No abstract available.
Cimetidine* ; Liver* ; Ranitidine*

The effects of histamine type 2(H2) receptor antagonists, cimetidine and ranitidine, on the induction of contact hypersensitivity and UVB induced suppression of contact hypersensitivity were studied. Our experiment showed that treatment with cimetidine or ranitidine slightly enhanced contact hypersensitivity to DNCB, but the suppression of contact hypersensitivity elicited by UVB were moderatly reversed by ranitidine. These facts suggest that H2-receptor antagonist may be responsible for th blocking histamine induced suppressor factor by acting upon UV-induced suppressor T cell.
Cimetidine ; Dermatitis, Contact* ; Dinitrochlorobenzene ; Histamine ; Ranitidine

In an attempt to evaluate the efficacy ef cimetidine in treatment of erosive gastritis, a praspective study wras done in 9 cases of heworrhagie gastritia, 4 cases yunctiform gastritis, 9 caees verrueous gastritia, and 9 caseis mixed type, Four hundred mg of cimetidine was given in the morning and at bedtime for 3 weeks. Evaluation ef the efficacy was assessed by clinical syinptoms acoring and by endoscopic findings of erosion before treatment, on the 8th day, on the 15th day, and on the 22th day of treatment in all patients. The results were as follows; 1) Clinical sytnptoms in patients with erosive gastritis were epigastric discamfortness(83. 9%), heart burn(80. 0%), indigestion(77, 6%), hunger pain(74.2%), belching(71.0%), anotexla (48.4%) and nausea(45.5%). There was no differenees of symptoms among the type of erosion. 2) Percent decrease in clinical eyxeptoms were; 45% on the 8th day, 68% on the 15th day, 81% on the 22th day of treatment. Ciinical symptoms in patients with punetiform gastritis lasted longer than other typea. 3) Disappearance of the gastric mucossl erosion was seen in 8 cases of hemorrhagic gastritis, 6 case of mixed type, 5 cases of verruceous gastritis, 2 cases of punctiform gastritis, and overall 21 Cases(67.7%) on the 22th day of treatment, endoscopieally. Faur eases af punctiform gastritis were transformed into verrueous gastritis during the treatment. 4) Disappearance of the erosion was observed more frequently in the mueosa of oxyntic area than that of antrum. This study suggests that cimetidine appears to be effective for relief of elinical symptoms in patients with erosive gastritis, and for treatment of hemorrhagic gastritis and erosions in the mucosa of oxyntic area,
Cimetidine* ; Gastritis* ; Heart ; Humans ; Hunger ; Mucous Membrane

PURPOSE: To evaluate the agreement between optical biometry with swept-source optical coherence tomography-based optical biometry (IOLMaster 700) and other devices. METHODS: A total of 137 eyes (78 patients) with cataracts were included in this retrospective study. Axial length (AL), anterior chamber depth (ACD), keratometry, and white-to-white (WTW) distance measured using IOLMaster 700 were compared with results for the following five different biometers: IOLMaster 500, A-scan, automated refractor, manual keratometry, and Galilei G4. Differences and correlations among the devices were assessed using the Bland-Altman plot and intraclass correlation coefficient (ICC). RESULTS: For AL values, the IOLMaster 700, IOLMaster 500, and A-scan measurements showed excellent agreement (all ICC >0.99). For ACD values, ICC of IOLMaster 700 and Galilei G4 was 0.965 but A-scan was poorly correlated with either IOLMaster 700 or Galilei G4. The ICCs of IOLMaster 700 and other devices were all greater than 0.9 for average keratometry, but those of the mean cylinder keratometry were all between 0.7 and 0.8. The mean difference in the WTW distance between the IOLMaster 700 and Galilei G4 was 0.029 mm, but the ICC was 0.525. AL measurements were not possible for 10 eyes with the IOLMaster 500 but were obtained in all eyes with the IOLMaster 700. CONCLUSIONS: In clinical practice, AL, ACD, and average keratometry values of IOLMaster 700 can be used interchangeably with those of the other devices tested. However, the ACD value between IOLMaster 700 and A-scan or the WTW distance between IOLMaster 700 and Galilei G4 are not interchangeable because of clinical and statistical differences in measurements between the devices.
Anterior Chamber ; Biometry* ; Cataract ; Cimetidine* ; Retrospective Studies

BACKGROUND: Variable effectiveness of high dose cimetidine therapy for multiple warts, verruca plana and molluscum contagiosum has been reported. The immunomodulatory actions of cimetidine, an H2-receptor antagonist, and its use in the treatment of viral warts have been described previously but its effectiveness is still debated. OBJECTIVE: The purpose of this study is to evaluate the efficacy and safety of high dose cimetidine therapy for periungual warts. METHODS: Twenty seven patients with periungual warts were treated with high dose oral cimetidine (30~40 mg/kg/ day). RESULTS: Evaluable data was obtained in 20 (male 10, female 10) of the 27 patients enrolled in the study. 19 patients (95% of 20 patients) showed either complete resolution (50% of 20 patients) or partial resolution (45% of 20 patients) of their periungual warts without any side effect. CONCLUSION: Unlike aggressive therapies, oral high dose cimetidine administration is simple and cost effective and does not usually interfere with the patient's work activity or affect his or her social life. Though we can consider that high dose cimetidine therapy is one of the effective therapy for periungual warts, complete remission rate is not so high. Combined therapy with other topical therapy using liquid nitrogen, formic acid, silver nitrate or imiquimod, etc. would also be considered and evaluated for more effective treatment of periungual warts.
Cimetidine* ; Female ; Humans ; Molluscum Contagiosum ; Nitrogen ; Silver Nitrate ; Warts*

PURPOSE: To establish the accuracy of the newly released biometer Ocuscan RxP(R) (Alcon, USA) by comparison with the established Ultrasonic Biometer Model 820(R) (Allergan Humphrey, USA), and to compare the accuracy of contact and immersion biometries. METHODS: This is a prospective study involving 27 patients (40 eyes) who were scheduled for cataract surgery and had axial lengths measured with an Ocuscan RxP(R) biometer using both contact (Method 1) and immersion (Method 2) techniques. As a reference, a contact type Ultrasonic biometer 820(R) (Method 3) was also used. IOL(Intraocular Lens) power for the cataract surgery was calculated using this result. An axial length which would have caused no post-operative refractive error was reversely calculated from the difference of target diopter and post-operative refractive error. This length was compared with the axial lengths obtained via Methods 1, 2 and 3. RESULTS: The means and standard deviations for the measurement sets were compared. Methods 1 and 2 showed no significant difference (23.22+/-0.68, 23.24+/-0.69 mm, p=0.55). The axial length measured by Method 3 was 23.32+/-0.67 mm. The difference between the target refraction and post-operative refractive error was 0.29+/-0.60D. The axial length was reversely calculated from the difference (23.07+/-0.84 mm). The differences between the reversely calculated axial lengths and those of Methods 1, 2 and 3 were 0.15+/-0.31, 0.17+/-0.31 and 0.24+/-0.28 mm, respectively. CONCLUSIONS: Biometric results from Methods 1 and 2 caused less refractive error than did Method 3. The contact and immersion methods are both accurate for IOL power calculation if performed by a well-skilled examiner.
Biometry ; Cataract ; Cimetidine ; Humans ; Immersion ; Prospective Studies ; Refractive Errors ; Ultrasonics

The effect of preanesthetic administration of glycopyrrolate and cimetidine on gastric fluid pH and volume were studied. Forty patients scheduled for elective surgery were fandomly placed into two groups. Patients in group 1 were given glycopyrrolate intramuscularly (0.003 mg/kg) 30-60 minutes before induction of anesthesia, while group 2 patients received glycopyrrolate intramuscularly and 200mg of cimetidine intravenouly 2 hours before induction of anesthesia. Nasogastric tubes were placed and gastric pH and volume were measured. The results showed that patients in group 1 hade a medn gastric pH of 2.428+/-1.378. Twenty five percent of these patients had gastric contents with a pH of 2.428+/-1.378. Twenty five percent of these patients had gastric contents with a pH above 2.5 and a volume greater than 25ml. In contrast, group 2 patients had a mean gastric pH of 5.566+/-1.969, 85 percent had a ph above 2.5 and 15 percent had a volume greater than 25ml. These findings demonstrate that cimetidine markedly increases gastric pH. The authors recoment that patients reciving general anesthesia be given cimetidine preoperatively.
Anesthesia ; Anesthesia, General ; Cimetidine* ; Glycopyrrolate ; Humans ; Hydrogen-Ion Concentration*

This study was designed to evaluate the therapeutic effect of H2 and H2 antihistaminics on dermographism. Twenty four patients with dermographism were allocated on a random to one of the following 3 treatment regimens. A) chlorphenirarnine and cimetidine (H1+H1) B) chlorpheniramine alone (H>) C) cimetidine alone (H) The patients cutaneous response to the dermographometer was assessed at weekly intervals for four weeks. The results were as follows: 1. The combinded treatment with chlorpheniramine and cimetidine was significantly more effective in inhibiting wheal and flare than the cimetidine alone (wheal p<0.01, flare p<0.02). 2. Following comparisions were not statistically significant: chlorpheniramine+ cimetidine vs chlorpheniramine (p>0. 05), chlorpbeniramine alone vs cimetidine alone(p>0.05). 3. Main side effects were drowsiness (3 cases) and mild gastric disturbance (2 cases) on hlorpheniramine alone.
Chlorpheniramine ; Cimetidine ; Histamine H2 Antagonists* ; Humans ; Sleep Stages

This retrospective study was performed to compare refractive outcomes measured by conventional methods and by use of the Lenstar biometer and to investigate the factors affecting intraocular lens (IOL) power calculation with Lenstar with and without IOL-constant optimization. The study included 100 eyes of 86 patients who underwent cataract surgery. Corneal curvature was measured with a manual keratometer (MK), automated keratometer (AK), and the Lenstar biometer, and axial length (AL) was measured by A-scan and Lenstar. Mean numerical error (MNE) and mean absolute error (MAE) were compared between AK and MK with A-scan, and Lenstar with and without optimization. Factors affecting the accuracy of the IOL power calculation by use of Lenstar with and without optimization were analyzed. No significant differences were observed in the MNE or MAE among the devices. The proportion of MAE within 0.5 D was higher for Lenstar with optimization (62.7%) than without optimization (46.2%). The proportion of MAE within 0.5 D was 62% and 58% for MK and AK with A-scan, respectively. Without optimization, the MAE was smaller in eyes with ALs between 23 mm and 25 mm (p=0.03), whereas it was smaller at higher corneal powers when the IOL constant was optimized (>44 D, p=0.03). The IOL power calculations showed no significant differences among the devices, but the results of MAE within 0.5 D by use of Lenstar without optimization were worse than those of conventional methods. The AL influenced the accuracy of refractive outcomes determined by using Lenstar without optimization, and corneal curvature was shown to affect the accuracy of refractive measurements using Lenstar with optimization.
Cataract ; Cimetidine ; Corneal Topography ; Humans ; Lenses, Intraocular ; Retrospective Studies

Treatment of peptic ulceration by suppression of gastric aeid, secretion with the histamine H,-receptor antagonist, cimetidine is now well established. Prior to the availability of ranitidine, cimetidine was the only histamine H2-receptor antagonist available for treatment of duodenal and gastric ulceration. The aim of this study was to compare the efficacy of ranitidine and cimetidine in accelerating the healing of duodenal ulcer. The therapeutic trials comparing ranitidine with cimetidine in a total of 44. out-patients with endoscopically diagnosed duodenal ulcer ivere entered into the study. 28 patients were treated with ranitidine 150mg twiee daily, and 16 patients with cimetidine 200 mg 4 times daily for 4 weeks. Overall endoscopic healing rates were 75%, on ranitidine and 64.3% on cimetidine, and so ranitidine appears to be slightly more effective than cimetidine although too small numbers af patients were studied to detcet any difference between drugs. Aa ranitidine is effective with administration twice daily, patient compliance may be better than with the 4 times daily treatment regimen adopted with cimetidine, though has not yet to be adequately demonstrated. There were no significant side-effects, either ranitidine or cimetidine, to the administration of the drug, except a case of dyspepsia on cimetidine regimen.
Cimetidine ; Duodenal Ulcer ; Dyspepsia ; Histamine ; Humans ; Outpatients ; Patient Compliance ; Peptic Ulcer* ; Ranitidine ; Stomach Ulcer