Objective To describe the current status of social support of ovarian cancer patients received the chemotherapy,and to analysis how the social support affects the patients. Methods A descriptive study method was used. A total of 61 ovarian cancer patients received the chemotherapy were investigated with questionnaires on their social support, so as to learn the current status of patients' social support and analyze the effect of general information on social support. Results Social support of ovarian cancer patients received the chemotherapy was in a high level(74.63±6.66) , the support from home(26.67±2.29) was better that from others. Age (P<0.05), cultural degree (P<0.05) and medical expenses (P<0.05) of chemotherapy were of a statistical significance to the influence of social support of the ovarian cancer patients. Conclusions Nurses should pay attention to the effect of the social support system to improve the life quality and carry out health education to family members on importance of support on patients from home. At the same time, nurses should show enthusiastic about patients and mobilize social support system to promote the confidence of ovarian cancer patients on chemotherapy and promote their rehabilitation.

Lipopolysaccharides (LPS) are major outer membrane components of Gram-negative bacteria. Unlike most Gram-negative bacteria, Acinetobacter baumannii can still survive and acquire polymyxin resistance after complete loss of LPS. Previous studies of LPS-deficient Acinetobacter baumannii mostly focused on LPS-deficient strains induced by polymyxin, whose background was complex and unstable. To investigate LPS loss-mediated polymyxin resistant-Acinetobacter baumannii, this study constructed a stable and clear background LPS-deficient strain by knocking out lpxC gene in Acinetobacter baumannii ATCC 19606 with CIRSPR/Cas9, and then studied the phenotypic changes of the lpxC-deficient strain including morphology, growth rate, antibiotic susceptibility, virulence, membrane permeability, and membrane potential. Animal experiments were approved by the Animal Care and Welfare Committee Institute of Medicinal Biotechnology, CAMS and PUMC (approval number: IMB-20240119D₉). The results indicated that the lpxC gene of Acinetobacter baumannii ATCC 19606 was successfully knocked out. After losing the lpxC, the strain underwent the morphological change from rod-shaped to spherical. Furthermore, it leads to reduced growth rate, enhanced membrane permeability, decreased membrane potential, lower virulence, and increased antibiotic susceptibility to β-lactams, quinolones, aminoglycosides, macrolides, glycopeptides. The lpxC deletion results in significant changes in membrane homeostasis and adaptability of Acinetobacter baumannii. Understanding the phenotypic changes of colistin-resistant Acinetobacter baumannii mediated by LPS loss is useful for exploring the resistance mechanism of Acinetobacter baumannii and developing new therapeutic strategies.