1.A Case of Reactivated Tuberculous Colitis After 9 Months of Anti-tuberculous Therapy.
You Sun KIM ; Jin Gook HUH ; Il KIM ; Soo Hyung RYU ; Jung Whan LEE ; Jeong Seop MOON
The Korean Journal of Gastroenterology 2004;44(6):337-341
Tuberculous colitis, an important extra-pulmonary tuberculosis, is still prevalent in the developing countries and has been resurging in the Western world. The duration and dose of anti-tuberculous therapy have not yet been clarified in the tuberculous colitis. We experienced a case of tuberculous colitis, which relapsed after 9 months of therapy. A 28-year-old man presented with hematochezia and was diagnosed as tuberculous colitis on the basis of colonoscopic findings. He was treated with anti-tuberculous agents for 9 months successfully. Three months later, however, he complained of hematochezia again, suggesting the relapse of tuberculous colitis. He had taken anti-tuberculous therapy for another 15 months and showed no evidence of relapse. Although anti-tuberculous therapy is efficient for tuberculous colitis, rare cases of reactivation should be reminded.
Adult
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Colitis/*drug therapy/microbiology
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English Abstract
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Humans
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Male
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Recurrence
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Tuberculosis, Gastrointestinal/*drug therapy
2.Pseudomonas aeruginosa as a Potential Cause of Antibiotic-Associated Diarrhea.
Shin Woo KIM ; Kyong Ran PECK ; Sook In JUNG ; Yeon Sook KIM ; Sungmin KIM ; Nam Yong LEE ; Jae Hoon SONG
Journal of Korean Medical Science 2001;16(6):742-744
Although Pseudomonas aeruginosa is not generally considered as a cause of antibiotic-associated diarrhea, several cases of diarrhea caused by P. aeruginosa have been reported. We experienced seven cases of nosocomial diarrhea presumably caused by P. aeruginosa, which was the predominant organism isolated from stool cultures. Clostridium difficile toxin was also positive in one patient. No other potential or recognized enteropathogens were identified from stools. All patients had underlying diseases and had been receiving antibiotics before the diarrheal onset. All of the seven P. aeruginosa isolates were resistant to previously given antibiotics. Diarrhea stopped three days after withdrawal of probable offending antibiotics without specific treatment in two patients. The other five patients having continuous diarrhea despite withdrawal of probable offending antibiotics, were successfully treated with antipseudomonal agents. The median duration of diarrhea after the initiation of treatment was 6.3 days. These data suggest that P. aeruginosa can be a potential cause of antibiotic-associated diarrhea. Further investigations are warranted to evaluate the possible etiologic role of P. aeruginosa in antibiotic-associated diarrhea.
Adult
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Aged
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Antibiotics/*adverse effects
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Colitis/complications/drug therapy
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Cross Infection/complications
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Diarrhea/*chemically induced/*microbiology
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Feces/microbiology
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Female
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Human
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Male
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Middle Age
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Pseudomonas Infections/*complications
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*Pseudomonas aeruginosa
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Retrospective Studies
3.Oral administration of red ginseng powder fermented with probiotic alleviates the severity of dextran-sulfate sodium-induced colitis in a mouse model.
Sun-Hee JANG ; Jisang PARK ; Sae-Hae KIM ; Kyung-Min CHOI ; Eun-Sil KO ; Jeong-Dan CHA ; Young-Ran LEE ; Hyonseok JANG ; Yong-Suk JANG
Chinese Journal of Natural Medicines (English Ed.) 2017;15(3):192-201
Red ginseng is a well-known alternative medicine with anti-inflammatory activity. It exerts pharmacological effects through the transformation of saponin into metabolites by intestinal microbiota. Given that intestinal microflora vary among individuals, the pharmacological effects of red ginseng likely vary among individuals. In order to produce homogeneously effective red ginseng, we prepared probiotic-fermented red ginseng and evaluated its activity using a dextran sulfate sodium (DSS)-induced colitis model in mice. Initial analysis of intestinal damage indicated that the administration of probiotic-fermented red ginseng significantly decreased the severity of colitis, compared with the control and the activity was higher than that induced by oral administration of ginseng powder or probiotics only. Subsequent analysis of the levels of serum IL-6 and TNF-α, inflammatory biomarkers that are increased at the initiation stage of colitis, were significantly decreased in probiotic-fermented red ginseng-treated groups in comparison to the control group. The levels of inflammatory cytokines and mRNAs for inflammatory factors in colorectal tissues were also significantly decreased in probiotic-fermented red ginseng-treated groups. Collectively, oral administration of probiotic-fermented red ginseng reduced the severity of colitis in a mouse model, suggesting that it can be used as a uniformly effective red ginseng product.
Administration, Oral
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Animals
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Colitis
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chemically induced
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drug therapy
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immunology
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Colon
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drug effects
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immunology
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Dextran Sulfate
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adverse effects
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Disease Models, Animal
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Female
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Fermentation
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Humans
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Interleukin-6
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immunology
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Lactobacillus plantarum
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metabolism
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Mice
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Mice, Inbred BALB C
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Panax
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chemistry
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metabolism
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microbiology
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Plant Extracts
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administration & dosage
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chemistry
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metabolism
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Powders
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administration & dosage
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metabolism
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Probiotics
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metabolism
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Tumor Necrosis Factor-alpha
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immunology