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BACKGROUND: Clostridium difficile is the main etiologic agent of antibiotic-associated diarrhea and the most common cause of hospital-acquired diarrhea. Recently, the incidence of C. difficile infections (CDI) has increased and new highly virulent C. difficile strains have emerged. Therefore, accurate and rapid diagnosis is needed. We compared the results of using chromID C. difficile (chromID CD, bioMerieux, France) with the conventional C. difficile Selective Agar (CDSA; BD, USA) for the isolation of C. difficile. METHODS: A total of 738 stool specimens of suspected CDI patients at the Severance Hospital from July to August 2011 were inoculated onto CDSA. Among them, 104 stool specimens revealed colonies on CDSA that were then re-inoculated onto chromID CD. The stool samples were stored at -20degrees C until the time of the re-inoculation. Cultured agars were interpreted after 24 hrs and 48 hrs, respectively. Species identification was performed on the basis of colony characteristics on agar plates as well as the ATB 32A system (API System SA, France). RESULTS: The recovery rates of CDSA and chromID CD were 30.1% and 77.5% after 24 hrs, and 77.5% and 98.6% after 48 hrs, respectively. All of the C. difficile isolates were recovered as typical gray/black colonies on chromID CD. CONCLUSION: The performance of chromID CD for the isolation of C. difficile was better than that of conventional CDSA. The chromID CD could provide easy and sensitive detection of C. difficile even after 24hrs of incubation.
Agar ; Clostridium ; Clostridium difficile ; Diarrhea ; Humans ; Incidence

7.Does Proton Pump Inhibitor Increase the Clostridium difficile Infection Risk in the Treatment and Prophylaxis of Stress Ulcers than Histanime-2 Receptor Antagonist?.

Chang Soo EUN

Gut and Liver 2017;11(6):739-740

8.Fecal Microbiota Transplantation as a Treatment of Recurrent Clostridium difficile Infection: Where Are We Now and Where Are We Heading?.

Yoon Ji SHIN ; Beom Jae LEE

The Korean Journal of Gastroenterology 2017;69(4):203-205

9.SDS-PAGE profiles of clostridium difficile isolated from patientsand hospital environments.

Bo Moon SHIN ; Eui Chong KIM

Korean Journal of Clinical Pathology 1992;12(2):223-232

10.SDS-PAGE profiles of clostridium difficile isolated from patientsand hospital environments.

Bo Moon SHIN ; Eui Chong KIM

Korean Journal of Clinical Pathology 1992;12(2):223-232

1.Review of clinical and laboratory features of patients to determinethe significance of increased isolation of clostridium difficile.

2.New Treatment Option for Recurrent Clostridium difficile Infection.

3.Clinical significance of clostridium difficile isolated from stoolsof inpatients.

4.Determination of toxin production of clostridium difficile strains isolated from patients with suspected antibiotic associated diarrhea.

5.Successful Resolution of Recurrent Clostridium difficile Infection Using Freeze-Dried, Encapsulated Fecal Microbiota: Pragmatic Cohort Study.

6.Evaluation of a ChromID C. difficile Agar for the Isolation of Clostridium difficile.

7.Does Proton Pump Inhibitor Increase the Clostridium difficile Infection Risk in the Treatment and Prophylaxis of Stress Ulcers than Histanime-2 Receptor Antagonist?.

8.Fecal Microbiota Transplantation as a Treatment of Recurrent Clostridium difficile Infection: Where Are We Now and Where Are We Heading?.

9.SDS-PAGE profiles of clostridium difficile isolated from patientsand hospital environments.

10.SDS-PAGE profiles of clostridium difficile isolated from patientsand hospital environments.

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