1.Ulcerative Colitis and Immunoglobulin G4.
Go KUWATA ; Terumi KAMISAWA ; Koichi KOIZUMI ; Taku TABATA ; Seiichi HARA ; Sawako KURUMA ; Takashi FUJIWARA ; Kazuro CHIBA ; Hideto EGASHIRA ; Junko FUJIWARA ; Takeo ARAKAWA ; Kumiko MOMMA ; Shinichiro HORIGUCHI
Gut and Liver 2014;8(1):29-34
BACKGROUND/AIMS: Ulcerative colitis (UC) is sometimes associated with autoimmune pancreatitis (AIP). Infiltration of immunoglobulin G4 (IgG4)-positive plasma cells is sometimes detected in the colonic mucosa of AIP or UC patients. This study aimed to clarify the relation between UC and IgG4. METHODS: Associations with UC were reviewed in 85 AIP patients. IgG4 immunostaining was performed on biopsy specimens from the colonic mucosa of 14 AIP and 32 UC patients. RESULTS: UC was confirmed in two cases (type 1 AIP, n=1; suspected type 2 AIP, n=1). Abundant infiltration of IgG4-positive plasma cells in the colonic mucosa was detected in the case of suspected type 2 AIP with UC and two cases of type 1 AIP without colitis. Abundant infiltration of IgG4-positive plasma cells was detected in 10 UC cases (IgG4-present, 31%). Although 72% of IgG4-absent UC patients showed mild disease activity, 70% of IgG4-present patients showed moderate to severe disease activity (p<0.05). CONCLUSIONS: UC is sometimes associated with AIP, but it seems that UC is not a manifestation of IgG4-related disease. Infiltration of IgG4-positive plasma cells is sometimes detectable in the colonic mucosa of UC patients and is associated with disease activity.
Adult
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Aged
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Colitis, Ulcerative/*blood/complications
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Colon/*chemistry
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Female
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Humans
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Immunoglobulin G/*analysis
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Intestinal Mucosa/*chemistry
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Male
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Middle Aged
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Pancreatitis/*blood/complications
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Retrospective Studies
2.A Case of Inferior Vena Cava Thrombosis and Acute Pancreatitis in a Patient with Ulcerative Colitis.
Do Hyun SHIN ; Kwang Hyuk LEE ; Chi Hoon KIM ; Kap Hyun KIM ; Sung Hyun PARK ; Dong Kyung CHANG ; Jong Kun LEE ; Kyu Taek LEE
The Korean Journal of Gastroenterology 2010;56(4):255-259
A 21-year-old man admitted complaining of sudden severe epigastric pain for 1 day. He had been diagnosed as ulcerative colitis (UC) and taking mesalazine for two months. UC was in nearly complete remission at admission. He never drank an alcohol, and serum amylase was 377 IU/L. CT scan showed inferior vena cava (IVC) thrombosis in addition to mild acute pancreatitis. To evaluate the cause of acute pancreatitis and IVC thrombosis, magnetic resonance cholangiopancreatogram (MRCP), endoscopic ultrasonogram (EUS), lower extremity Doppler ultrasonogram (US) and blood test of hypercoagulability including factor V, cardiolipin Ab, protein C, protein S1, antithrombin III, and anti phospholipids antibody were performed. There was no abnormality except mild acute pancreatitis and IVC thrombosis in all the tests. He was recommended to stop taking mesalazine and start having anticoagulation therapy. After all symptoms disappeared and amylase returned normal, rechallenge test with mesalazine was done. Flare-up of abdominal pain occurred and the elevation of serum amylase was observed. Ulcerative colitis came to complete remission with short-term steroid monotherapy. Acute pancreatitis and IVC thrombosis were completely resolved after 3-month anticoagulation therapy with no more mesalazine. We postulated that IVC thrombosis occurred due to hypercoagulable status of UC and intra-abdominal inflammation caused by mesalazine-induced pancreatitis.
Acute Disease
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Amylases/blood
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Anti-Inflammatory Agents, Non-Steroidal/*adverse effects/therapeutic use
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Anticoagulants/therapeutic use
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Cholangiopancreatography, Magnetic Resonance
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Colitis, Ulcerative/complications/*diagnosis/drug therapy
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Endosonography
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Humans
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Male
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Mesalamine/*adverse effects/therapeutic use
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Pancreatitis/chemically induced/*diagnosis/ultrasonography
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Tomography, X-Ray Computed
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Ultrasonography, Doppler
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*Vena Cava, Inferior/ultrasonography
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Venous Thrombosis/complications/*diagnosis/drug therapy
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Young Adult