ADI for 2 years was statistically significant (p<0.05). Also, the width of bone graft decreased from 24.4+/-3.6 mm post-operatively to 15.0+/-4.1 mm at final follow up (p<0.05). CONCLUSION: The indices LSR and AHQ confirmed that the shelf acetabuloplasty could preserve the femoral head containment. The growth of the acetabulum after shelf acetabuloplasty was stimulated by increasing the depth of acetabulum in comparison with height for postoperative 2 years. Further follow-up is needed until skeletal maturity.
Acetabulum ; Containment of Biohazards ; Follow-Up Studies ; Head ; Humans ; Legg-Calve-Perthes Disease ; Transplants