1.Epidemiologic study of colon cancer in last 20 years in Tainjin.
Ke-xin CHEN ; Min HE ; Shu-fen DONG ; Ji-fan WANG ; Feng-ju SONG ; Guang-lin WU
Chinese Journal of Preventive Medicine 2004;38(5):356-357
China
;
epidemiology
;
Colonic Neoplasms
;
epidemiology
;
mortality
;
Female
;
Humans
;
Incidence
;
Male
2.Characteristics and Survival of Korean Patients With Colorectal Cancer Based on Data From the Korea Central Cancer Registry Data.
Hyuk HUR ; Chang Mo OH ; Young Joo WON ; Jae Hwan OH ; Nam Kyu KIM
Annals of Coloproctology 2018;34(4):212-221
PURPOSE: The incidence of colorectal cancer (CRC) in Korea has increased remarkably during the past few decades. The present study investigated the characteristics and survival of patients with CRC in Korea as a function of time, tumor distribution, stage, sex, and age. METHODS: We retrieved clinical data on 326,712 CRC patients diagnosed between 1996 and 2015 from the Korea Central Cancer Registry. The incidence and the 5-year relative survival rates were compared across time period, tumor distribution, stage, sex, and age group. RESULTS: The percentage of patients with colon cancer increased from 49.5% in 1996–2000 to 66.4% in 2011–2015 while the percentage of patients with rectal cancer decreased from 50.5% to 33.6%. The 5-year relative survival rates for all CRCs improved from 58.7% in 1996–2000 to 75.0% in 2011–2015. For 1996–2000, survival rates were highest for patients with left-sided colon cancers, followed by those with right-sided, transverse, rectal, rectosigmoid cancers. For 2011–2015, the survival rates for patients with left-sided cancers were highest, followed by those with rectosigmoid, rectal, transverse, and right-sided colon cancers. Patients with local and regional, but not distant, SEER (Surveillance, Epidemiology, and End Results) stage tumors experienced significantly increased survival rates for 2006–2010 and 2011–2015. The proportion of CRC patients by age decreased in the order ≥70, 60–69, 50–59, 40–49, ≤39 years whereas survival rates decreased in the order 50–59, 60–69, 40–49, ≤39, ≥70 years. CONCLUSION: Korean CRC has some distinct characteristics and survival patterns in terms of tumor distribution, stage, sex, and age. With time, survival outcomes have improved for both local and regional, but not distant, stage tumors.
Colonic Neoplasms
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Colorectal Neoplasms*
;
Epidemiology
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Humans
;
Incidence
;
Korea*
;
Rectal Neoplasms
;
Survival Rate
3.Current status of surgical treatment of rectal cancer in China.
Yong YANG ; Han-Yang WANG ; Yong-Kang CHEN ; Jia-Jia CHEN ; Can SONG ; Jin GU
Chinese Medical Journal 2020;133(22):2703-2711
With the changing lifestyle and the acceleration of aging in the Chinese population, the incidence and mortality of colorectal cancer (CRC) have risen in the last decades. On the contrary, the incidence and mortality of CRC have continued to decline in the USA since the 1980s, which is mainly attributed to early screening and standardized diagnosis and treatment. Rectal cancer accounts for the largest proportion of CRC in China, and its treatment regimens are complex. At present, surgical treatment is still the most important treatment for rectal cancer. Since the first Chinese guideline for diagnosis and treatment of CRC was issued in 2010, the fourth version has been revised in 2020. These guidelines have greatly promoted the standardization and internationalization of CRC diagnosis and treatment in China. And with the development of comprehensive treatment methods such as neoadjuvant chemoradiotherapy, targeted therapy, and immunotherapy, the post-operative quality of life and prognosis of patients with rectal cancer have improved. We believe that the inflection point of the rising incidence and mortality of rectal cancer will appear in the near future in China. This article reviewed the current status and research progress on surgical therapy of rectal cancer in China.
China/epidemiology*
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Colonic Neoplasms
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Colorectal Neoplasms
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Humans
;
Quality of Life
;
Rectal Neoplasms/surgery*
4.Association between Diverticulosis and Colonic Neoplasm in Koreans.
Chang Soo CHOI ; Suck Chei CHOI ; Geom Seog SEO ; Eun Young CHO ; Hyang Jung CHO ; Yong Sung KIM ; Ki Hoon KIM ; Tae Hyeon KIM ; Yong Ho NAH
The Korean Journal of Gastroenterology 2007;49(6):364-368
BACKGROUND/AIMS: Although a few published studies have reported on the relationship between diverticulosis and neoplasia in the west, it is not yet examined in Korea. The aim of this study was to determine whether there is an association between diverticulosis and colonic neoplasia. METHODS: We retrospectely analysed the medical records of 3,007 patients (M:F=1.3:1) who underwent colonoscopic examinations from year 2002 to year 2004. Patients who had a history of previous polypectomy, colon resection, or inflammatory bowel diseases were excluded. The size, extent (none, few, or many), and location of diverticuli and polyps were analyzed. RESULTS: Of 2,377 patients, included 57% were male and the mean age was 50.8 year-old. Nine percent of the patient had diverticulosis, 29% had more than one neoplasm, and 6% had advanced neoplasia. Patients with diverticular diseases had higher risks of any neoplasia than those without diverticulum (p=0.03, 37.7% vs. 28.2%). There was no correlation between diverticular diseases and advanced neoplasia. Patients with proximal diverticular diseases had higher risk of any proximal neoplasia than other patients (p<0.01 24.6% vs. 14.3%). Moreover, they had higher risk of proximal advanced neoplasia than others (p=0.01, 4.5% vs. 2%). In addition, comparison of multiple diverticular disease with few or no diverticuli revealed no difference in the risk of any neoplasia. CONCLUSIONS: These data show that the patients with diverticular diseases have more neoplasms than controls without diverticula.
Adult
;
Aged
;
Colonic Neoplasms/*complications/diagnosis/epidemiology
;
Diverticulosis, Colonic/*complications/diagnosis/epidemiology
;
Diverticulum, Colon/epidemiology/etiology
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Female
;
Humans
;
Korea
;
Male
;
Middle Aged
;
Prevalence
;
Retrospective Studies
5.Correlation between chronic constipation and colorectal neoplasms.
Chinese Journal of Gastrointestinal Surgery 2017;20(3):255-257
The correlation between chronic constipation and colorectal neoplasms has been arousing wide interest. There have been a number of domestic and international epidemiological and clinical researches focusing on this issue. Based on these researches, the correlation between constipation and colorectal neoplasms was studied from three aspects: constipation and colorectal polyps; constipation and colorectal cancer; melanosis coli (MC), laxatives and colorectal neoplasms. We find that constipation can significantly increase the incidence of colorectal polyps and constipation does not significantly increase the incidence of colorectal cancer but is one of the risk factors for colorectal cancer. In addition, MC, laxatives and the incidence of colorectal polyps are also closely correlated. Given the fact that colorectal polyps are precancerous lesions, patients with long-term constipation should take less anthraquinone laxatives, and those with colorectal polyps should be followed up periodically.
Anthraquinones
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adverse effects
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Colonic Diseases
;
complications
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Colonic Polyps
;
epidemiology
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Colorectal Neoplasms
;
epidemiology
;
Constipation
;
complications
;
Humans
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Incidence
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Laxatives
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adverse effects
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Melanosis
;
complications
;
epidemiology
;
Risk Factors
7.Analysis of clinical characteristics of gastrointestinal cancer in Heilongjiang province, China 1998 to 2007.
Xiao-ming ZOU ; Xi-shan WANG ; Yun-long LI ; Zheng-xi JIN ; Da-xun PIAO ; Xiao-yang LI ; Da-wei HUANG ; Wei-xin LIU ; Jian-guo ZHANG ; Guo-li ZHANG ; Hao-min ZHANG ; Zhi-gang YU ; Jian ZHANG ; Dong FAN ; Wei-ye LIU ; Ying-wei XUE ; Jun XU
Chinese Journal of Gastrointestinal Surgery 2009;12(6):577-580
OBJECTIVETo provide basic information for epidemiological research of gastrointestinal (GI) malignant tumors.
METHODSData of GI cancer diagnosed in 15 hospitals of Heilongjiang province between January 1998 and December 2007 were analyzed retrospectively. The data mainly involved the age of onset, initial symptoms, pathological types, clinical staging and types of surgical procedure.
RESULTSGastric cancer was the most common type (45.8%) among the 33,540 GI cancer cases, then were rectal cancer (27.3%) and colon cancer (26.8%). Right colon cancer cases were more common than the left ones (1.3:1.0), particularly in people over 80 (2.1:1.0). Only 1.3% of colorectal cancer could be found in age under 30 years old. In patients aged 50 to 70, advanced gastric cancer accounted for 70.6%, advanced colon cancer 73.4% and advanced rectal cancer 72.4%. Well-moderately differentiated adenocarcinoma in early gastric cancer was 49.7%, early colon cancer 77.3% and rectal cancer 83.2%. Patients undergone radical excision in early gastric cancer accounted for 69.1%, advanced gastric cancer 79.9%, left colon cancer 91.9%, right colon cancer 83.9% and in rectal cancer for 88.3%.
CONCLUSIONSPeople aged 50 to 70 tend to get GI cancer in Heilongjiang province. Gastric cancer is the most common GI cancer. Radical excision is the main choice of therapy.
Adult ; Age Distribution ; Aged ; Aged, 80 and over ; China ; epidemiology ; Colonic Neoplasms ; epidemiology ; pathology ; Colorectal Neoplasms ; epidemiology ; pathology ; Female ; Gastrointestinal Neoplasms ; epidemiology ; pathology ; Humans ; Incidence ; Male ; Middle Aged ; Rectal Neoplasms ; epidemiology ; pathology ; Retrospective Studies ; Sex Distribution ; Stomach Neoplasms ; epidemiology ; pathology
8.Usefulness of Polyp and Adenoma Detection Rate in the Proximal and Distal Colon.
Sung Youn CHOI ; Dong Il PARK ; Chang Kyun LEE ; Jae Myung CHA ; Suck Ho LEE ; Young WHANGBO ; Chang Soo EUN ; Dong Soo HAN ; Bo In LEE ; Jeong Eun SHIN
The Korean Journal of Gastroenterology 2014;63(1):11-17
BACKGROUND/AIMS: The polyp detection rate (PDR) has been suggested as a surrogate for adenoma detection rate (ADR). The purpose of this study was to determine the level of agreement between PDR and ADR in the proximal and distal colon. METHODS: A total of 1,937 consecutive, asymptomatic individuals aged 40 years and older who underwent colonoscopies at six academic teaching hospitals in Korea were included in this study. PDR and ADR were calculated for each colonic segment. PDR was compared with ADR in the proximal and distal colon. RESULTS: During 1,937 colonoscopies, 1,862 polyps were removed; 1,421 (76%) were adenomas. The PDR and ADR in the proximal colon was 25.8% and 22.8%, respectively (kappa value=0.917, p=0.26), and that in the distal colon was 28.9% and 22.2%, respectively (p<0.001). There was a strong correlation between PDR and ADR in the proximal colon, but diverged in sigmoid colon and rectum. CONCLUSIONS: PDR and ADR correlate well in the proximal colon, but not in the distal colon, especially sigmoid and rectum. PDR should be measured for each colonic segment when using PDR as a surrogate for ADR. PDR is a valid proxy for ADR in the proximal colon.
Adenoma/*diagnosis/epidemiology
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Adult
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Aged
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Aged, 80 and over
;
Colon/pathology
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Colonic Neoplasms/*diagnosis/epidemiology
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Colonic Polyps/*pathology
;
Colonoscopy
;
Female
;
Hospitals, University
;
Humans
;
Incidence
;
Male
;
Middle Aged
;
Retrospective Studies
9.Disease Prediction Using Ranks of Gene Expressions.
Ki Yeol KIM ; Dong Hyuk KI ; Hyun Cheol CHUNG ; Sun Young RHA
Genomics & Informatics 2008;6(3):136-141
A large number of studies have been performed to identify biomarkers that will allow efficient detection and determination of the precise status of a patient's disease. The use of microarrays to assess biomarker status is expected to improve prediction accuracies, because a whole-genome approach is used. Despite their potential, however, patient samples can differ with respect to biomarker status when analyzed on different platforms, making it more difficult to make accurate predictions, because bias may exist between any two different experimental conditions. Because of this difficulty in experimental standardization of microarray data, it is currently difficult to utilize microarray-based gene sets in the clinic. To address this problem, we propose a method that predicts disease status using gene expression data that are transformed by their ranks, a concept that is easily applied to two datasets that are obtained using different experimental platforms. NCI and colon cancer datasets, which were assessed using both Affymetrix and cDNA microarray platforms, were used for method validation. Our results demonstrate that the proposed method is able to achieve good predictive performance for datasets that are obtained under different experimental conditions.
Bias (Epidemiology)
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Colonic Neoplasms
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Gene Expression
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Humans
;
Oligonucleotide Array Sequence Analysis
;
Biomarkers
10.Clinicopathologic Study of Colorectal Polyps and Obesity in Korean Adults.
Jeong Hoon JI ; Bum Joon PARK ; Young Soo PARK ; Jin Hyeok HWANG ; Sook Hyang CHUNG ; Nayoung KIM ; Dong Ho LEE ; Hyun Chae JUNG ; In Sung SONG
The Korean Journal of Gastroenterology 2007;49(1):10-16
BACKGROUD/AIMS: Obesity is a rising problem in industrialized countries. Numerous epidemiologic studies have shown a positive association between obesity and colorectal polyps. There are few studies investigating the association between colorectal adenomatous polyps and body fat composition in Korea. We tried to examine the relationship between body fatness and colorectal adenomatous polyps in health check-up subjects in Korea. METHODS: Six thousand seven hundred and six routine health check-up subjects, who visited our hospital between March 2002 and April 2005 and underwent distal colon examimation with sigmoidoscopy, were enrolled in this study. Among them, colonoscopy was done in 860 patients to evaluate the entire colon. We tried to reveal the relationship between body mass index (BMI) and size, location, number and histopathological type of polyps. BMI was used as an indicator of obesity. RESULTS: The mean value of BMI in total polyp-free group (23.8+/-2.9) was not different from that of the polyp group (24.5+/-2.8, p=0.09). The frequency of rectosigmoid polyps in obese patients (20.4%) was higher than that in non-obese patients (16.0%, p<0.05). The frequency of adenomatous polyp was not different between obese and non-obese group. Number of polyps (> or =4) correlated well with obesity. Moreover, age and triglyceride level in patients with colonic adenoma were significantly higher than in patients without colonic adenom. CONCLUSIONS: This study shows that obesity is not associated with colonic adenomatous polyp in Korean population. However, we observed that obesity may be associated with rectosigmoid colon polyps. Furthermore, age and triglyceride level might be the risk factors of colonic adenomatous polyps in Korean population.
Adenomatous Polyps/*complications/epidemiology/pathology
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Adult
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Aged
;
Aged, 80 and over
;
Body Mass Index
;
Colonic Neoplasms/*complications/epidemiology/pathology
;
Colonic Polyps/complications/epidemiology/pathology
;
Comorbidity
;
Female
;
Humans
;
Korea
;
Male
;
Middle Aged
;
Obesity/*complications/diagnosis/epidemiology
;
Retrospective Studies
;
Sigmoidoscopy