No abstract available.
Colorectal Neoplasms, Hereditary Nonpolyposis*

175 patients with 224 rectal sigma colorectal-polyps in ages of 18 months - 77 ages were found by the endoscopy or the rectal-colorectal operation. The ratio of male/female was 1.92. The main and mark symptom is movement total blood (86.3%) single polyp: 80.8%, the small and medium polyps: 87%, polyps with peduncle: 67.9%, gland polyp: 70.9%, polyp changed to cancer: 7.6%.The large polyps without peduncle, with rough surface account for the severe displasia and high rate of changing to cancer
Colorectal Neoplasms, Hereditary Nonpolyposis

No abstract available.
Colorectal Neoplasms, Hereditary Nonpolyposis*

No abstract available.
Colorectal Neoplasms, Hereditary Nonpolyposis*

No abstract available.
Colorectal Neoplasms, Hereditary Nonpolyposis*

No abstract available.
Colorectal Neoplasms, Hereditary Nonpolyposis*

No abstract available.
Colorectal Neoplasms, Hereditary Nonpolyposis* ; Endometrial Neoplasms* ; Female ; Surgeons*

Adult ; Colorectal Neoplasms, Hereditary Nonpolyposis ; genetics ; Humans ; Male ; Pedigree

PURPOSE: The Korean Hereditary Tumor Registry, the first and one of the largest registries of hereditary tumors in Korea, has registered about 500 families with hereditary cancer syndromes. This study evaluates the temporal changes in clinicopathologic features and surgical patterns of Lynch syndrome (LS) patients. MATERIALS AND METHODS: Data on 182 unrelated LS patients were collected retrospectively. The patients were divided into the period 1 group (registered in 1990-2004) and 2 (registered in 2005-2014). The clinical characteristics of the two groups were compared to identify changes over time. RESULTS: The period 1 group included 76 patients; the period 2 group, 106 patients. The mean ages at diagnosis were 45.1 years (range, 13 to 85 years) for group 1 and 49.7 years (range, 20 to 84 years) for group 2 (p=0.015). The TNM stage at diagnosis did not differ significantly-period 1 group: stage 0-I (n=18, 23.7%), II (n=37, 48.7%), III (n=19, 25.0%), and IV (n=2, 2.6%); period 2 group: stage 0-I (n=30, 28.3%), II (n=35, 33.0%), III (n=37, 34.9%), and IV (n=4, 3.8%). Extended resection was more frequently performed (55/76, 72.4%) in the period 1 group than period 2 (49/106, 46.2%) (p=0.001). CONCLUSION: Colorectal cancer in patients with LS registered at the Korean Hereditary Tumor Registry is still diagnosed at an advanced stage, more than two decades after registry's establishment. Segmental resection was more frequently performed in the past decade. A prompt nationwide effort to raise public awareness of hereditary colorectal cancer and to support hereditary cancer registries is required in Korea.
Colorectal Neoplasms ; Colorectal Neoplasms, Hereditary Nonpolyposis* ; Diagnosis ; Humans ; Korea ; Neoplastic Syndromes, Hereditary ; Registries ; Retrospective Studies

Lynch syndrome is the most common inherited colon cancer syndrome. Patients with Lynch syndrome develop a range of cancers including colorectal cancer (CRC) and carry a mutation on one of the mismatched repair (MMR) genes. Although CRC usually occurs after the fourth decade in patients with Lynch syndrome harboring a heterozygous MMR gene mutation, it can occur in children with Lynch syndrome who have a compound heterozygous or homozygous MMR gene mutation. We report a case of CRC in a 13-year-old patient with Lynch syndrome and congenital heart disease. This patient had a heterozygous mutation in MLH1 (an MMR gene), but no compound MMR gene defects, and a K-RAS somatic mutation in the cancer cells.
Adolescent* ; Child ; Colonic Neoplasms ; Colorectal Neoplasms* ; Colorectal Neoplasms, Hereditary Nonpolyposis* ; Female* ; Heart Defects, Congenital ; Humans