Among the 63 patients with histopathologically proven primary squamous cell anal cancer who were managed in Presbyterian Medical Center and Yonsei University Cancer from Jan. 1971 to Dec. 1991, 34 patients, who were managed with surgery alone (abdominoperineal resection) or post-operative radiotherapy and concurrent chemoradiotherapy were analyzed. With mean follow up time of 81.3 months, 30 patients (88%) were followed up from 17 to 243 months. In methods, 10 patients were treated with surgery alone. 9 patients were treated with combined surgery and postoperative radiotherapy (59~60 Gy in 28~30 fractions). 15 patients were treated with concurrent chemoradiotherapy. Chemotherapy (Mitomycin C 15 mg/squ, bolus injection day 1;5-FU, 750 mg/squ, 24hr infusion, day 1 to 5) and radiotherapy started the same day. A dose of 30 Gy was given to the tumor and to the pelvis including inguinal nodes, in 15 fractions. After 2 weeks a boost of radiotherapy (20 Gy) to the ano-perineal area and second cycle of chemotherapy completed the treatment. The overall 50year survival rate was 56.2%. concurrent chemoradiotherapy group was 70% and surgery alone group was 16.7%. According to the cox proportional harzard model, there was significant different between survival with concurrent chemoradiotherapy and surgery alone (p=0.0129), but post-operative radiotherapy was 64.8%, which was not stastically significant (p=0.1412). In concurrent chemoradiotherapy group, the anal function preservation rate was 87% and the severe complication rate (grade 3 stenosis and incontinence) was 13.3%. In conclusion, we conclude that the concurrent chemoradiotherapy may be effective treatment modality in patients with anal cancer
Anus Neoplasms* ; Chemoradiotherapy* ; Constriction, Pathologic ; Drug Therapy ; Follow-Up Studies ; Humans ; Pelvis ; Protestantism ; Radiotherapy ; Survival Rate

We describe our initial experience with the use of biodegradable (BD) stents in benign ischemic colorectal strictures with two cases. The first case is of a 40-year-old male with a history of retroperitoneal sarcoma who developed a benign stricture in the descending colon postsurgical and radiotherapy treatment. Balloon dilation was required in order to pass the delivery system. The patient experienced significant pain postdeployment and post procedure computed tomography scan demonstrated a small perforation requiring an emergency laparotomy. The second case is a 61-year-old male with a history of retroperitoneal sarcoma who also developed an ischemic stricture in the descending colon after surgical excision. Using a combined fluoroscopic and endoscopic approach 3 separate BD stents were inserted over a 17-month period improving clinical symptoms of intermittent obstruction. These symptoms reoccurred after stent disintegration and the patient was definitively managed surgically with colostomy formation. The use of BD stents, although appealing, does not provide an adequate long term result. Additionally, more flexible, smaller calibre systems are required for deployment in tortuous environments.
Adult ; Colon, Descending ; Colostomy ; Constriction, Pathologic* ; Emergencies ; Humans ; Laparotomy ; Male ; Middle Aged ; Radiotherapy ; Sarcoma ; Stents* ; Tigers*

Among 165 patients of esophagus cancer treated by either radiation alone or postoperative radiation, median survival period was 6.6 months, 16% 3 years and 8% 5 years crude survival in biphasic plotting of survival curve semilogarithmically all nonresponder died within one year regardless of treatments and in responder each 1, 2, 3 years survival rate was 80%, 70%, 60% in the group of postoperative radiation among 20 patients (54% of 37 patients) respectively and 62%, 38%, 23% each in the group of radiation alone among 61 patients (48% of 128 patients) respectively, better survival rate of postoperative radiation vs radiation alone in 3 year (p<0.01). The most common cause of death was dysphagia 55%, and majority of patients died by failure to control the disease locally 62%, 88% of stricture were associated with persistenece of cancer in esophagus. 50% of patients was found to have locoregional metastatic nodes. Preoperative diagnostic failure rate was for metastatic locoregional nodes was 54%, for grossly metastatic nodes 29.7%, for blood borne organ metastasis 13.5%, and for local extent of the disease 14%. The residual cancer at surgical margin on postitive node was not effectively killed by either 5000 to 5500 cgy conventional radiation or 5290 to 5750 cgy with 115 cgy fraction in 2 times daily; hyperfractionated radiation. However hyperfractionation schedule decreased the both acute and late complications in this study.
Appointments and Schedules ; Cause of Death ; Constriction, Pathologic ; Deglutition Disorders ; Esophageal Neoplasms* ; Esophagus* ; Humans ; Neoplasm Metastasis ; Neoplasm, Residual ; Radiotherapy* ; Survival Rate

OBJECTIVE: We wanted to evaluate the effectiveness of intraluminal irradiation with Holmium-166 (166Ho) for reducing the pseudointimal hyperplasia (PIH) in the transjugular intrahepatic portosystemic shunt (TIPS) tract in a swine model. MATERIALS AND METHODS: TIPS was performed in 12 domestic pigs, after the creation of portal hypertension by intraportal injection of a mixture of N-butyl-2-cyanoacrylate (NBCA) and lipiodol. Five pigs first underwent intraluminal irradiation (30 Gy) in the parenchymal tract with using a 166Ho solution-filled balloon catheter, and this was followed by the placement of a nitinol stent in the TIPS tract. For the seven control pigs, the balloon was filled with saline and contrast media mixture. Two weeks later, follow-up portography and histological analysis were performed. RESULTS: TIPS was successfully performed in all twelve pigs with achieving artificially induced portal hypertension. Portography performed two weeks after TIPS showed the patent tracts in the TIPS tracts that were irradiated with 166Ho (5/5, 100%), whereas either completely (5/6, 83.3%) or partially (1/6, 16.7%) occluded TIPS were seen in the seven pigs of the nonirradiated control group, except in one pig that experienced periprocedural death due to bleeding. Histological analysis showed a statistically significant difference for the maximal PIH (irradiated: 32.8%, nonirradiated: 76.0%, p < 0.001) between the two groups. CONCLUSION: Intraluminal irradiation with 30 Gy of 166Ho for TIPS significantly improved the TIPS patency in a swine model of portal hypertension during a 2-week period of follow-up.
Alloys ; Animals ; Constriction, Pathologic/*radiotherapy ; Holmium/*therapeutic use ; Hypertension, Portal/therapy ; Portasystemic Shunt, Transjugular Intrahepatic ; Radioisotopes/*therapeutic use ; Stents ; Swine

PURPOSE: To overcome the limitations of expandable metallic stent placement by using balloon dilation combined with chemotherapy or radiation therapy in the treatment of malignant esophageal strictures involving the esophagogastric junction (EGJ). MATERIALS AND METHODS: Fluoroscopically guided balloon dilation was performed in 14 patients with strictures due to squamous cell carcinoma (n=5) or adenocarcinoma (n=9). After balloon dilation all patients underwent chemotherapy or radiation therapy. RESULTS: There were no technical failures or major complications. After dilation, dysphagia improved in 13 (92%) of 14 patients, and the long-term success rate was 50%. Six of the seven patients in whom the condition recurred underwent further balloon dilation (n=4) or placement of an expandable metallic stent (n=2). Ten of the 13 who were followed up died after diffuse metastasis. Prior to their eventual death (mean survial, 20 weeks), the dysphagia experienced by seven (70%) of these ten improved, and thus they required no further treatment. CONCLUSION: Balloon dilation combined with chemotherapy or radiation therapy seems to be a safe and effective secondary therapy for patients with dysphagia due to malignant stiricture involving the EGJ.
Adenocarcinoma ; Carcinoma, Squamous Cell ; Constriction, Pathologic* ; Deglutition Disorders ; Drug Therapy* ; Esophagogastric Junction* ; Humans ; Neoplasm Metastasis ; Palliative Care* ; Radiotherapy* ; Stents

BACKGROUND AND OBJECTIVES: The traditional form of reconstruction of multiple defects after head and neck cancer ablation has been the two-combined regional flaps or that of one regional flap and skin graft. Such flaps, however, have functional and aesthetic problems such as donor site morbidity, and post-operative stenosis and fistula. MATERIALS AND METHODS: We reviewed clinical data of eleven head and neck cancer patients who have been reconstructed with bilobed flaps or gemini flaps after ablation from November 1988 to October 1998. The patients were divided into four groups. Type I flap is bilobed flap consisting of one bed and fused skin, type II flap is gemini flap consisting of one bed and separated skin, type III flap is gemini flap consisting of separated skin and bed, and type IV flap is bilobed flap or gemini flap composed of free bone graft. RESULTS: The survival rate of bilobed flaps and gemini flaps was 91%. The most common complication was fistula, followed by donor vein thrombosis and total loss of flap. CONCLUSIONS: The advantages of bilobed flaps and gemini flaps were one-stage operation, and aesthetic effect for reduced bulk of thinned radial free forearm flap, and diminished morbidity of donor site. Bilobed flaps and gemini flaps were also used for salvage operation of the patients who had been treated with concomitant chemo-radiotherapy, or combined chemo-radiotherapy, or radiotherapy alone for malignant tumors of head and neck.
Constriction, Pathologic ; Fistula ; Forearm ; Head and Neck Neoplasms* ; Head* ; Humans ; Neck ; Radiotherapy ; Skin ; Survival Rate ; Thrombosis ; Tissue Donors ; Transplants ; Veins

Curative treatment of hepatocellular carcinoma (HCC) with portal vein invasion is difficult to achieve, and the prognosis is dismal. Combining external beam radiotherapy (EBRT) with hepatic arterial infusion chemotherapy (HAIC) has shown favorable local therapeutic effects for patients with HCC exhibiting portal vein invasion. Stereotactic body radiotherapy (SBRT) is a recently developed EBRT modality that shows excellent tumor control. The combination of SBRT and HAIC for HCC with portal vein invasion has not been well-studied. We report a patient with HCC and portal vein invasion who achieved 15 months of survival with complete response status after combination SBRT and HAIC. The patient later experienced grade 3 biliary stricture and died of liver abscesses of unknown etiologies that subsequently appeared.
Carcinoma, Hepatocellular ; Constriction, Pathologic ; Drug Therapy ; Humans ; Liver Abscess ; Portal Vein ; Prognosis ; Radiosurgery ; Radiotherapy ; Therapeutic Uses ; Venous Thrombosis

BACKGROUND: Restenosis after percutaneous coronary intervention (PCI) still remains a matter to be solved. We examined the inhibitory effects of local delivery of 99mTc-HMPAO (hexamethylprophylene amine oxime), a radioisotope, on neointimal hyperplasia after coronary stenting through an animal experiment, and observed its safety and efficacy for the patients with coronary stent restenosis. METHODS: Stent overdilation injuries were performed in coronary arteries of 10 pigs. After stent overdilation injury, local radioisotope delivery using a 99mTc-HMPAO were performed in one coronary artery (Group I) and control therapy in another coronary artery in each pig (Group II). Follow-up coronary angiogram (CAG) and histopathologic assessment were performed at 4 weeks after stenting. Eleven patients (10 males, 62.4+/-5.7 years of age) underwent local administration of 30 mCi/ 2 mL of 99mTc-HMPAO shortly after PCI via Dispatch CatheterTM, and whole body bone scan and thallium-SPECT afterwards. Major adverse cardiac events (MACE) were assessed during one-year clinical follow-up. RESULTS: On histopathologic analysis, neointimal area was 1.2+/-0.6 mm2 in Group I and 2.7+/-0.4 mm2 in Group II (p=0.002), and histopathologic area stenosis was 27.1+/-6.3% in Group I, 53.4+/-5.2% in Group II (p=0.001). In clinical study, eleven patients with coronary in-stent restenosis were enrolled. There was no in-hospital MACE. On quantitative coronary angiographic analysis minimal luminal diameter and diameter stenosis increased from 0.4+/-0.3 mm and 84.2+/-9.5% to 2.9+/-0.2 mm and 16.3+/-11.0% after PCI, respectively. Follow-up CAG was performed in 9 cases (81.8%) and restenosis occurred in 2 cases (22.2%). On follow-up CAG minimal luminal diameter was 2.0+/-0.8 mm, diameter stenosis rate 27.7+/-2.9 %, lumen loss 0.7+/-0.7 mm and loss index 0.2+/-0.3. During one-year clinical follow-up there were no cases of death and acute MI, but two cases of target vessel revascularization (18.2%). CONCLUSION: Local delivery of 99mTc-HMPAO, one of the novel radiotherapies, can be used safely and effectively for coronary stent restenosis.
Animal Experimentation ; Brachytherapy* ; Constriction, Pathologic ; Coronary Artery Disease ; Coronary Vessels ; Follow-Up Studies ; Humans ; Hyperplasia ; Male ; Percutaneous Coronary Intervention ; Phenobarbital ; Radioisotopes ; Radiotherapy ; Stents* ; Swine ; Technetium Tc 99m Exametazime*

331 patients of stage IIb uterine cervix cancer treated by radiation alone at Kosin Medical Center between June 1980 and Dec. 1985 were analysed to determine parameters of radiotherapy associated to disease states. Survival rate was highest among the reported (82.8% for crude and 82.4% for disease free survival). Pelvic control rate in 6 weeks after the end of radiotherapy was 93.6% in the patients treated with ICR following total pelvic radiation and 71.6% with small field additional external irradiation. 5 year survival rate in those who achieved pelvic control was 98. 9% and 12.9% in those who had pelvic failure and/or metastasis after radiation. The survival rate figured maximal 88.5% with dosage of 7500~8500 cgy to point A with acceptable incidence of complications (4.9%) but without increasing survival above it and minimal 74.1% with dosage of less than 6500 cgy. The treatment failure was counted 18.7% (62 of 331 patients): Local failure 72. 6% ( 45 of 62 patients), locoregional failure 3.2% (2 of 62 patients) and distant failure 24% (15 of 62 patients). Late complications were found In 50 patients (15.1%) and 42% of them was rectal bleeding and stenosis. The dose of 8500 cgy to point A was found to be critical for complication and 70% of complications occurred above it and was more serious one such as fistula. Rectal complications were developed above rectal dose 6500 cgy and bladder complication above bladder dose 7500 cgy. Major cause of death was cachexia due to locoregional failure (73.7% of death), next was due to metastasis to lung, liver and bone, and only 3 patients died of complication of intestinal perforations and obstruction. In conclusion higher external radiation dose for a bulky uterine cervix and barrel shaped uterus was essential for local control.
Cachexia ; Cause of Death ; Cervix Uteri* ; Constriction, Pathologic ; Female ; Fistula ; Hemorrhage ; Humans ; Incidence ; Intestinal Perforation ; Liver ; Lung ; Neoplasm Metastasis ; Radiotherapy* ; Survival Rate ; Treatment Failure ; Urinary Bladder ; Uterus

Tracheal stenosis is a difficult disease entity to manage. Laser ablation is one effective treatment for treacheal stenosis and can be utilized if tracheal reconstructive surgery is impossible. Potassium titanyl phosphate laser, transmitted via flexible quartz fiber, can be precisely manipulated through flexible bronchoscope under local anesthesia. We treated 7 patients with tracheal and broncheal lesion under local anesthesia with KTP laser from January 1995 to July 1996. The patients included three males and four females. The age of patients ranged from 22 to 66 years with a mean of 43.7 years. The etiology of tracheal stenosis in patients was stenosis after tracheostomy(3 cases), prolong inturbation in cases of sepsis(1 cases), and the recurrence of lung cancer within endobronchial lesion(2 cases). In the cases of tracheal stenosis treated with laser ablation, there were 2 cases of recurrence of stenosis at the anastomosis site after the operation, 3 cases of stenosis at tracheostomy site, and 2 cases of local recurrence of lung cancer. The site of the tracheal stenosis was the balloon site of the tracheostomy tube(3-4cm inferior to the tracheostomy site, 2-3cm superior to the carina) and the anastomosis site that were narrowed to less than 5mm(4 cases). For the stenosis lesion in the endobronchial area, there were 2 patients with a lesion at the anterior wall, 1 patient with a lesion at the posterior wall, 2 patients with circumferential stenosis. Laser ablation time was 25.4+/-5.9min and used energy was 1768+/-365J. We have used KTP laser via flexible bronchoscope without major complications. Adjuvant radiation therapy may prevent fibroblast proliferation which leads to restenosis. In three patients of restenosis after laser ablation, adjuvant irradiation started within 4 hours after laser ablation, and the radiation doses were 1500cGy given in five fraction. In patients with adjuvant radiation therapy, stenosis has not recurred.
Anesthesia, Local ; Bronchoscopes ; Constriction, Pathologic ; Female ; Fibroblasts ; Humans ; Laser Therapy ; Lasers, Solid-State ; Lung Neoplasms ; Male ; Potassium* ; Quartz ; Radiotherapy, Adjuvant ; Recurrence ; Tracheal Stenosis* ; Tracheostomy