OBJECTIVE:To explore the general pattern and the characteristics of the adverse drug reactions(ADR)induced by ?-lactamase inhibitor.METHODS:155 ADR cases induced by ?-lactamase inhibitor reported in 141 articles in the domestic periodicals between Jan.1996 and Jan.2008 retrieved from CHKD full-text data base were analyzed respectively.RESULTS:Among the total 155 ADR cases,81.94%(127 cases)were induced by sulbactam-contained ?-lactamase inhibitor.Systemic lesion was the most common manifestation of ADR,accounting for 42.58%(66 cases).The most serious manifestation of ADR was allergic shock,and death occurred in 9 cases.CONCLUSION:It is advisable to promote rational use of ?-lactamase inhibitor and strengthen ADR monitoring so as to reduce or avoid the occurrence of ADR.

1.CON-CLUSION:Safe,effective and cheap antiinfectives assume a predominant place in our hospital.