1.Clinical observation on combination of acupuncture with medication for treatment of spontaneous tremor.
Li-Hua CHEN ; Qin CHEN ; Min CHEN
Chinese Acupuncture & Moxibustion 2006;26(10):701-703
OBJECTIVETo observe clinical therapeutic effect and safety of combination of acupuncture with medication for treatment of spontaneous tremor.
METHODSWith randomized controlled trial method, 26 cases of spontaneous tremor were divided into a treatment group (n = 13) treated with acupuncture plus western medicine, and a control group (n = 13) treated with simple western medicine. They were treated for 6 weeks. Scores of tremor before and after treatment and adverse effects were investigated.
RESULTSThe total effective rate of 84.6% in the treatment group was better than 61.5% in the control group (P < 0.05) and there was less adverse effects in the treatment group.
CONCLUSIONCombination of acupuncture with medication is a safe and effective therapy for spontaneous tremor.
Acupuncture Therapy ; Combined Modality Therapy ; Drug-Related Side Effects and Adverse Reactions ; Humans ; Treatment Outcome ; Tremor
2.Safety evaluation of Chinese medicine on tumor therapy.
Rui LIU ; Bao-Jin HUA ; Jie LI
China Journal of Chinese Materia Medica 2013;38(23):4181-4184
As a characteristic tumor therapy in China, Chinese medicine (CM) plays an important position in comprehensive treatment of tumor. It's a critical issue of objective realization, analysis and evaluation of CM safety for scientific decision-making in tumor safe medication and it also is a pivotal issue which affects the international communication. The safety evaluation of CM includes three phases: pre-clinical safety evaluation, clinical trials (micro-dose studies and traditional clinical trials) and post-marketing CM safety assessment. The key point of evaluation should be distinguished among different stages and various types of CM (such as classic formulas, Chinese herbal extracts, etc). Emphasis should be given to chronic toxicity when evaluating oral Chinese herbal , microdose studies and quality control must be underlined while injection is evaluated and more attention should be pay to the dose-effect relationship and time-effect relationship when turned to toxic Chinese medicine , and so as for the toxicity grading study. Moreover, we should constantly improve CM safety assessment method in various stages of tumor treatment, such as introducing the concept of syndrome classification theory, bringing in metabonomics and real-world research method which are similar to the CM therapeutic concept. Most importantly, we must keep its own feature of CM theory when we learn the concept of safety evaluation from abroad. Actively exploring the anti-tumor medicine safety evaluation methods and strategies is of great significance for clinical and experimental research, and it can provide supportability platform to CM's international communication.
Animals
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Combined Modality Therapy
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Humans
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Medicine, Chinese Traditional
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adverse effects
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methods
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Neoplasms
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therapy
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Safety
3.Clinical efficacy and safety of limited internal fixation combined with external fixation for Pilon fracture: A systematic review and meta-analysis.
Shao-Bo ZHANG ; Yi-Bao ZHANG ; Sheng-Hong WANG ; Hua ZHANG ; Peng LIU ; Wei ZHANG ; Jing-Lin MA ; Jing WANG
Chinese Journal of Traumatology 2017;20(2):94-98
PURPOSETo compare the clinical efficacy and complications of limited internal fixation combined with external fixation (LIFEF) and open reduction and internal fixation (ORIF) in the treatment of Pilon fracture.
METHODSWe searched databases including Pubmed, Embase, Web of science, Cochrane Library and China Biology Medicine disc for the studies comparing clinical efficacy and complications of LIFEF and ORIF in the treatment of Pilon fracture. The clinical efficacy was evaluated by the rate of nonunion, malunion/delayed union and the excellent/good rate assessed by Mazur ankle score. The complications including infections and arthritis symptoms after surgery were also investigated.
RESULTSNine trials including 498 pilon fractures of 494 patients were identified. The meta-analysis found no significant differences in nonunion rate (RR = 1.60, 95% CI: 0.66 to 3.86, p = 0.30), and the excellent/good rate (RR = 0.95, 95% CI: 0.86 to 1.04, p = 0.28) between LIFEF group and ORIF group. For assessment of infections, there were significant differences in the rate of deep infection (RR = 2.18, 95% CI: 1.34 to 3.55, p = 0.002), and the rate of arthritis (RR = 1.26, 95% CI: 1.03 to 1.53, p = 0.02) between LIFEF group and ORIF group.
CONCLUSIONLIFEF has similar effect as ORIF in the treatment of pilon fractures, however, LIFEF group has significantly higher risk of complications than ORIF group does. So LIFEF is not recommended in the treatment of pilon fracture.
Combined Modality Therapy ; External Fixators ; Fracture Fixation, Internal ; adverse effects ; methods ; Humans ; Tibial Fractures ; surgery
4.Neoadjuvant therapy in pancreatic cancer.
Acta Academiae Medicinae Sinicae 2005;27(5):644-647
Pancreatic cancer remains a major troublesome clinical problem, with conventional cancer treatments having little impact on disease course. The extent of disease is often classified as localized, locally advanced, and metastatic. Radical operation is the most effective method, but only 15%-20% of patients have resectable disease, and around 20% of them survive to 5 years. For locally advanced, unresectable, and metastatic diseases, palliative treatment is more appropriate, but the median survival in these patients is less than 6 months and the 5-year survival rates are even lower than 4%. Neoadjuvant therapy has been gradually accepted in breast cancer and gastroenterological cancer, and its value in pancreatic cancer has attracted increasing interests. This paper reviews recent advances of neoadjuvant therapy in pancreatic cancer.
Adenocarcinoma
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therapy
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Chemotherapy, Adjuvant
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adverse effects
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methods
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Combined Modality Therapy
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Humans
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Neoadjuvant Therapy
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adverse effects
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methods
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Pancreatic Neoplasms
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therapy
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Radiotherapy, Adjuvant
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adverse effects
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methods
5.Short-term curative effect of electroacupuncture as an adjunctive treatment on schizophrenia.
Yao FENG-JU ; Sun FU-GEN ; Zhang ZHI-HUA
Chinese Journal of Integrated Traditional and Western Medicine 2006;26(3):253-255
OBJECTIVETo compare the short-term curative effect of clozapine (CZ) and its combination with electroacupuncture (EA) in treating schizophrenia.
METHODSNinety schizophrenia patients were randomly divided into two groups equally: the EA group treated with combination of CZ (200 - 300 mg/d in mean) and EA, and the CZ group treated with CZ alone. The effects of treatment were evaluated with PANSS, CGI and TESS before and at the 2th, 4th, 6th and 8th weekend of the treatment.
RESULTSThe initiation of effect in the two groups was the same, the total effective rate was 75% in the EA group and 73% in the CZ group. However, somatic complaint was lower and compliance was higher in the EA group than that in the CZ group respectively.
CONCLUSIONWith the effect equal to CZ, combination of CZ and EA shows higher compliance in treating schizophrenia, which would be beneficial in the later stage treatment for consolidation.
Acupuncture Therapy ; Adolescent ; Adult ; Clozapine ; adverse effects ; therapeutic use ; Combined Modality Therapy ; Electroacupuncture ; Female ; Humans ; Male ; Middle Aged ; Schizophrenia ; therapy
6.Research Progress of Pharmacological Therapy and Nutritional Support for Cachexia in Lung Cancer Patients.
Jiemin WANG ; Weihui JIA ; Danyang LI ; Yanmei SONG ; Ningxin SUN ; Ke YANG ; Hongli LI ; Chonggao YIN
Chinese Journal of Lung Cancer 2022;25(6):420-424
Cachexia is a common complication in patients with lung cancer. It aggravates the toxic and side effects of chemotherapy, hinders the treatment plan, weakens the responsiveness of chemotherapy, reduces the quality of life, increases complications and mortality, and seriously endangers the physical and mental health of patients with lung cancer. The causes and pathogenesis of tumor cachexia are extremely complex, which makes its treatment difficult and complex. Controlling cachexia in lung cancer patients requires many means such as anti-tumor therapy, inhibition of inflammatory response, nutritional support, physical exercise, and relief of symptoms to exert the synergistic effect of multimodal therapy against multiple mechanisms of tumor cachexia. To date, there has been a consensus within the discipline that no single therapy can control the development of cachexia. Some therapies have made some progress, but they need to be implemented in combination with multimodal therapy after fully assessing the individual characteristics of lung cancer patients. This article reviews the application of drug therapy and nutritional support in lung cancer patients, and looks forward to the research direction of cachexia control in lung cancer patients.
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Cachexia/therapy*
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Combined Modality Therapy
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Humans
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Lung Neoplasms/drug therapy*
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Neoplasms/complications*
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Nutritional Support/adverse effects*
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Quality of Life
7.Partial mastectomy with axillary lymph node dissection and radiotherapy as a new treatment modality of breast cancer (I).
Hy De LEE ; Chang Ok SUH ; Ki Keun OH ; Hee Boong PARK ; Hoon Sang CHI ; Byong Ro KIM ; Jin Sik MIN
Yonsei Medical Journal 1992;33(3):272-276
This is the first preliminary report among two consecutive papers. Partial mastectomy(PM), axillary lymph node dissection(AD) and radiotherapy (RT) were performed on seventeen operable breast cancer patients who had been admitted from April 1991 to March 1992 to the department of surgery, Yongdong Severance Hospital for improved cosmetic appearance and better survival rate. Of seventeen patients, 47% were T1 lesion and 76% were stage I and II. Extensive intraductal component(EIC) within or around the tumor was also analyzed. Twenty nine per cent of the patients were EIC positive. The mean number of axillary lymph nodes was 21.5 after PM with AD and 20.5 after mastectomy. For radiotherapy, 4,500 rad was delivered to the breast parenchyma and 1,600 rad of boost to the primary tumor site using the electron beam method after surgery. All patients have since been living well without any local recurrence and were satisfied with breast preservation for the one-year follow-up period. We concluded that the PM, AD and RT can be another surgical treatment modality of breast cancer. A longer follow-up data will be followed on the second paper.
Breast Neoplasms/radiotherapy/surgery/*therapy
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Combined Modality Therapy
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Female
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Human
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*Lymph Node Excision
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*Mastectomy, Segmental
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Radiotherapy/adverse effects
8.Integrated treatment for priapism caused by circumcision: a case report.
Bao-fang JIN ; Yu-feng HUANG ; Chang-an SHAO ; Xin-yi XIA ; Feng-gang GUAN ; Guang LI ; Jie WANG
National Journal of Andrology 2005;11(7):544-547
Priapism is rare on clinical condition with complicated pathogenesis which is very difficult to cure. The paper reported a case of a long-time priapism, complicated local skin necrosis, which was caused by circumcision. After the failure of routine therapy, we treated the patient with traditional Chinese therapy, such as TCM herbs combined with bone scraping and depletion therapy, and achieved the satisfactory effect.
Adult
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Circumcision, Male
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adverse effects
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Combined Modality Therapy
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Erectile Dysfunction
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etiology
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therapy
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Humans
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Male
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Medicine, Chinese Traditional
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Necrosis
9.Efficacy and safety of tandem autologous stem cell transplantation in multiple myeloma: a retrospective single-center analysis.
Shunquan WU ; Zongjian QIU ; Ting LIN ; Zhijuan ZHU ; Xiaofan LI ; Xianling CHEN ; Ping CHEN ; Yiting WANG ; Rong ZHAN ; Nainong LI
Chinese Medical Journal 2023;136(15):1873-1875
10.Clinical observation on treatment of depression by electro-acupuncture combined with Paroxetine.
Gui-jin ZHANG ; Zhan-yu SHI ; Sen LIU ; Shi-hu GONG ; Ji-qiang LIU ; Ji-shan LIU
Chinese journal of integrative medicine 2007;13(3):228-230
OBJECTIVETo observe the clinical efficacy and adverse reactions of Paroxetine combined with electro-acupuncture (EA) in treating depression.
METHODSForty-two patients with depression were randomly assigned to the observation group (22 patients) treated with EA combined with Paroxetine, and the control group (20 patients) treated with Paroxetine alone, and the therapeutic course for both groups was 6 weeks. The therapeutic efficacy and adverse reactions were evaluated with scores by Hamilton depression scale (HAMD) and treatment emergent symptoms scale (TESS), respectively.
RESULTSHAMD scores determined at the end of the 1st, 2nd, 4th, and 6th week of the treatment course were significantly lower in the observation group than those in the control group (P<0.05). The significant improvement rate evaluated at the end of the 6-week treatment was remarkably higher in the observation group than that in the control group (72.7% vs 40.0%). No significant difference of TESS scores was found between the two groups.
CONCLUSIONEA combined with Paroxetine has better clinical efficacy than that of Paroxetine alone, with milder adverse reaction and quicker initiation of effect.
Adult ; Combined Modality Therapy ; Depression ; drug therapy ; therapy ; Electroacupuncture ; Female ; Humans ; Male ; Paroxetine ; adverse effects ; therapeutic use ; Serotonin Uptake Inhibitors ; adverse effects ; therapeutic use ; Treatment Outcome