Objective To explore the application of WeChat video visitation model in children patients without accompanying in the neonatal intensive care unit (NICU), and seek methods to reduce the anxiety of parentsthat whose children have nocompany. Methods Totally 100 parents of children that admitted in the NICU of our hospital from April 2016 to December 2015 were selected and divided into the experimental group ( WeChat video group) and the control group ( limited access group) with 50 cases in each group according to the random number table method. The control group adopted limited visitation, and the experimental group adopted WeChat video visitation model based on the limited visitation. Self-rating anxiety scale ( SAS) and self satisfaction questionnaire were used to collect data before the hospitalization and after discharge for statistical analysis. Parents′anxiety status and satisfaction with nursing work in two groups were compared. Results There was no significant difference between two groups when children were admitted to hospital ( t=1.72,P>0.05);the anxiety scores of parents in the experimental group at first visit and after discharge were obviously reduced, in the experimental group, and they were (51.35±7.38) and (23.55±3.43); while in the control group, they were (59.68±842), (26.36±3.97)(t=-2.86,2.22;P<0.05); in the experimental group, parents′satisfaction rate was 100%, and was higher than that in the control group ( 88%) ( t=6. 383,P<0.05).Conclusions WeChat video visitation can effectively relieve the anxiety of parents that whose children have no company, so it is conducive to the rehabilitation of children. It can resolve many of the potential conflicts and disputes and improve parents′s atisfaction. Parents′passive visitation change to the initiative model and the visiting management cost is reduced, and it provides a new and effective method for the management of children without company.