3.Acupuncture combined with acupoint catgut embedding sequential therapy for mild and moderate ulcerative colitis.
Yong WEN ; Lei SHI ; Jun LI ; Weiliang DU ; Ye CHEN ; Xiaolin LAN
Chinese Acupuncture & Moxibustion 2018;38(4):353-357
OBJECTIVETo observe the efficacy of acupuncture combined with acupoint catgut embedding sequential therapy and medication for mild and moderate ulcerative colitis.
METHODSOne hundred and twenty patients were randomized into an acupuncture and acupoint catgut embedding sequential therapy group (a combination group) and a mesalazine group, 60 cases in each one. Fifty-seven cases in the combination group and 55 cases in the mesalazine group were included into analysis. In the combination group, acupuncture was applied at Tianshu (ST 25), Shangjuxu (ST 37), Quchi (LI 11) during the activity period, and acupoint catgut embedding was applied at Pishu (BL 20), Zusanli (ST 36), Guanyuan (CV 4) during the alleviate period. The patients in the mesalazine group were treated with mesalazine orally. The treatment was given for 12 weeks. The scores of TCM symptoms, colonoscopy, mucosa healing rate were compared before and after treatment in the two groups. The effects, adverse reactions and the recurrent rates during 1-year follow-up were observed.
RESULTSAfter treatment, the scores of TCM symptoms decreased in the two groups (both <0.05), and the result in the combination group was better than that in the mesalazine group (<0.05). The total effective rate in the combination group was 87.7% (50/57), which was better than 70.9% (39/55) in the mesalazine group (<0.05). The colonoscopy scores decreased after treatment in the two groups (both <0.05). There was no significant difference between the two groups on colonoscopy score and mucosal healing rate [50.9% (29/57) vs 34.5% (19/55), both >0.05]. The recurrent rate in the combination group was 8.5% (4/47),which was lower than 32.4% (11/34) in the mesalazine group (<0.05). No severe adverse reaction was found during the treatment in the two groups.
CONCLUSIONAcupuncture combined with acupoint catgut embedding sequential therapy can improve mild and moderate ulcerative colitis and reduce the recurrent rate.
Acupuncture Points ; Acupuncture Therapy ; Catgut ; Colitis, Ulcerative ; therapy ; Humans
4.Case of ulcerative colitis.
Chinese Acupuncture & Moxibustion 2015;35(3):290-290
5.The Effect of Probiotics in Ulcerative Colitis.
Kyung Hun LEE ; Chang Hwan CHOI
The Korean Journal of Gastroenterology 2012;60(2):67-70
No abstract available.
Colitis, Ulcerative/*therapy
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Humans
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Male
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Probiotics/*therapeutic use
8.Experimental study on action of acupoint embedding thread on ANCA in the rat of ulcerative colitis.
Yang ZOU ; Zhu-Liang ZOU ; Xiao-Fang YANG ; Xiao-Quan ZHOU ; Gui-Zhen OU
Chinese Acupuncture & Moxibustion 2005;25(7):509-512
OBJECTIVETo observe therapeutic effect of acupoint embedding thread therapy on ulcerative colitis and to study the mechanism.
METHODSThe rat model of ulcerative colitis was developed with 2,4-dinitrochlorobenzene method. The 20th day after the end of model development, they were randomly divided into a model group, a salicylazosulfapyridine (SASP) treatment group and an acupoint embedding thread therapy group. The SASP treatment group were treated with intragastrical perfusion of 4.5% SASP suspension, and the acupoint embedding thread therapy group were treated with embedding thread at "Zusanli" (ST 36) and "Shangjuxu" (ST 37). Anti-neutrophil cytoplasmic antibody (ANCA) was detected with indirect immunofluorescence, and the pathological changes were investigated with pathological tissue section technique.
RESULTSThe positive rate of ANCA reached to 62.5% in the rat with ulcerative colitis with significant differences among the 3 groups. After treatment, the positive rate of ANCA was decreased in the two treatment groups (P < 0.05, P < 0.01).
CONCLUSIONAcupoint embedding thread therapy has definite therapeutic effect on ulcerative colitis and the mechanism is possibly related with the decrease of ANCA.
Acupuncture Points ; Animals ; Antibodies, Antineutrophil Cytoplasmic ; Colitis, Ulcerative ; therapy ; Rats
9.Meta-analysis on acupuncture and moxibustion for treatment of ulcerative colitis.
Jing-ping MU ; Huan-gan WU ; Zhi-quan ZHANG ; Hui-rong LIU ; Yi ZHU ; Zheng SHI ; Xiao-mei WANG
Chinese Acupuncture & Moxibustion 2007;27(9):687-690
OBJECTIVETo assess the effectiveness and safety of acupuncture and moxibustion for treatment of ulcerative colitis.
METHODSRandomized controlled trials or clinical controlled trials of acupuncture and moxibustion for interfere of ulcerative colitis in recent 10 years were reviewed and Meta-analysis was made for the literature results.
RESULTSAltogether 11 papers of clinical study were enrolled. Heterogeneous tests were conducted for the results of the 11 studies, as a result, chi2 = 8.55, P = 0.67. The fixed effect model was used for statistical analysis, after combination OR = 3.82, confidence interval of 95% was 2.65-5.52. The rhombus was located at the right side of the medium line. After Z test, Z = 7.14, P < 0.01, the therapeutic effect and the cured rate in the treatment group were significantly higher than those of the control group.
CONCLUSIONThe therapeutic effect of acupuncture and moxibustion on ulcerative colitis is superior to that of western medicine with safety and less adverse reactions.
Acupuncture Therapy ; Colitis, Ulcerative ; therapy ; Humans ; Moxibustion ; Randomized Controlled Trials as Topic
10.Research progress of Shenling Baizhu San and predictive analysis on its quality markers.
Guang-Ying LU ; Xun-Yan XING ; Jia-Yun WANG ; Yuan WANG ; Ke MA ; Shi-Jun WANG
China Journal of Chinese Materia Medica 2022;47(19):5171-5181
Shenling Baizhu San is a classic prescription for replenishing Qi to invigorate the spleen and dispelling dampness to check diarrhea, which mainly treats the syndrome of spleen deficiency and heavy dampness. With the pharmacological effects of regulating immune system, improving lung function and gastrointestinal function, and resisting oxygen, tumor, and inflammation, Shenling Baizhu San is commonly used in modern clinical practice to treat chronic obstructive pulmonary disease, pulmonary fibrosis, bronchial asthma, irritable bowel syndrome, ulcerative colitis, chronic diarrhea, and diabetic, etc. This paper summarized the chemical constituents, pharmacological effects, and clinical application of Shenling Baizhu San in recent years, and predictively analyzed the quality markers of Shenling Baizhu San according to the "five principles" of Q-marker. The Q-markers of Shenling Baizhu San involved ginsenoside Rg_1, ginsenoside Re, ginsenoside Rb_1, pachymic acid, dehydrotumulosic acid, batatasin Ⅰ, batatasin Ⅲ, diosgenin, liensinine, neferine, luteolin, quercetin, glycerol trioleate, β-sitosterol, platycodin D, glycyrrhizic acid, glycyrrhetinic acid, liquiritin, pipecolinic acid, atractylenolide Ⅰ, atractylenolide Ⅲ, and bornyl acetate, which provided references for the quality control and follow-up research of Shenling Baizhu San.
Humans
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Ginsenosides/therapeutic use*
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Drugs, Chinese Herbal/pharmacology*
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Colitis, Ulcerative/drug therapy*
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Diarrhea/drug therapy*