Cilia ; Humans

Recurrent trichiasis is a persistent annoyance and, too often, resists conventional treatment. We tried the application of argon laser in the treatment of trichiasis. The technique involves the destruction of the follicles of the abnormal cilia. This method proved safe, convenient, precise, and effective in 6 cases out of 6. The technique is most suitable when a few fine cilia are involved, but repeated treatment may be required for more and thicker eyelashes.
Argon* ; Cilia ; Eyelashes ; Trichiasis*

No abstract available.
Cilia* ; Demecolcine* ; Lung* ; Salamandridae*

Abetalipoproteinemia ; Cilia ; Humans ; Kartagener Syndrome

As a modality of effective treatment for trichiasis, authors performed experimental study of the radio frequency application(Mehl's method) to the cilia of four rabbit eyes with the different application times(10, 30, 60, 180 seconds). For the control, electrolysis to the cilia of the two eyes, and two eyes without any application were observed histopathologically. Regardless of the radio frequency application time, the radio frequency applied eyelids did not reveal any gross changes, and the selective degenerative changes(pyknotic, vacuolar, and karyorrhaxis) were observed microscopically in the hair regeneration part(internal root sheath of hair, hair matrix, and papillae of hair). In the electrolysed eyelids, gross scar and severe necrotic changes were appeared in microscopic findings. As a result of our observation, it is indicated that the application of radio frequency as a treatment for trichiasis, in compare with the electrolysis, revealed less destructive to the adjacent tissue, with more selective changes on the portion for hair regeneration.
Cicatrix ; Cilia* ; Electrolysis ; Eyelids ; Hair ; Regeneration ; Trichiasis

The primary cilium is a solitary and special organelle that emanates from the cell surface of most mammalian cells, which is anchored to the cell by mother centriole during the interphase and G0 of cell cycle. Recent studies have revealed that the primary cilium is a sensory organelle to receive extracellular signals and plays a key role in the signal transduction and pathogenesis of diseases. This review presents the structure and the forming process of the primary cilium during cell cycle. The signal transductions associated with primary cilium, including platelet-derived growth factor receptor αα, hedgehog, Wnt are discussed and the relevant researches in the future are proposed.
Cilia ; physiology ; Humans ; Signal Transduction ; physiology

Primary cilia and autophagy are two distinct nutrient-sensing machineries required for maintaining intracellular energy homeostasis, either via signal transduction or recycling of macromolecules from cargo breakdown, respectively. Potential correlations between primary cilia and autophagy have been recently suggested and their relationship may increase our understanding of the pathogenesis of human diseases, including ciliopathies and cancer. In this review, we cover the current issues concerning the bidirectional interaction between primary cilia and autophagy and discuss its role in cancer with cilia defect.
Autophagy ; Cilia ; Homeostasis ; Humans ; Recycling ; Signal Transduction

The primary cilium, a sensory organelle that protrudes from the surface of most eukaryotic cells, receives and transduces various critical signals that are essential for normal development and homeostasis. Structural or functional disruption of primary cilia causes a number of human diseases, including cancer. Primary cilia has cross talks with cell cycle and it may act as a cell cycle checkpoint to suppress cancer development. Moreover, primary cilia has cross-regulation with autophagy, which may affect tumor progression. We then discuss the association of the primary cilia with several oncogenic signaling pathways, including Shh, Wnt, Notch and platelet-derived growth factor receptor (PDGFR). Since these signaling pathways are often over-activated in many types of human cancers, primary cilia are likely to play a role in the tumorigenesis by modulating these pathways. Finally, we summarize current progress on the role of cilia during tumorigenesis and the challenges that the cilia-cancer field faces.
Autophagy ; Carcinogenesis ; Cilia ; Homeostasis ; Humans ; Signal Transduction

Tumor necrosis factor (TNF)-alphacan induce ultrastructural changes in cultured human nasal epithelial cells. The aims of this study are to determine the recovery time from the changes induced by TNF-alphaand observe whether various degrees of changes will result in a complete return to normal status. The recovery of cilia was observed on the third day after cessation of adding TNF-alphaand the normalization of secretory cell area was observed on the fifth day. The morphologic changes induced by TNF-alpha were reversible except with the concentration of 100 ng/ml. The results suggest that the ultrastructural changes induced by TNF-alpha are mostly reversible and that this reversibility corresponds with the in vivo state.
Cilia ; Epithelial Cells* ; Humans* ; Tumor Necrosis Factor-alpha*

PURPOSE: The purpose of this study is to evaluate the functional and cosmetic results of V-Y advance-ment flap procedure to correct medial cilio-corneal touch. METHODS: The 8 patients with corneal erosion induced by medial cilio-corneal touch, whose post-operative follow up periods were longer than 3 months, were reviewed retrospectively. RESULTS: All patients underwent V-Y advancement flap procedure. Five patients (10 upper eyelids) under-went slinging procedures and 2 patients (3 lower eyelids) underwent epiblepharon repair simul-taneously. One patient (1 lower eyelid) showed recurrence of cilia touch but reoperation did not undertake. CONCLUSIONS: V-Y advancement flap procedure produced satisfied results functionally and cosmetically.
Cilia ; Follow-Up Studies ; Humans ; Recurrence ; Reoperation ; Retrospective Studies