1.Short-term efficacy and factors of specific immunotherapy on patients with allergic rhinitis.
Congli GENG ; Xiaopei YUAN ; Zhimin XING ; Lisheng YU ; Min WANG ; Yuqiang LIN ; Yan LIU ; Gai ZHANG
Journal of Clinical Otorhinolaryngology Head and Neck Surgery 2015;29(21):1857-1863
OBJECTIVE:
To evaluate the short-term efficacy and investigate the factors of specific immunotherapy (SIT) efficacy of allergic rhinitis.
METHOD:
Fifty-seven patients with allergic rhinitis to dermatophagoides pteronysinus were included to receive SIT. Pair t-test was used to compare the symptom scores, visual analogue scores (VAS) and medication scores in patients before SIT and into maintain treatment statement to evaluate the clinical efficacy. T-test and Spearman correlation analysis were used to analyze the correlation between gender, age,reaction condition of skin prick test (SPT) and serum sIgE and the efficacy of SIT.
RESULT:
SIT was able to significantly reduce the symptom scores, VAS and medication scores. But the correlation between gender, age, SPT, and sIgE and theefficacy of SIT were not significant.
CONCLUSION
SIT is effective in the short-term treatment of AR. Further research is needed to investigate the factors that impact the efficacy of SIT.
Animals
;
Humans
;
Immunoglobulin E
;
blood
;
Immunotherapy
;
Pyroglyphidae
;
Rhinitis, Allergic
;
therapy
;
Skin Tests
2. Impact of blood eosinophils on clinical effect of endoscopic sinus surgery for chronic rhinosinusitis with nasal polyps
Shichang LI ; Zhimin XING ; Yang YANG ; Yan LIU ; Congli GENG ; Min WANG ; Xiaopei YUAN
Chinese Journal of Otorhinolaryngology Head and Neck Surgery 2018;53(9):680-683
Objective:
To investigate the effect of blood eosinophils on clinical effect of endoscopic sinus surgery for chronic rhinosinusitis with nasal polyps (CRSwNP).
Methods:
From March 2011 to March 2016, 72 cases with CRSwNP were treated by endoscopic sinus surgery in Department of Otorhinolaryngology Head and Neck Surgery, Peking University People′s Hospital. The clinical records were retrospectively reviewed, and the cases were divided into eosinophilia elevated and non-elevated group according to blood eosinophils, and nasal polyps were evaluated for histopathology eosinophil count. Statistical analysis was performed to compare two groups′ pre- and post-operative symptoms of VAS score, sinus computed tomography (CT) scans scores according to the Lund-Mackay system and the outcome of surgery. Both groups′ factors that might have affected their outcome were analyzed by
3. The role of type 2 innate lymphoid cells in the pathogenesis of eosinophilic chronic rhinosinusitis with nasal polyps
Congli GENG ; Zhimin XING ; Lisheng YU ; Min WANG ; Xiaopei YUAN ; Yan LIU ; Gai ZHANG ; Zijing WANG
Chinese Journal of Otorhinolaryngology Head and Neck Surgery 2018;53(5):369-374
Objective:
To investigate the type 2 innate lymphoid cells (ILC2s) in eosinophilic nasal polyps, non-eosinophilic nasal polyps and controls, and to compare the characteristics of ILC2s indifferent types of nasal polyp.
Methods:
Flow cytometric analysis was used to quantify the ILC2s and Th2 cells in tissues from 19 patients with chronic rhinosinusitis with nasal polyp (CRSwNP) and 6 controls. The patients were classified into two groups as eosinophilic chronic rhinosinusitis with nasal polyps (ECRSwNP) and non-eosinophilic chronic rhinosinusitis with nasal polyps (non-ECRSwNP) based on eosinophil counts under hematoxylin-eosin staining. ILC2 and Th2 cell frenquencies, measured as a percentage of CD45+ cells, were compared among ECRSwNP group (