1.Clinical analysis of hereditary nonpolyposis colorectal cancer.
Jeong Meen SEO ; Jae Gahb PARK ; Kuk Jin CHOE ; Jin Pok KIM
Journal of the Korean Society of Coloproctology 1992;8(2):111-119
No abstract available.
Colorectal Neoplasms, Hereditary Nonpolyposis*
2.Hereditary nonpolyposis colorectal cancer: report of one case.
Chang Hwa JUNG ; Young Cheol LEE ; Dong Kun KIM ; Sung KIM ; Won Jin CHOI
Journal of the Korean Society of Coloproctology 1992;8(3):297-302
No abstract available.
Colorectal Neoplasms, Hereditary Nonpolyposis*
3.Hereditary nonpolyposis colorectal cancer: report of one case.
Jeong Meen SEO ; Jae Gahb PARK ; Sang Joon KIM ; Jin Pok KIM
Journal of the Korean Society of Coloproctology 1991;7(2):155-162
No abstract available.
Colorectal Neoplasms, Hereditary Nonpolyposis*
4.Hereditary nonpolyposis colorectal cancer: a case report.
Jun Young KIM ; Heung Dae KIM ; Kwang Yun KIM
Journal of the Korean Society of Coloproctology 1992;8(3):287-290
No abstract available.
Colorectal Neoplasms, Hereditary Nonpolyposis*
5.The clinical, endoscopic and histopathological features of the rectal-sigma colorectal polyp
Journal of Practical Medicine 2002;435(11):30-34
175 patients with 224 rectal sigma colorectal-polyps in ages of 18 months - 77 ages were found by the endoscopy or the rectal-colorectal operation. The ratio of male/female was 1.92. The main and mark symptom is movement total blood (86.3%) single polyp: 80.8%, the small and medium polyps: 87%, polyps with peduncle: 67.9%, gland polyp: 70.9%, polyp changed to cancer: 7.6%.The large polyps without peduncle, with rough surface account for the severe displasia and high rate of changing to cancer
Colorectal Neoplasms, Hereditary Nonpolyposis
7.The gate-keeping role of surgeons with regard to endometrial cancers in Lynch syndrome.
Journal of Gynecologic Oncology 2017;28(1):e17-
No abstract available.
Colorectal Neoplasms, Hereditary Nonpolyposis*
;
Endometrial Neoplasms*
;
Female
;
Surgeons*
8.Lynch syndrome in a pedigree.
Chinese Journal of Medical Genetics 2017;34(5):775-776
9.Clinicopathological Features and Type of Surgery for Lynch Syndrome: Changes during the Past Two Decades.
Il Tae SON ; Duck Woo KIM ; Seung Yong JEONG ; Young Kyoung SHIN ; Myong Hoon IHN ; Heung Kwon OH ; Sung Bum KANG ; Kyu Joo PARK ; Jae Hwan OH ; Ja Lok KU ; Jae Gahb PARK
Cancer Research and Treatment 2016;48(2):605-611
PURPOSE: The Korean Hereditary Tumor Registry, the first and one of the largest registries of hereditary tumors in Korea, has registered about 500 families with hereditary cancer syndromes. This study evaluates the temporal changes in clinicopathologic features and surgical patterns of Lynch syndrome (LS) patients. MATERIALS AND METHODS: Data on 182 unrelated LS patients were collected retrospectively. The patients were divided into the period 1 group (registered in 1990-2004) and 2 (registered in 2005-2014). The clinical characteristics of the two groups were compared to identify changes over time. RESULTS: The period 1 group included 76 patients; the period 2 group, 106 patients. The mean ages at diagnosis were 45.1 years (range, 13 to 85 years) for group 1 and 49.7 years (range, 20 to 84 years) for group 2 (p=0.015). The TNM stage at diagnosis did not differ significantly-period 1 group: stage 0-I (n=18, 23.7%), II (n=37, 48.7%), III (n=19, 25.0%), and IV (n=2, 2.6%); period 2 group: stage 0-I (n=30, 28.3%), II (n=35, 33.0%), III (n=37, 34.9%), and IV (n=4, 3.8%). Extended resection was more frequently performed (55/76, 72.4%) in the period 1 group than period 2 (49/106, 46.2%) (p=0.001). CONCLUSION: Colorectal cancer in patients with LS registered at the Korean Hereditary Tumor Registry is still diagnosed at an advanced stage, more than two decades after registry's establishment. Segmental resection was more frequently performed in the past decade. A prompt nationwide effort to raise public awareness of hereditary colorectal cancer and to support hereditary cancer registries is required in Korea.
Colorectal Neoplasms
;
Colorectal Neoplasms, Hereditary Nonpolyposis*
;
Diagnosis
;
Humans
;
Korea
;
Neoplastic Syndromes, Hereditary
;
Registries
;
Retrospective Studies
10.Early onset of colorectal cancer in a 13-year-old girl with Lynch syndrome.
Do Hee AHN ; Jung Hee RHO ; Hann TCHAH ; In Sang JEON
Korean Journal of Pediatrics 2016;59(1):40-42
Lynch syndrome is the most common inherited colon cancer syndrome. Patients with Lynch syndrome develop a range of cancers including colorectal cancer (CRC) and carry a mutation on one of the mismatched repair (MMR) genes. Although CRC usually occurs after the fourth decade in patients with Lynch syndrome harboring a heterozygous MMR gene mutation, it can occur in children with Lynch syndrome who have a compound heterozygous or homozygous MMR gene mutation. We report a case of CRC in a 13-year-old patient with Lynch syndrome and congenital heart disease. This patient had a heterozygous mutation in MLH1 (an MMR gene), but no compound MMR gene defects, and a K-RAS somatic mutation in the cancer cells.
Adolescent*
;
Child
;
Colonic Neoplasms
;
Colorectal Neoplasms*
;
Colorectal Neoplasms, Hereditary Nonpolyposis*
;
Female*
;
Heart Defects, Congenital
;
Humans