Based on archival materials, the Xiangya's anti-epidemic history in a century from its establishment to 2020 is divided into 4 stages. The first stage (1906-1926), Edward Hicks Hume and YAN Fuqing, the founders of Xiangya, prevented and controlled smallpox and plague. The second stage (1929-1953), during the resumption of Xiangya, students prevented and controlled cholera, plague, dysentery, typhus, and other infectious diseases. In the third stage (1953-1999), in a peacetime, Xiangya actively fought against schistosomiasis, hydatidosis, malaria, leprosy, tuberculosis and other epidemics. The fourth stage (2000-2020), the era of Central South University. Medical staff in Xiangya fight SARS, influenza A (HN) flu, Ebola hemorrhagic fever, coronavirus disease 2019, etc. Over the past hundred years, Xiangya people joined together to spread benevolence and love, apply medical knowledge and skills, combat the epidemic and rescue people in difficulties, which made a great contribution to the motherland and the people.
Betacoronavirus ; China ; Communicable Disease Control ; history ; Communicable Diseases ; history ; Coronavirus Infections ; Epidemics ; history ; History, 20th Century ; History, 21st Century ; Humans ; Incidence ; Pandemics ; Pneumonia, Viral

This article is based on conceptual and methodological understanding of hygienic modernity in the nineteenthcentury Western countries: one is the concept of modern hygiene in the context of modern state and the other is methodological relation of modern hygiene to scientific theory of germ. While modern state calls for the institutionalization of medical police as an administrative tool for consolidating the governmentality what Michel Foucault calls, scientific 'invention' of germ may be considered as 'logical, philosophical and historiographical.' Furthermore, the Meiji medicine men preferred Koch's to Pasteur's laboratory framework, not because the former was scientific than the latter but because Koch's programs were more compatible with imperial needs. The objective of this paper is to investigate four ways in which hygienic modernity had been established in Meiji Japan; (i) how Meiji imperialists perceived and managed to control Japanese hygienic condition, (ii) how Meijileading doctors learned about the German modern system of hygiene to consolidate Meiji empire; (iii) how modern germ theory functioned as the formation of imperial bodies in Meiji period; and (iv) how modern military hygiene contributed to Japanese defeat of Russia. Although I try to contend that modern hygiene was adopted as one of the most significant strategies for intensifying and extending the Meiji empire, this paper has some limits in not identifying how Japanese perception of infectious diseases were culturally adaptive to sciencebased hygienic programs the Meiji administrators had installed.
Communicable Diseases/*history ; Disease Transmission, Infectious/*history ; Germany ; History, 19th Century ; History, 20th Century ; Hygiene/*history ; Japan ; Philosophy, Medical ; Public Health Administration/*history ; State Medicine/*history

Koreans had an ill feeling against the only public isolation hospital, and their ill feeling was a cause the movement for establishing a private isolation hospital. The bad seating capacity and the nearness to downtown of public isolation hospital, and some violence caused in the course of taking a patient to the public isolation hospital were concrete causes of the movement for establishing a private isolation hospital. The three purposes of the movement for establishing a private isolation hospital are as follows. First, for the purpose of removing the national ill feeling, Koreans had to establish the isolation hospital by themselves. Second, for the purpose of curing the patients, doctors needed to use Oriental medicine together. Third, for the purpose of doing away with the anxiety of infection, the isolation hospital had to be located in a distant place from downtown. The movement for establishing a private isolation hospital didn't succeed. It only ended up establishing a contagious ward in Severance hospital. Because whenever an isolation hospital was planned to be constructed somehere, the residents worrying about the infection opposed to the construction, and enough money didn't be gathered. Abve all, rich pro-Japanese men didn't contribute enough money. The middle and lower classes contributed almost all of the money. The movement for estabishing a private isolation hospital was the extension of anti-Japanese national feeling that sprung from the March 1st movement. In view of strenghtening Korean ability, the movement for establishing a private isolation hospital had a common cause with the Shilryokyangsong movement in the early 1920s.
Cholera/*history ; Colonialism/*history ; Communicable Diseases/*history ; English Abstract ; History of Medicine, 20th Cent. ; Hospitals, Public/*history ; Hospitals, Special/*history ; Human ; Japan ; Korea ; Patient Isolation/*history ; Politics

This paper purports to identify and analyze the medical information of the frontline soldiers in the Northwest borderland provinces of Han Dynasty, especially Juyan and Dunhuang region, through an heuristic reading of the Juyan Bamboo Slips and the Dunhuang Bamboo Slips of the Han Dynasty. My findings are as follows. The most frequent disease found in the bamboo slips was the external injury. The injury of the frontline soldiers mainly occurred from the quarrels among armed soldiers using weapons. The bamboo slips also demonstrate that the quarrels usually arose due to the fierce tension caused by the frontier line service such as heavy guard activity and labour duty. Undernourishment and chronic stress the soldiers suffered might be another reasons. The second most common disease harassing the soldiers was exogenous febrile disease. In most cases reviewed in this paper, the exogenous febrile disease was usually concurrent with complex symptoms such as chills, fever, headache, etc. The bamboo slips show that the exogenous febrile disease was related to the harsh climate of the Northwest provinces, featuring extremely dry weather and the large magnitude of diurnal temperature fluctuations. In addition, the annual temperature range in the Northwest province was huge, fluctuating between very cold and dry winter and very hot and dry summer. The third most common disease this study identified was the disorder of the digestive system and respiratory system. However, these two types of disease were virtually indistinguishable in the bamboo slips, because the ancient Chinese chroniclers did not distinguish them, usually dubbing both diseases simply 'abdominal pain.' It should be mentioned that a few slips mention contagious disease such as dysentery and dermatolosis, and sudden death, as well. Overall, the bamboo slips demonstrate extremely poor status of the soldiers' heath condition and poor medical environment surrounding the soldiers stationing in the Northwest borderland military camps. The records also show that acupuncture, applying a plaster, drugs were the most common medical treatment. Drugs among them was the most frequently used. Whereas Acupuncture, applying a plaster were very rarely used. Medication has been used in three ways: powdered medicine, medicinal decoction and pill. Medicinal decoction was the most commonly used way.
China/epidemiology ; Climate ; Communicable Disease Control/history ; Communicable Diseases/epidemiology/etiology/history ; Digestive System Diseases/epidemiology/etiology/history/prevention & control ; History, Ancient ; Humans ; Military Medicine/*history/statistics & numerical data ; Military Personnel/*history ; Wounds and Injuries/epidemiology/etiology/history/prevention & control

This study clarifies the causes of the repetitive occurrences of such phenomena as rinderpest, epidemic, famine, and tiger disasters recorded in the Joseon Dynasty Chronicle and the Seungjeongwon Journals in the period of great catastrophe, the late 17th century in which the great Gyeongsin famine (1670~1671) and the great Eulbyeong famine (1695~1696) occurred, from the perspective that they were biological exchanges caused by the new arrival of rinderpest in the early 17th century. It is an objection to the achievements by existing studies which suggest that the great catastrophes occurring in the late 17th century are evidence of phenomena in a little ice age. First of all, rinderpest has had influence on East Asia as it had been spread from certain areas in Machuria in May 1636 through Joseon, where it raged throughout the nation, and then to the west part of Japan. The new arrival of rinderpest was indigenized in Joseon, where it was localized and spread periodically while it was adjusted to changes in the population of cattle with immunity in accordance with their life spans and reproduction rates. As the new rinderpest, which showed high pathogenicity in the early 17th century, was indigenized with its high mortality and continued until the late 17th century, it broke out periodically in general. Contrastively, epidemics like smallpox and measles that were indigenized as routine ones had occurred constantly from far past times. As a result, the rinderpest, which tried a new indigenization, and the human epidemics, which had been already indigenized long ago, were unexpectedly overlapped in their breakout, and hence great changes were noticed in the aspects of the human casualty due to epidemics. The outbreak of rinderpest resulted in famine due to lack of farming cattle, and the famine caused epidemics among people. The casualty of the human population due to the epidemics in turn led to negligence of farming cattle, which constituted factors that triggered rage and epidemics of rinderpest. The more the number of sources of infection and hosts with low immunity increased, the more lost human resources and farming cattle were lost, which led to a great famine. The periodic outbreak of the rinderpester along with the routine prevalence of various epidemics in the 17thcentury also had influenced on domestic and wild animals. Due to these phenomenon, full-fledged famines occurred that were incomparable with earlier ones. The number of domestic animals that were neglected by people who, faced with famines, were not able to take care of them was increased, and this might have brought about the rage of epidemics like rinderpest in domestic animals like cattle. The great Gyeongsin and Eulbyeong famines due to reoccurrence of the rinderpest in the late 17th century linked rinderpester, epidemics and great famines so that they interacted with each other. Furthermore, the recurring cycle of epidemics-famines-rinderpest-great famines constituted a great cycle with synergy, which resulted in eco-economic-historical great catastrophes accompanied by large scale casualties. Therefore, the Gyeongsin and Eulbyeong famines occurring in the late 17th century can be treated as events caused by the repetition of various periodic disastrous factors generated in 1670~1671 and in 1695~1696 respectively, and particularly as phenomena caused by biological exchanges based on rinderpester., rather than as little ice age phenomena due to relatively long term temperature lowering.
Animals ; Cattle ; Communicable Diseases/epidemiology/etiology/*history ; Epidemics/*history ; History, 17th Century ; Korea/epidemiology ; Population Dynamics ; Rinderpest/epidemiology/*history/virology ; Starvation/epidemiology/etiology/*history ; Tigers/physiology

Through the cases of approximately 80 females in the case records of traditional physician Yi Sugwi (1664-1740?), the present study divided and reclassified the lives and diseases of females during the latter half of the Joseon Dynasty into childhood, obstetrics- and gynecology-related problems in adulthood, other diseases in adulthood, and old age and analyzed them. According to the results, female children were treated less preciously than were male children so that treatments by traditional physicians were sought out less when they were ill than in the case of male children, and acute infectious diseases were the most serious health problems. In the process of receiving treatment from traditional physicians as adults, females came in contact with traditional physicians, who were male, when necessary including face-to-face sessions and the reception of pulse examination but the yangban (literati-official) class practiced sex segregation as much as possible while the lower classes were considerably free from such restrictions. For female adults, the most serious health issues were pregnancy and childbirth so that they received help from traditional physicians and midwives when there were problems. Traditional physicians determined females' pregnancy and the health of fetuses and pregnant women through pulse examinations and medication and actively responded to diverse problems that surfaced in the process with medication and other treatments. Acute infectious diseases, too, were serious diseases suffered by females, and problems involving cold damage and the digestive system were among diseases frequently suffered by females in adulthood and old age. In old age, females often became ill in the arduous process of dealing with the deaths of adult descendants, siblings, and spouses, and tumors were among the major causes of their deaths. The deaths of those aged 70 or above were accepted as quite natural. Aged females endeavored to maintain their health and played the role of elders giving care to their descendants.
Adolescent ; Adult ; Aged ; Child ; Child, Preschool ; Communicable Diseases/etiology/*history/therapy ; Delivery, Obstetric/*history ; Female ; Gynecology/*history ; History, 17th Century ; History, 18th Century ; Humans ; Infant ; Infant, Newborn ; Korea ; Middle Aged ; Obstetrics/*history ; Young Adult

Pandemic influenza has posed an increasing threat to public health worldwide in the last decade. In the 20th century, three human pandemic influenza outbreaks occurred in 1918, 1957 and 1968, causing significant mortality. A number of hypotheses have been proposed for the emergence and development of pandemic viruses, including direct introduction into humans from an avian origin and reassortment between avian and previously circulating human viruses, either directly in humans or via an intermediate mammalian host. However, the evolutionary history of the pandemic viruses has been controversial, largely due to the lack of background genetic information and rigorous phylogenetic analyses. The pandemic that emerged in early April 2009 in North America provides a unique opportunity to investigate its emergence and development both in human and animal aspects. Recent genetic analyses of data accumulated through long-term influenza surveillance provided insights into the emergence of this novel pandemic virus. In this review, we summarise the recent literature that describes the evolutionary pathway of the pandemic viruses. We also discuss the implications of these findings on the early detection and control of future pandemics.
Animals ; Birds ; virology ; Communicable Diseases, Emerging ; epidemiology ; history ; virology ; Evolution, Molecular ; History, 20th Century ; History, 21st Century ; Humans ; Influenza A Virus, H1N1 Subtype ; genetics ; Influenza A Virus, H3N2 Subtype ; genetics ; Influenza in Birds ; epidemiology ; history ; virology ; Influenza, Human ; epidemiology ; history ; virology ; Pandemics ; history

Vaccination is regarded as one of the biggest triumphs in the history of medicine. We are living in the most successful period of vaccine development. The accumulation of multidisciplinary knowledge and the investment of massive funding have enabled the development of vaccines against many infectious diseases as well as other diseases including malignant tumors. The paradigm of clinical vaccine evaluation and licensure has also been modernized based on scientific improvements and historical experience. However, there remain a number of hurdles to overcome. Continuous efforts are focused on increasing the efficacy and reducing the risks related to vaccine use. Cutting-edge knowledge about immunology and microbiology is being rapidly translated to vaccine development. Thus, physicians and others involved in the clinical development of vaccines should have sufficient understanding of the recent developmental trends in vaccination and the diseases of interest.
Allergy and Immunology ; Communicable Diseases ; Financial Management ; History of Medicine ; Investments ; Licensure ; Vaccination ; Vaccines

Zoonoses are diseases caused by the agents that are transmitted between vertebrate animals and human. It is the interaction between agents, host, and the environment they share that determines whether or not infection will be successful. Zoonotic diseases usually have a wide range of host and are particularly important sources of emerging new infectious diseases in human. From an evolutionary point of view, infections in humans and in other animals share common origins. Zoonotic agents are extremely variable in their host specificity and their impact on individuals and host population. The control of zoonoses depends on attempts to reduce vector populations of to limit contacts with reservoir species. In most instances, however, the control efforts require an environmental or human behavioral modification in addition to direct efforts to reduce the size of the vector population. In this article, I described the common natural history and ecologic characteristics of zoonoses, and explained why we should keep an eye on the change in zoonoses with emerging infections. And I also introduced the recent change in the incidence of notifiable zoonotic diseases among animals and humans in Korea, and the principle of control and prevention of zoonoses.
Animals ; Communicable Diseases ; Epidemiology* ; Host Specificity ; Humans ; Incidence ; Korea ; Natural History ; Vertebrates ; Zoonoses*

There has been continuous effort to prevent transfusion-transmitted infection (TTI). Strategies to prevent TTI can be divided into two components: first, determining donor eligibility, and second, managing bacterial contamination of blood products. To determine donor eligibility, medical history taking and screening tests for infectious diseases should be performed. To prevent bacterial contamination, blood collection process should be aseptic, tests for bacterial detection should be performed, and an application of pathogen reduction technology should also be considered. In this review, screening test items and methods, including nucleic acid amplification tests for determining donor eligibility, and precautions for blood collection, bacterial detection methods, and pathogen reduction technology for the prevention of bacterial contamination of blood products were discussed in detail.
Communicable Diseases ; Donor Selection ; Humans ; Mass Screening ; Medical History Taking ; Nucleic Acid Amplification Techniques ; Tissue Donors