No abstract available.
Cleidocranial Dysplasia*

No abstract available.
Cleidocranial Dysplasia*

No abstract available.
Cleidocranial Dysplasia

No abstract available.
Cleidocranial Dysplasia* ; Leukemia*

A case of cleidocranial dysplasia (CCD) was reported and relevant literatures were reviewed. The diagnosis and treatment of this case were discussed.
Cleidocranial Dysplasia ; Humans

Cleidocranial dysplasia (CCD) is an autosomal dominant skeletal dysplasia whose most common features include late closure of fontanelles, absent or hypoplastic clavicles, and dental abnormalities. This disorder is primarily due to mutations in RUNX2 (CBFA1) gene. Here we present a Filipino child with clinical and radiologic features of CCD who was also diagnosed with B-cell acute lymphoblastic leukemia (ALL). On history, the patient’s father and paternal grandfather also presented with short stature and similar facial features. Association of leukemia and CCD has been noted in the literature. Hence, this report adds to the potential role of RUNX2 gene in leukemogenesis. With the potential predisposition to developing leukemia, this provides implications in genetic counselling and possible recommendations for surveillance later on.
Cleidocranial Dysplasia ; Leukemia

Two cases of cleidocranial dysplasia(CCD) were reported and the characteristics of CCD were analyzed. The propositus verification method was used to family members for general health and oral specialized examination. All patients expressed developmental abnormality of crania, teeth and clavicle.
Clavicle ; Cleidocranial Dysplasia ; Humans ; Tooth

The cleidocranial dysostosis is relatively rare congenital and familial disorder with autosomal dominant inheritance. After the first report of a case of this was that of Cutter in 1870, which was quoted from Soule, A., in 1946, Marie and Sainton supplied the name of the Cleidocranial dysostosis with the report of 2 cases of this in 1897. Since that time approximately 350 cases have been described in the literature. This condition is characterized by deficient formation of the clavicle, delayed and imperfect ossification of the cranium and less often involvement of other bones, We experienced 2 cases of this and reported them in this paper with a brief review of the literatures.
Clavicle ; Cleidocranial Dysplasia ; Skull ; Wills

The cleidocranial dysostosis is characterized by deficient formation of the clavicle, delayed and imperfect ossification of the cranium and less often involvement of other bones. The cleidocranial dysostosis is relatively rare congenital and familial disorder with autosomal dominant inheritance. We report one case of cleidocranial dysostosis with a brief review of the literatures
Clavicle ; Cleidocranial Dysplasia ; Skull ; Wills

Cleidocranial dysostosis is a rare herditary disorder affecting bones that develop by intramembranous formation. The classical features include exaggerated development of the transverse diameter of the skull, delay in the ossification of the fontanels, aplasia of the clavicles, and hereditary transmission. Authors report a case of cleidocranial dysostosis in 8 years old boy with brief review of the literatures.
Clavicle ; Cleidocranial Dysplasia ; Humans ; Male ; Skull