1.Prognostic value of Sox2 expression in digestive tract cancers: A meta-analysis.
Xiao-Ming DU ; Liu-Hua WANG ; Xiao-Wen CHEN ; Yi-Xiao LI ; Yu-Cong LI ; Yu-Wen CAO
Journal of Huazhong University of Science and Technology (Medical Sciences) 2016;36(3):305-312
The aim of the present study was to accurately evaluate the association of Sox2 expression with the survival of patients with digestive tract cancers. Relevant literatures were identified by comprehensively searching databases including the Pubmed, Embase, CBMdisc, and Wanfang (up to October 2014). A meta-analysis was performed to clarify the association between Sox2 expression and overall survival or clinicopathological parameters of patients with digestive tract cancers (esophageal, gastric, and colorectal cancers). The results showed a significant association between high Sox2 expression and poor overall survival in patients with digestive tract carcinomas (HR=1.55, 95% CI=1.04-2.31), especially for patients with esophageal cancer (HR=2.04, 95%CI=1.30-3.22), colorectal cancer (HR=1.40, 95% CI=1.04-1.89), and digestive tract adenocarcinoma (HR=1.80, 95% CI=1.12-2.89), for Europeans (HR=1.98, 95% CI=1.44-2.71) or patients who did not receive neoadjuvant treatment (HR=1.73, 95% CI=1.10-2.72). Furthermore, Sox2 over-expression was highly correlated with vascular invasion (OR=1.86, 95% CI=1.25-2.77) and poor differentiation (OR=1.88, 95% CI=1.14-3.08), especially in esophageal and colorectal cancers. In conclusion, Sox2 expression may serve as a novel prognostic factor for patients with digestive tract cancers. Over-expression of Sox2 that is correlated with vascular invasion and poor differentiation suggests poor outcomes of patients with digestive tract cancers.
Antineoplastic Agents
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therapeutic use
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Biomarkers, Tumor
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genetics
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metabolism
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Colorectal Neoplasms
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diagnosis
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drug therapy
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mortality
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pathology
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Esophageal Neoplasms
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diagnosis
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drug therapy
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mortality
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pathology
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Gastrointestinal Tract
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metabolism
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pathology
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Gene Expression
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Humans
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Neoadjuvant Therapy
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methods
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Neoplasm Grading
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Neoplasms, Vascular Tissue
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diagnosis
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drug therapy
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mortality
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secondary
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Prognosis
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SOXB1 Transcription Factors
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genetics
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metabolism
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Stomach Neoplasms
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diagnosis
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drug therapy
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mortality
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pathology
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Survival Analysis
2.Pathophysiological Role of Hormones and Cytokines in Cancer Cachexia.
Hyun Jung KIM ; Han Jo KIM ; Jina YUN ; Kyoung Ha KIM ; Se Hyung KIM ; Sang Cheol LEE ; Sang Byung BAE ; Chan Kyu KIM ; Nam Su LEE ; Kyu Taek LEE ; Seong Kyu PARK ; Jong Ho WON ; Hee Sook PARK ; Dae Sik HONG
Journal of Korean Medical Science 2012;27(2):128-134
We investigated the role of fasting hormones and pro-inflammatory cytokines in cancer patients. Hormones (ghrelin, adiponectin, and leptin) and cytokines (TNF-alpha, IFN-gamma, and IL-6) were measured by ELISA or RIA in lung cancer and colorectal cancer patients before the administration of cancer therapy, and measurements were repeated every 2 months for 6 months. From June 2006 to August 2008, 42 patients (19 with colorectal cancer and 23 with lung cancer) were enrolled. In total, 21 patients were included in the cachexia group and the others served as a comparison group. No significant difference in the initial adiponectin, ghrelin, TNF-alpha, IFN-gamma, or IL-6 level was observed between groups, although leptin was significantly lower in cachectic patients than in the comparison group (15.3 +/- 19.5 vs 80.9 +/- 99.0 pg/mL, P = 0.007). During the follow-up, the patients who showed a > 5% weight gain had higher ghrelin levels after 6 months. Patients exhibiting elevated IL-6 levels typically showed a weight loss > 5% after 6 months. A blunted adiponectin or ghrelin response to weight loss may contribute to cancer cachexia and IL-6 may be responsible for inducing and maintaining cancer cachexia.
Adiponectin/analysis
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Aged
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Antineoplastic Agents/therapeutic use
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Cachexia/*physiopathology
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Colorectal Neoplasms/drug therapy/*metabolism/mortality
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Cytokines/*analysis
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Female
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Follow-Up Studies
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Ghrelin/analysis
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Humans
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Interferon-gamma/analysis/physiology
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Interleukin-6/analysis
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Leptin/analysis
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Lung Neoplasms/drug therapy/*metabolism/mortality
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Male
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Middle Aged
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Peptide Hormones/*analysis
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Prognosis
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Prospective Studies
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Survival Rate
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Tumor Necrosis Factor-alpha/analysis
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Weight Gain
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Weight Loss