No abstract available.
Colorectal Neoplasms* ; Drug Therapy*

No abstract available.
Colorectal Neoplasms* ; Drug Therapy*

Colorectal Neoplasms ; therapy ; Humans

Humans ; Colorectal Neoplasms/therapy* ; China

Colorectal Neoplasms ; therapy ; Humans ; Neoadjuvant Therapy

Insufficient treatment and overtreatment in the management of colorectal cancer greatly influence patients' outcome. The clinicopathological stage of carcinoma located in colon and rectum is different for anatomical differences. The indication of adjuvant chemotherapy varies in colon or rectal cancer. Locally advanced rectal cancer should receive neoadjuvant treatment, however, the optimal regimen is still controversial.
Colorectal Neoplasms ; therapy ; Humans ; Neoadjuvant Therapy

PURPOSE: The purpose of this study was to evaluate the clinicopathological significance of responders with metastatic colorectal cancer treated with oxaliplatin chemotherapy. METHODS: A total of 52 patients with unresectable metastatic colorectal cancer were enrolled for treatment between March 2000 and August 2005. Patients received first line chemotherapy consisted of oxaliplatin 85 mg/m2 or 130 mg/m2 as a 2-hour infusion on day 1, concurrently with leucovorin (LV) 20 mg/m2 as a bolus infusion on day 1~5, followed by continuous infusion of 5-fluorouracil (5-FU) 425 mg/m2 on day 1~5. This treatment was repeated in 2 or 3 week intervals. All responses were assessed after 4 cycles of therapy by independent radiologic experts and categorized into two groups: responder (major reduction of tumor) and non-responder group (no change or progression of the tumor. RESULTS: The response rate was 51.9 percent (27/52 patients). There were no significant differences in clinicopathologic parameters between two groups. The decrease of CEA value after chemotherapy was significantly more frequent in the responder group than in the non-responder group. CONCLUSIONS: We could not find any clinical differences between the two groups, but these results suggest that oxaliplatin chemotherapy has a beneficial effect on tumor shrinkage and serum CEA value can be an indicator for tumor response of oxaliplatin in advanced colorectal cancer.
Colorectal Neoplasms* ; Drug Therapy* ; Fluorouracil ; Humans ; Leucovorin

In the past 20 years, researches regarding colorectal cancer have experienced unprecedented boom in China. However, a seris problems have been exposed, including a rapid increase in morbility, the geographical limitations of tumor screening, nonstandard diagnosis and treatment, very limited mechanism researches, and lack of randomized controlled clinical trials with Chinese characteristics. This article puts forward some main emphases of the current work, based on the above problems and challenges, in order to improve the overall level of the diagnosis and treatment of colorectal cancer in China.
China ; Colorectal Neoplasms ; diagnosis ; therapy ; Humans

Colorectal Neoplasms ; surgery ; therapy ; Humans ; Treatment Outcome

China ; Colorectal Neoplasms/therapy* ; Humans ; Quality Control