1.The current pathobiology and chemotherapy of clonorchiasis.
The Korean Journal of Parasitology 1986;24(Suppl):1-141
This special issue is devoted to a review of the current state of knowledge of clonorchiasis. Sections deal with: the biology of Clonorchis sinensis; geographical distribution, with particular regard to Korea; epidemiology; pathogenesis; clinical features; diagnosis; prevention and control; chemotherapy.
review
;
parasitology-helminth-trematoda
;
Clonorchis sinensis
;
clonorchiasis
;
epidemiology
;
pathogenesis
;
liver
;
diagnosis
;
chemotherapy
;
praziquantel
;
control
;
hetol
;
di
2.A Bile Based Study of Clonorchis sinensis Infections in Patients with Biliary Tract Diseases in Ulsan, Korea.
Yonsei Medical Journal 2005;46(6):794-798
Stool examination is believed to be the most reliable method for detecting Clonorchis sinensis (CS) eggs. However, it has limited value for diagnosing clonorchiasis when the biliary tract is obstructed or when there is a light infection. We evaluated the infection states of CS in patients with biliary tract diseases using a bile sample. From January 2001 to August 2003, 238 patients who had undergone endoscopic biliary drainage were prospectively included in the study. The patients' bile samples were obtained directly from the nasobiliary drainage tube and then analyzed to detect CS eggs. The overall CS egg positive rate was 28.2% (35.4% in males, 19.4% in females). The egg positive rate was similar in all age groups examined: 26.7% in 30-39 years, 25.0% in 40-49 years, 24.4% in 50-59 years, 30.2% in 60-69 years, 35.3% in 70-79 years, and 25.0% in 80 years of age and over. There were no significant differences in the egg positive rate between the disease groups: 32.6% in bile duct cancer, 38.5% in gallbladder cancer, and 26.4% in gallstone diseases. Our results show that the CS infection rate was very high, regardless of the age, gender, and type of diseases of the patients. Although the study population was limited to patients with biliary tract diseases, it is assumed that clonorchiasis is still an endemic disease in Ulsan, Korea.
Korea/epidemiology
;
Humans
;
Clonorchis sinensis/embryology/*isolation & purification
;
Clonorchiasis/complications/*diagnosis
;
Biliary Tract Diseases/*complications
;
Bile/*parasitology
;
Animals
3.Liver Flukes: the Malady Neglected.
Korean Journal of Radiology 2011;12(3):269-279
Liver fluke disease is a chronic parasitic inflammatory disease of the bile ducts. Infection occurs through ingestion of fluke-infested, fresh-water raw fish. The most well-known species that cause human infection are Clonorchis sinensis, Opisthorchis viverrini and Opisthorchis felineus. Adult flukes settle in the small intrahepatic bile ducts and then they live there for 20-30 years. The long-lived flukes cause long-lasting chronic inflammation of the bile ducts and this produces epithelial hyperplasia, periductal fibrosis and bile duct dilatation. The vast majority of patients are asymptomatic, but the patients with heavy infection suffer from lassitude and nonspecific abdominal complaints. The complications are stone formation, recurrent pyogenic cholangitis and cholangiocarcinoma. Approximately 35 million people are infected with liver flukes throughout the world and the exceptionally high incidence of cholangiocarcinoma in some endemic areas is closely related with a high prevalence of liver fluke infection. Considering the impact of this food-borne malady on public health and the severe possible clinical consequences, liver fluke infection should not be forgotten or neglected.
Animals
;
Bile Duct Neoplasms/*diagnosis/epidemiology/*parasitology
;
Bile Ducts, Intrahepatic/*parasitology
;
Biological Markers/analysis
;
Cholangiocarcinoma/*diagnosis/epidemiology/*parasitology
;
Cholangitis/diagnosis/parasitology
;
Clonorchiasis/*complications/*diagnosis/epidemiology/parasitology
;
Clonorchis sinensis
;
Humans
;
Incidence
;
Opisthorchiasis/*complications/*diagnosis/epidemiology/parasitology
;
Opisthorchis
4.Seroprevalence of Tissue Invading Parasitic Infections Diagnosed by ELISA in Korea.
Mi Kyung LEE ; Sung Jong HONG ; Hye Ryoun KIM
Journal of Korean Medical Science 2010;25(9):1272-1276
Seroprevalence of the IgG antibodies for Clonorchis sinensis, Paragonimus westermani, Taenia solium metacestode (cysticercus), and Spirometra erinacei plerocercoid (sparganum) was measured using enzyme-linked immunosorbent assay (ELISA) in sera of patients in Korea from 1993 to 2006. A total of 74,448 specimens referred nationwide from 121 hospitals revealed an IgG positive rate of 7.6% for the 4 parasites. The IgG positive rate (18.7%) for the 4 parasites in 1993 decreased gradually to 6.6% in 2006. Individual positive rate decreased from 5.2% (1993) to 1.6% (2006) for C. sinensis, from 2.8% (1993) to 1.1% (2006) for P. westermani, from 8.3% (1993) to 2.2% (2006) for cysticercus, and from 2.6% (1993) to 1.6% (2006) for sparganum. The positive rate was highest (21.2%) in the group of patients who ranged in age from 50-59 yr old, and in the group that was referred from the Seoul area (55.9%). In conclusion, our results suggest that tissue invading parasitic infections should always be included in differential diagnosis for patients with eosinophilia associated lesions of the central nervous system, liver, and lungs in Korea.
Adolescent
;
Adult
;
Age Factors
;
Aged
;
Aged, 80 and over
;
Animals
;
Antibodies, Helminth/*blood
;
Child
;
Child, Preschool
;
Clonorchiasis/diagnosis/*epidemiology
;
Clonorchis sinensis/immunology/isolation & purification
;
Cysticercosis/diagnosis/*epidemiology
;
Cysticercus/immunology/isolation & purification
;
Diagnosis, Differential
;
Enzyme-Linked Immunosorbent Assay
;
Eosinophilia/immunology
;
Female
;
Humans
;
Immunoglobulin G/blood
;
Infant
;
Male
;
Middle Aged
;
Paragonimiasis/diagnosis/*epidemiology
;
Paragonimus westermani/immunology/isolation & purification
;
Republic of Korea/epidemiology
;
Seroepidemiologic Studies
;
Sparganosis/diagnosis/*epidemiology
;
Sparganum/immunology/isolation & purification
5.Status of common parasitic diseases in Korea in 2019
Journal of the Korean Medical Association 2019;62(8):437-456
This study aimed to determine the status of common parasitic disease in Korea in 2019. Twelve parasitic diseases were selected: toxocariasis, anisakiasis, paragonimiasis, sparganosis, cysticercosis, toxoplasmosis, clonorchiasis, enterobiasis, trichuriasis, trichomoniasis, cryptosporidiosis, and malaria. Their biology, epidemiology, pathogenesis, symptoms and signs, diagnosis, treatment, and prognosis were evaluated. Of the parasitic diseases, toxocariasis was the most prevalent according to serological results. Anisakiasis should be considered when acute gastrointestinal symptoms occur with a recent past history of raw seafood ingestion. Paragonimiasis, sparganosis, and cysticercosis can be diagnosed using an enzyme-linked immunosorbent assay; thus, enzyme-linked immunosorbent assay needs to be performed for suspected cases. Toxoplasmosis and cryptosporidiosis are opportunistic infections. The symptoms and signs are aggravated under immunocompromised conditions. Although the egg positivity rate of Clonorchis sinensis is higher than that of other intestinal parasitic diseases, encountering patients with complaints of symptoms caused by clonorchiasis is rare because the worm burden is low. Trichomoniasis is usually managed by gynecologists; therefore, it should be included in the differential diagnoses of vaginal diseases. The annual number of malaria cases has decreased, although it remains at approximately 500 cases per year. Malaria should be suspected when symptoms such as intermittent fever, headache, and splenomegaly are noted especially when the patients reside near demilitarized zones. Although the prevalence and number of reported cases of parasitic diseases have decreased in Korea, we should consider parasitic diseases in the list of differential diagnoses.
Animals
;
Anisakiasis
;
Biology
;
Clonorchiasis
;
Clonorchis sinensis
;
Cryptosporidiosis
;
Cysticercosis
;
Diagnosis
;
Diagnosis, Differential
;
Eating
;
Enterobiasis
;
Enzyme-Linked Immunosorbent Assay
;
Epidemiology
;
Fever
;
Headache
;
Humans
;
Korea
;
Malaria
;
Opportunistic Infections
;
Ovum
;
Paragonimiasis
;
Parasitic Diseases
;
Prevalence
;
Prognosis
;
Republic of Korea
;
Seafood
;
Sparganosis
;
Splenomegaly
;
Toxocariasis
;
Toxoplasmosis
;
Trichuriasis
;
Vaginal Diseases