2.Unraveling the Genetic Basis of Asthma and Allergic Diseases.
Jian Feng MENG ; Lanny J ROSENWASSER
Allergy, Asthma & Immunology Research 2010;2(4):215-227
Asthma and allergic diseases are believed to be complex genetic diseases which may result from the interaction of multiple genetic factors and environmental stimuli. In past decades, great efforts have been exerted in unraveling their genetic basis. The strategies in discovering genes and genetic variants, confirming their importance in pathogenesis of asthma and allergic diseases, as well as their strengths and limitations are summarized comprehensively and concisely. The current consensus about the genetic basis of asthma and allergic diseases is briefly described as well.
Asthma
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Consensus
4.Meeting Highlights: The First Korean Breast Cancer Treatment Consensus Conference.
Airi HAN ; Kyoung Eun LEE ; Hae Kyung LEE ; Yeon Hee PARK ; Jeryoung KIM ; Sung Won KIM ; Kyung Hae JUNG ; Byung Ho SON
Journal of Breast Cancer 2014;17(4):308-313
The first Korean Breast Cancer Treatment Consensus Conference Expert Panel reviewed and endorsed new evidence on aspects of local and regional therapies and diagnostic procedures that support the conservative application of results from recent clinical trials. This conference clarified the barriers that limit the application of recent clinical trial results, such as questions about level of evidence, differences between the setting of clinical trials and that of daily clinical practice, and medical necessities and environment. Detailed decisions recommended for the treatment and diagnosis, according to the from the consensus conference, are recorded including details of the votes. These recommendations differed in the degree of support for clinical consideration of disease extent and host factors, medical necessities, and environment.
Breast Neoplasms*
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Consensus*
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Diagnosis
5.Assessment of Mural Invasion Depth of Gastric Carcinoma with High-Resolution Compound Sonographic Imaging in Vitro.
Seong Hoon PARK ; Eun A KIM ; Kwon Ha YOON ; Ki Jung YUN ; Jeong Ho KIM ; Jong Jin WON
Journal of the Korean Radiological Society 2002;47(5):491-497
PURPOSE: To evaluate whether the accuracy of invasion depth assessment in gastric carcinoma in vitro can be improved with high-resolution spatial compound sonographic imaging. MATERIALS AND METHODS: In sixteen fresh gastric specimens obtained from patients with preoperatively biopsyproven gastric carcinoma, normal and lesional areas were scanned using conventional and compound imaging technique with a 15-MHz linear transducer. Two radiologists independently compared the sharpness and the contrast of images obtained with two different modes and determined the layers invaded by cancer with consensus. The invasion depths by images were compared with histopathologic results. RESULTS: The sharpness and the contrast in normal and lesional areas were significantly higher in compound imaging (p<0.01) than those in conventional imaging and interobserver agreement was over moderate, with kvalue of 0.41 to 0.86. But the accuracy in invasion depth assessment was 68.8% (11/16) on conventional imaging and 75% (12/16) on compound imaging and not different significantly between two modes (p>0.05). CONCLUSION: High-resolution spatial compound sonographic imaging has improved image quality, compared with conventional imaging, but the accuracy of invasion depth assessment in gastric carcinoma was not significantly different.
Consensus
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Humans
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Transducers
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Ultrasonography*
7.In Vitro Imaging of MRI and Ultrasound for Gastric Carcinoma.
Journal of the Korean Society of Magnetic Resonance in Medicine 2008;12(2):178-187
PURPOSE: To evaluate and compare the diagnostic accuracy of MRI and ultrasound(US) for estimation of invasion depth of gastric carcinoma by correlation with histopathologic findings in vitro and to find out the best MR pulse sequence for detection and accurate delineation of tumor. MATERIALS AND METHODS: Resected specimen of total or subtotal gastrectomy from 53 patients with gastric carcinoma were done of imaging studies of MRI and US. And US was examined by using high frequency linear transducer for tumor invasion depth by a radiologist. In each case, both imaging findings of MRI and US were evaluated independently for tumor detection and invasion depth by consensus of two radiologists and were compared the diagnostic accuracy between two imaging modalities according to the histopathologic findings. MR imaging with five MR pulse sequences, spin echo T1 and in- and out-ofphase gradient echo T1 weighted images, FSE and SSFSE T2 weighted images, were performed. Five MR pulse sequences were evaluated and compared on the point of detection and accurate distinction of tumor from surrounding normal tissue. RESULTS: In EGC, diagnostic accuracy of US(77%) was superior than that of MRI(59%) but no statistically significant difference was noted between two imaging modalities(p=0.096). In AGC, both imaging modalities of MRIand US showed relatively high diagnostic accuracy as 97% and 84% respectively. Diagnostic accuracy of MRI was statistically better than that of US at the significant level(p<0.001). The best MR pulse sequence among five in each specimen was FSE T2WI(75.5%, 40/53) in both EGC and AGC. In AGC, FSE T2WI showed excellent imaging quality by showing very high ratio (93.5%, 29/31) of accurate delineation of tumor. CONCLUSION: MRI and US show relatively high diagnostic accuracy in the evaluation of tumor invasion depth of resected specimen in AGC. The most excellent pulse sequence of MRI for the evaluation of tumor invasion depth is FSE T2WI on the point of detection and accurate delineation of tumor in both EGC and AGC.
Consensus
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Gastrectomy
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Humans
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Transducers
8.Current Understanding of Mycobacterium abscessus Infection.
Go Eun CHOI ; Youngsuk JO ; Sung Jae SHIN
Journal of Bacteriology and Virology 2012;42(1):17-28
Mycobacterium abscessus belongs to a group of rapidly growing mycobacteria (RGM) that cause a broad spectrum of infections in humans. In addition, the association of M. abscessus with the cause of community- and hospital-acquired infections has been recently reported. In fact, M. abscessus is known to be the most drug-resistant mycobacterium and naturally resistant to first-line anti-tuberculous drugs, resulting in the limited therapeutic options and a high failure rate of treatment response. Three closely related species; M. abscessus (sensu stricto), M. bolletii, and M. massiliense are currently identified however, consensus on the naming of M. abscessus-related species has not been made to date. We herein discuss the advanced understanding of the virulence potentials and pathophysiological features of M. abscessus to establish novel therapeutic strategies for M. abscessus infection.
Consensus
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Humans
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Mycobacterium
9.The Diagnosis and Management of Hyperthyroidism Consensus - Report of the Korean Thyroid Association.
Ka Hee YI ; Jae Hoon MOON ; In Ju KIM ; Hee Seung BOM ; Jaetae LEE ; Woong Youn CHUNG ; Jae Hoon CHUNG ; Young Kee SHONG
Journal of Korean Thyroid Association 2013;6(1):1-11
No abstract available.
Consensus
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Hyperthyroidism
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Thyroid Gland
10.Global Consensus Conference: Final Recommendations (AJIC 1999;27:503-13, Canadian Journal of Infection Control and British Journal of Infection Control).
Jae Sim JEONG ; Jeong Hwa CHOI
Korean Journal of Nosocomial Infection Control 2000;5(1):41-50
No Abstract available.
Consensus*
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Infection Control*