1.A New Approach to the Treatment of Metastatic Paraganglioma: Sorafenib.
Meral GUNALDI ; Ismail Oguz KARA ; Berna Bozkurt DUMAN ; Cigdem Usul AFSAR ; Melek ERGIN ; Arbil AVCI
Cancer Research and Treatment 2014;46(4):411-414
Paragangliomas are relatively rare chromaffin cell tumors which may be cured through resection. Patients with paragangliomas may develop metastatic diseases. There is no consensus regarding refractory chemotherapy for treatment of metastatic disease. In this report, we presented a case of a 43-year-old woman who was admitted to the hospital with a history of episodic headaches, diaphoresis, and weakness. Elevated plasma catecholamine levels and a right paraaortic mass were observed on computed tomography. The mass was excised, and a diagnosis of paraganglioma was confirmed. After 20 months of follow-up, local recurrence and metastases were detected in the thorax, abdomen, and skeletal system. Plasma and urinary catecholamine levels were high. Chemotherapy was administered, and no improvement was observed. Therefore, following this palliative conventional chemotherapy, sorafenib was administered for three months, and, finally, positron emission tomography showed that the patient's lesions had completely regressed.
Abdomen
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Adult
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Chromaffin Cells
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Consensus
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Diagnosis
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Drug Therapy
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Female
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Follow-Up Studies
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Headache
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Humans
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Neoplasm Metastasis
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Paraganglioma*
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Paraganglioma, Extra-Adrenal
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Pheochromocytoma
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Plasma
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Positron-Emission Tomography
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Recurrence
;
Thorax
2.Coexistence of tuberous sclerosis complex and malignant melanoma.
Meral GÜNALDI ; Semra PAYDAS ; Cigdem Usul AFSAR ; Figen DORAN
Singapore medical journal 2013;54(11):e233-5
Tuberous sclerosis complex (TSC) is a multisystem genetic disorder characterised by widespread hamartomas in organs such as the skin, brain, heart, lung, liver and kidney. Although associations of TSC with hamartomas, angiomyolipomas and fibromas have been reported, there has been no report of its association with malignant melanoma. Herein, we describe a 31-year-old man with malignant melanoma associated with TSC. The patient had a history of epilepsia, multiple hypomelanotic macules, periungual fibromas and multiple hepatic lesions. Malignant melanoma was diagnosed by hepatic biopsy. To the best of our knowledge, this is the first report of malignant melanoma coexisting with TSC in the literature. We also present and discuss the imaging findings, prognosis, underlying mechanisms and practical approaches in relation to the disease.
Adult
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Biopsy, Needle
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Follow-Up Studies
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Humans
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Immunohistochemistry
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Magnetic Resonance Imaging
;
methods
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Male
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Melanoma
;
complications
;
diagnosis
;
therapy
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Multimodal Imaging
;
methods
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Positron-Emission Tomography
;
methods
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Rare Diseases
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Risk Assessment
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Skin Neoplasms
;
complications
;
diagnosis
;
therapy
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Tomography, X-Ray Computed
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methods
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Tuberous Sclerosis
;
complications
;
diagnosis