We experienced a case of the ciliary body neurilemorna in a 26 year old m.an who had progressive visual loss and ocular pain for two years. Neurilemomas are benign tumors and rarely occur within the eyeball. The clinical apearance of the lesion was similar to that presened by choroidal melanoma, therefore they are misdiagnosed as malignant melanoinas, resulting in enucleation. We reviewed the literature on solitary neurilemoma of the uveal tract and analyzed the main clinical and pathological features of the uveal neurilem.oma with this case which successfully treated by iridocyclectomy.
Adult ; Choroid ; Ciliary Body* ; Humans ; Melanoma ; Neurilemmoma

PURPOSE: This study was performed to investigate the morphological change of the iris and ciliary body of human eyes during fetal period. METHODS: Under the Registry of Congenital malformation, fetuses were supplied by the Department of Pathology of Seoul National University. We selected 81 eyes enrolled with the gestational age between 8 and 40 weeks, and examined under light microscope. RESULTS: The development of iris and ciliary body began from 12 weeks. During the gestational age 15-18 weeks, marginal sinus and the fold of iris and ciliary body were formed. At the gestational age 18 weeks, the iris sphincter located in front of marginal sinus was certainly distinguished, and the vessels of ciliary body formed. During the gestational age 19-22 weeks the minor folds of ciliary body were formed between the original it. During the gestational age 23-27 weeks marginal sinus was being diminished and dilator muscle was seen. During the gestational age 28-30 weeks the dilator muscle of iris was certainly developed and the longitudinal and circular muscle of ciliary body were distinguished. During the gestational age 34-40 weeks the adultlike appearance of the iris and ciliary body became apparent. CONCLUSIONS: The mesenchymal cells located in the anterior rim of optic cup began to develop after the gestational age 12 weeks. If the develpment of the iris and ciliary body was arrested around the gestational age 15-22 weeks, the congenital malformation of the iris and ciliary body could appear.
Ciliary Body* ; Fetus ; Gestational Age* ; Humans ; Iris* ; Pathology ; Seoul

A leiomyoma of the ciliary body is a rare tumor that is thought to arise from the neural crest tissue.It is difficult to differentiate this tumor from a uveal melanoma either clinically or pathologically. We performed a complete removal or the mass that had been suspected clinically as an intraocular inflammation or a malignant melanoma.However, it was diagnosed as a leiomyoma by immunohistochemistry and electron microscopy.
Ciliary Body* ; Immunohistochemistry ; Inflammation ; Leiomyoma* ; Melanoma ; Microscopy, Electron ; Neural Crest

Bunazosin is a alpha-1 blocker that is more selective and effective than other alpha-1 receptor blockers. Bunazosin has been shown to lower intraocular pressure but it's mechanism is uncertain. The purpose of this study is to know the morphological changes in the ciliary epithelium by bunazosin. 0.1% Bunazosin was instilled on the eye of the rabbits and the eyes were enucleated on 1, 2, 6 and 24 hours after instillation to find out the tissue response under the electronmicroscopy. As a result, widening of the cell membranes and swelling of the mitochondria were observed in the pigmented and non-pigmented epithelium and these changes were recovered with time and seem to be the morphological changes of bunazosin against aqueous formation in the ciliary body.
Cell Membrane ; Ciliary Body ; Epithelium* ; Intraocular Pressure ; Mitochondria ; Rabbits*

The cyclocryosurgery was done to ten adult albino rabbits in each group respectively. The cryoinstrument(Amoils)was used with carbon dioxide gas, and when applied, it indicated a tip temperature of -60 degrees C. the various cryoprobes were applied at room temperature with its nearest edge 3mm from the limbus, for thirty seconds or one minute, at two or eight equidistant positions. The changes of intraocular pressure ensued thereof was observed and histopathological study of the ciliary bodies was done. The results were as follows: 1. When the cyclocryosurgery was done with 5mm2 cryoprobe for thirty seconds and one minute at eight equidistant positions, the intraocular pressure was reduced 8.7%(2.0mmHg) and 3.4% (0.6mmHg) respectively. Histologically the ciliary process revealed a mild fibros is. 2. When the 16mm2 cryoprobe was applied for one minute at eight places, the intraocular pressure was decreased 30.9%(6.7mm Hg). Histopathologically the ciliary process showed a moderate cystic and hydropic degeneration. 3. When the 50mm2 cryoprobe was applied for one minute at eight positions, the intraocular pressure was reduced 5.3% (0.9mm Hg). Histopathologically moderate fibrosis occurred in the ciliary process. 4. Proportional interrelationship could be proved between the change of intraocular pressure and severity of histopathological findings of the ciliary process.
Adult ; Carbon Dioxide ; Ciliary Body ; Fibrosis ; Humans ; Intraocular Pressure ; Rabbits

Cyclodialysis is characterized by a disruption of the circumferential attachment of the fibers of the meridional ciliary muscle to the scleral spur. Cyclodialysis can lead to a marked chronic hypotony. Prolonged periods of hypotony can result in corneal edema, Descemet`s folds, shallow anterior chamber, cataract formation, chorioretinal folds that can involve the macula, and optic disc edema. The authors experienced a case of traumatic cyclodialysis with a persistent hypotony. We have treated with refixation of the detached ciliary body, by direct cyclopexy. Postoperatively, hypotony was disappeared and visual improvement was achieved.
Anterior Chamber ; Cataract ; Ciliary Body ; Corneal Edema ; Edema

Using ocularluminal methylmethacrylate corrosion casting, we obsesved three-dimentional anterior uveal microcirculation of the rabbit eyes with scanning electron microscope. The two terminal branches of each long posterior ciliary artery turn opposite direction within the iris to run concentric to the pupil; the superior and inferior branches forming the major iridic circle (MIC). Radial branches run both proximally and distally from the MIC, the former distributing to the ciliary process, choroid and ciliary body and the latter distributing to the iris. Venous drainage of the anterior uvea is taken care of by the large iridociliary veins and by marginal capillaries of the process. Each of these drains to the large vessel layer of the choroid and subsquently to the vortex vein.
Capillaries ; Choroid ; Ciliary Arteries ; Ciliary Body ; Corrosion Casting ; Drainage ; Iris ; Methylmethacrylate ; Microcirculation ; Microscopy, Electron, Scanning* ; Pupil ; Uvea ; Veins

Using ocularluminal methylmethacrylate corrosion casting, we obsesved three-dimentional anterior uveal microcirculation of the rabbit eyes with scanning electron microscope. The two terminal branches of each long posterior ciliary artery turn opposite direction within the iris to run concentric to the pupil; the superior and inferior branches forming the major iridic circle (MIC). Radial branches run both proximally and distally from the MIC, the former distributing to the ciliary process, choroid and ciliary body and the latter distributing to the iris. Venous drainage of the anterior uvea is taken care of by the large iridociliary veins and by marginal capillaries of the process. Each of these drains to the large vessel layer of the choroid and subsquently to the vortex vein.
Capillaries ; Choroid ; Ciliary Arteries ; Ciliary Body ; Corrosion Casting ; Drainage ; Iris ; Methylmethacrylate ; Microcirculation ; Microscopy, Electron, Scanning* ; Pupil ; Uvea ; Veins

Injury inflicted to the body by an external force ; inhibition, physical ; Freezing ; Colchicine ; Ciliary Body

Brimonidine(Alphagan)is a relatively selective-adrenoceptor agonist that activates receptor in the ciliary body, which lowers intraoculat pressure by decreasing aqueous production and increasing uveoscleral outflow. We investigated the short-term intraocular pressure lowering effect and side effect of 0.2% brimonidine in 8 eyes in 8 normal volunteers. Brimonidine was administered every 8 hours for 7 days. The intraocular pressure, pupil size, pulsatile ocular blood flow of both eyes, blood pressure, and pulse rate were obtained 2, 4 and 8 hours, and 1 and 7 days after instillation. The mean intraocular pressure was lowered in both eyes. The blood pressure, pulse rate, and pupil size were not changed before and after the instillation. The pulsatile ocular blood flow was not changed either, The only side effect which patients complanined of was nasal stuffiness in two of the patients. We concluded that 0.2% brimonidine is a good ocular hypotensive drug that has an intraocular pressure lowering effect in normal Koreans and also has few side effects.
Blood Pressure ; Ciliary Body ; Healthy Volunteers ; Heart Rate ; Humans ; Intraocular Pressure ; Pupil ; Brimonidine Tartrate