Adolescent ; Foot Deformities ; genetics ; Humans ; Male

OBJECTIVETo study the chemical constituents in root of Phlomis medicinalis.

METHODThe compounds were isolated and repeatedly purified on macroporous resin, silica gel column chromatography, TLC and Prep-HPLC and the structures were elucidated by physico-chemical properties and NMR spectra.

RESULTEight compounds were obtained and elucidated as 5-Hydroxy-7-methoxy-4, 6-dimethylphthalide (1), 4-hydroxymethyl-2-furaldehyde (2) and six iridoid glucosides: 6-O-acetyl-shanzhiside methyl ester (3), 8-O-acetyl-shanzhiside methyl ester (4), shanzhiside methyl ester (5), sesamoside (6), phloyoside II (7) and dehydropentstemoside (8).

CONCLUSIONAll the compounds were isolated from the plant for the first time and 1 and 3 were obtained from the plants of Phlomis for the first time.

Benzofurans ; chemistry ; isolation & purification ; Glucosides ; chemistry ; isolation & purification ; Phlomis ; chemistry ; Plant Extracts ; chemistry ; isolation & purification ; Plant Roots ; chemistry ; Plants, Medicinal ; chemistry ; Pyrans ; chemistry ; isolation & purification ; Terpenes ; chemistry ; isolation & purification