1.Design of performance appraisal and incentive compensation scheme for interventional operation platform
Hao LIANG ; Wei JIANG ; Xuanfeng LIU ; Ju HUAN ; Wei LI ; Congxin ZHANG
Chinese Journal of Hospital Administration 2017;33(9):675-678
This paper introduced the design and application of the performance appraisal scheme for the interventional operation platform.The comparison of interventional operations before and after the means of performance management in place, presented the effective role of performance management in interventional operation platform, and analyzed the motivation effect of performance management on the enthusiasm of interventional operators.The authors recommend performance appraisal and incentive compensation mechanism to motivate the clinical use of the platform, and greater application of such a common platform, for perfection of surgery performance management.
2.Influence of Wenxin particle on cardiac electrophysiology in depressed rats after myocardial infarction
Jinjun LIANG ; Shaobo SHI ; Jingjing SHEN ; Fang WANG ; Yingying SHEN ; Xiaoran YUAN ; Chuan QU ; He HUANG ; Bo YANG ; Congxin HUANG
Chinese Journal of cardiovascular Rehabilitation Medicine 2012;21(6):649-655
Objective: To investigate influence of Wenxin particle on cardiac electrophysiology in rats complicated with depression after myocardial infarction (MI). Methods: A total of 50 SD rats were randomly and equally divided into normal group, MI group, depression group, MI complicated with depression group (model group) and Wenxin particle group (Wenxin particle were given to model rats by gavage, 2 g/d, 28d). Model(MI complicated with depression)rats were made by acute ligation of left coronary artery and supply chronic unpredictable mild stress in order. The influences of Wenxin particle on cardiac electrophysiological indexes, such as monophasic action potential (MAP90), left ventricular effective refractory period (ERP) and ventricular fibrillation threshold (VFT) were evaluated in Wenxin particle group. Results: (1) Compared with normal group, there were significant decrease in behavior scores (P<0.05) in model group, after four-week treatment with Wenxin particle, their behavior scores significantly increased (P<0.01); (2) Compared with normal group, there were significant increase in MAPD90 and ERP, and significant decrease in VFT in model group (P<0.05); compared with model group, there were significant decrease in MAPD90 [(89.33±7.12) ms vs. (72.29±8.37) ms] and ERP [(84.00±6.57) ms vs. (68.00±7.43) ms], and significant increase in VFT [(7±3.11)V vs. (29±5.60)V] in Wenxin particle group, P<0.05. Conclusion: Wenxin particle can improve cardiac electrical remodeling in rats complicated with depression after myocardial infarction, including decrease monophasic action potential duration and effective refractory period, and raise ventricular fibrillation threshold.
3.Role of PI3K in systolic dysfunction of hiPSC-CMs induced by sunitinib
Congxin LI ; Guoqiang LIU ; Yang LIU ; Zhihan ZHANG ; Wei YAN ; Chunhui LIANG
China Pharmacy 2023;34(2):139-143
OBJECTIVE To study the role of phosphatidylinositol-3-kinase (PI3K) on sunitinib-induced myocardial systolic dysfunction. METHODS Using human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMS) as objects, the contractile force of cardiomyocytes was measured by CardioExcyte 96 system, and IC50 of sunitinib was calculated after hiPSC- CMS were treated with sunitinib at different concentrations [0 (control), 0.5, 1, 3, 5, 10 μmol/L] for 24 hours. The effects of sunitinib (3.14 μmol/L) on the contractile frequency of cardiomyocytes, calcium transient amplitude and calcium transient recovery time course, mRNA expression of myocardial injury markers atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP) and β-myosin heavy chain (β-MHC) were detected. PI3K activator 3,4,5-triphosphate phos-phatidylinositol (PIP3, 1 μmol/L) and sunitinib were used to intervene in hiPSC-CMs jointly, so as to investigate the role of PI3K in the myocardial systolic dysfunction induced by sunitinib. RESULTS Sunitinib inhibited the contractile force of hiPSC-CMs in a concentration-dependent manner. IC50 of sunitinib was 3.14 μmol/L. After intervention with 3.14 μmol/L sunitinib, the contractile frequency of hiPSC-CMs and calcium transient amplitude were decreased significantly (P<0.05 or P<0.01); the duration of calcium transient recovery was prolonged significantly (P<0.05), and mRNA expressions of ANP, BNP and β-MHC were significantly increased (P<0.01). After PI3K was activated with PIP3, the contractile force of hiPSC-CMs was increased significantly (P<0.01). CONCLUSIONS Activating PI3K activity is a potential molecular mechanism to improve myocardial toxicity induced by sunitinib.
4.Pharmacology and Clinical Evaluation of Ensartinib Hydrochloride Capsule.
Yang WANG ; Xiaobin YUAN ; Jiayan XIONG ; Zhidong HAO ; Xingzhe PENG ; Wanlin CHEN ; Lingling CUI ; Hua LI ; Xiulan WANG ; Xiangbo HE ; Min YANG ; Congxin LIANG ; Yongbin MA ; Lieming DING ; Li MAO
Chinese Journal of Lung Cancer 2020;23(8):719-729
Lung cancer is one of the most common malignancies with the highest incidence rate and mortality rate worldwide, and non-small cell lung cancer (NSCLC) accounts for about 85%. Only 5% NSCLC patients are anaplastic lymphoma kinase (ALK) rearrangement positive NSCLC, but the prognosis of these patients is poor, and treatment is urgent. Ensartinib (X-396), a next-generation ALK tyrosine kinase inhibitor (ALK-TKI), has shown greater potency on inhibiting ALK activity and controlling brain metastases than crizotinib, which is indicated for the treatment of crizotinib-resistant, ALK-positive NSCLC patients. Several phase I to III clinical trials included both healthy volunteers and NSCLC patients have been conducted both in China and abroad. In this review, we briefly summarized the results of these trials, and preliminary efficacy, safety, pharmacology and pharmacokinetics/pharmacodynamics of ensartinib were discussed.