1.Recent Advances in Understanding Colorectal Cancer and Dysplasia Related to Ulcerative Colitis.
The Korean Journal of Gastroenterology 2015;66(6):312-319
Ulcerative colitis is an idiopathic chronic inflammatory bowel disease and its incidence in Korea has rapidly increased over the past two decades. Since ulcerative colitis is associated with increased risk for colorectal cancer, annual or biannual colonoscopy with four quadrant random biopsies at every 10 cm segments has been recommended for surveillance of colitic cancer in patients with long standing left-sided or extensive colitis. Recent epidemiologic data and meta-analysis suggest that the increment of colorectal cancer risk in ulcerative colitis was not larger than that of previous studies. Moreover, in addition to the extent and duration of colitis, other risk factors such as family history of colorectal cancer, primary sclerosing cholangitis, stricture, pseudopolyps, and histologic severity of inflammation have been recognized. As a result, updated guidelines provide surveillance strategies adjusted to the individual patient's risk for colitic cancer. Regarding surveillance method, target biopsy under panchromoendoscopy is preferentially recommended rather than random biopsy.
Cholangitis, Sclerosing/complications
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Colitis, Ulcerative/*complications
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Colon/pathology
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Colorectal Neoplasms/epidemiology/*etiology
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Humans
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Inflammatory Bowel Diseases/complications
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Polyps
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Risk Factors
2.Characteristics of Pediatric Inflammatory Bowel Disease in Korea: Comparison with EUROKIDS Data.
Hyeon Ah LEE ; Jung Yoon SUK ; Sung Youn CHOI ; Eun Ran KIM ; Young Ho KIM ; Chang Kyun LEE ; Kyu Chan HUH ; Kang Moon LEE ; Dong Il PARK
Gut and Liver 2015;9(6):756-760
BACKGROUND/AIMS: Pediatric inflammatory bowel disease (IBD) has been increasing worldwide. The characteristics of pediatric-onset IBD have mainly been reported in Western countries. We investigated the clinical characteristics of pediatric IBD in Korea and compared these with the data from the 5-year European multicenter study of children with new-onset IBD (EUROKIDS registry). METHODS: Children who were diagnosed with IBD between July 1987 and January 2012 were investigated at five Korean university hospitals. Their clinical characteristics were retrospectively evaluated by medical record review. The results were compared with the EUROKIDS data. RESULTS: A total of 30 children with Crohn's disease (CD) and 33 children with ulcerative colitis (UC) were enrolled. In comparison with the EUROKIDS group, Korean pediatric IBD patients showed a male predominance (86.7% vs 59.2%, p=0.002 in CD; 75.8% vs 50%, p=0.003 in UC). Korean pediatric CD patients had a higher prevalence of terminal ileal disease (36.7% vs 16.3%, p=0.004) and perianal disease (33.3% vs 8.2%, p<0.001) than patients in the EUROKIDS group. Korean pediatric UC patients had a higher prevalence of proctitis than patients in the EUROKIDS group. CONCLUSIONS: Our results suggest that the characteristics of Korean pediatric IBD patients and European pediatric IBD patients may be different.
Adolescent
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Anus Diseases/complications/epidemiology/pathology
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Child
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Colitis, Ulcerative/complications/epidemiology/*pathology
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Crohn Disease/complications/epidemiology/*pathology
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Europe/epidemiology
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Female
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Humans
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Ileal Diseases/complications/epidemiology/pathology
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Male
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Prevalence
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Proctitis/epidemiology/etiology
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Registries
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Republic of Korea/epidemiology
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Retrospective Studies
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Sex Factors