Objective: To investigate the prevalence of metabolic diseases among residents in Moyu County, Hotan Prefecture, Xinjiang Uygur Autonomous Region, so as to provide the evidence for developing the control strategy for metabolic diseases. Methods: The demographic features, laboratory examinations and B-mode ultrasonographic examinations of the liver and gall bladder were collected from residents at ages of 18 years and older in Moyu County through the hospital-based medical records system. The prevalence of metabolic diseases was estimated, including obesity, hypertension, diabetes, dyslipidemia and fatty liver, and the factors affecting the development of metabolic diseases were identified using a multinomial logistic regression model. Results: Totally 281 803 residents were included in the study, including 129 549 men ( 49.97% ) and 152 254 women ( 54.03% ) and with a median age of 37.00 years ( interquartile range, 22.00 years ). The overall prevalence of metabolic diseases was 47.66%, and the prevalence rates of obesity, hypertension, dyslipidemia, fatty liver and diabetes were 25.72%, 24.77%, 12.30%, 12.05% and 5.49%, respectively, which appeared a tendency towards a rise with age ( χ2trend = 11 243.73, 14 086.41, 2 109.70, 6 631.22, and 2 011.15, all P<0.001 ). There were 73 811 residents suffering from one metabolic disease (26.19%), and 60 495 residents with two and more metabolic diseases ( 21.47% ). Multinomial logistic regression analysis showed that gender ( OR=0.870; 0.796 ), age ( OR: 1.703-8.701; 2.952-18.846 ), marital status ( OR: 1.397-1.845; 1.460-2.377 ) educational level ( OR: 0.891-0.937; 0.920-0.924 ), occupation ( OR: 1.177-1.270; 1.114-2.099), family history ( OR=1.136; 1.390), drinking frequency ( OR: 2.038; 1.395-2.574 ) and central obesity ( OR=3.448; 14.352 ) were factors affecting the development of one or more metabolic diseases. Conclusion The prevalence of metabolic diseases is high among residents in Moyu County. Men, the elderly, a low education level and unhealthy lifestyles may increase the risk of metabolic diseases.

Summarize the professor Hu Jingqing's experience in treating pathogenesis of intermingled phlegm and blood stasis by using purgative method.Intermingled phlegm and blood stasis is one of the most important pathogenesis of many difficult diseases in the contemporary era.From the perspective of TCM theory,the purgative method can dissipate phlegm,eliminate blood stasis and resolve masses,which is a suitable method for the treatment in pathogenesis of intermingled phlegm and blood stasis.In clinical practice,the professor Hu Jingqing emphasizes the specific classification of pathogenesis of phlegm and blood stasis in diagnosis,using the purgative methods according to different classifications of"excess heat"and"deficiency cold".And make flexible selections of various purgative drugs in prescription.Last but not least,it is suggested that the purgative method also should not be used as the only treating method.

Objective:To study the effect of continuous subcutaneous insulin infusion (CSII) in the long-term treatment of type 1 diabetes mellitus (T1DM) children, to analyze the factors influencing the efficacy, and to provide theoretical guidance for the application of CSII in long-term therapy and follow-up management.Method:A total of 60 T1DM children who were under 18 years old, lived in Qingdao for a long time, had CSII for more than 6 months, and visited the Outpatient Department of Endocrinology of Qingdao Women and Children′s Hospital for a long term from January 2019 to June 2019 were followed up with questionnaires to understand their general condition and treatment-related data.Result:After the CSII therapy, the hemoglobin A1c (HbA1c) of T1DM children significantly decreased from (9.58±2.08)% to (7.12±1.11)% ( t=7.315, P<0.05), the daily insulin dosage per unit weight significantly declined from 0.91(0.86, 0.94) IU to 0.80 (0.66, 0.88) IU ( Z=-5.514, P<0.05), and the frequency of both hypoglycemia and ketoacidosis was significantly reduced.Diet control, daily exercise time, the visit frequency and the self-monitoring frequency of blood glucose affected the curative effect of CSII therapy (all P<0.05). Conclusion:CSII therapy can effectively control the blood glucose of children with T1DM in Qingdao area, significantly lower HbA1c, and reduce the insulin dosage and the incidence of hypoglycemia and ketoacidosis.Good diet control, regular exercise, regular follow-up and a high frequency of blood glucose monitoring are associated with better glycemic control.

Purpose: The incidence rate of breast cancer (BC) has increased annually. Downstream neighbor of son (DONSON) critically affects cell cycle progression and maintains stable genomic properties; however, its relevant effects on BC growth and progression require indepth investigation. Methods: DONSON upregulation was validated in public databases. DONSON expression in matched BC and adjacent tissues and cell lines (MDA-MB-231, BT-549, and HS-578T) was determined using quantitative reverse transcription polymerase chain reaction. In vitro apoptosis, invasion, migration, and proliferation tests were performed to ascertain the functions of DONSON in BC cell lines. Then, using western blot analysis, the levels of DONSON downstream proteins were determined. Results: Compared to the control, DONSON was expressed at higher levels in BC tissues and cell lines. DONSON knockdown facilitated apoptosis and limited proliferation, migration, invasion, and S/G2 transition of BC cells In vitro. Furthermore, DONSON overexpression promoted BC cell proliferation and inhibited apoptosis In vitro. Moreover, DONSON knockdown reduced cyclin A1 and cyclin-dependent kinase 2 levels. Moreover, DONSON knockdown limited the progression of epithelial-mesenchymal transition. Conclusion DONSON critically affects BC growth and serves as a possible target and marker for the efficacy of subsequent therapies.