Objective To study the multi-slice computed tomography (MSCT) features of pancreatic neuroendocrine tumors (PNET).Methods In the retrospective study,30 histologically verified pancreatic neuroendocrine tumors were incidentally detected with contrast enhanced MSCT.Various CT findings such as location,size,pattern,enhancement were analyzed.All tumors were graded as G1 to G3 according to WHO classification in 2010.Results There were 30 lesions in 30 patients with histologically confirmed PNET,including 16 lesions in G1,6 lesions in G2,and 8 lesions in G3.16 lesions were located in head of pancreas,8 lesions located in pancreatic body,and 6 lesions located in tail of pancreas.16 tumors were solid,3 tumors predominantly cystic,and 11 lesions solid and cystic.Calcification was observed in 6 cases.There was no significant difference in tumor location,size,solid or cystic,calcification among the different pathological grades of the tumor.CT values in patients with G1 PNETs in arterial,portal and delay phase were higher than those in patients with G3 PNETs (P＜0.05).Conclusion Dynamic enhancement CT may provide useful information to preoperative grading of PNET and tumors in a higher grade may show poorer enhancement.

Objective To study the diagnostic value of MSCT in cystic lung cancer with ground glass opacity(GGO),and improve understanding of the disease as well as diagnostic accuracy.Methods 2 1 cases of pathologically confirmed cystic lung cancer with GGO were analyzed retrospectively,all patients were examined by MSCT.CT features of the GGO and the cysts,including bronchovascular convergence sign,speculation sign,pleural indentation sign,lobulation,thickness and uniformity of the cyst wall,septa and the location of the lesion were analyzed.Results The image findings of the 21 cases of the cystic lung cancer with GGO included:bronchovasular convergence sign in 6 cases(28.6%),speculation sign in 10 cases(47.7%),pleural indentation sign in 12 cases(57.1%),lobulation in 8 cases(38.1%),10 cases(47.7%)showed pure GGO.The cyst wall was(1.7±0.9)mm in thickness and the cyst was (13.2±7.0)mm in diameter.Cyst wall was uniform in 9 cases(42.9%),septa was seen in 14 cases(66.7%),cysts of 16 cases(76.1%)were located in the upper lobes of the lung,1 case(4.7%)had distinctly mediastinal lymph node metastasis.Air-fluid lever,mural nodule or intrapulmonary metastasis were not present in any of the cases.Conclusion The majority of the cystic lung cancer with GGO are adenocarcinoma.In addition of the interference of its prominent cystic features on MSCT,the cystic lung cancer have characteristics of lung cancer with GGO.By analyzing its CT features,diagnostic accuracy can be improved before operation.

Tie2 expressing monocytes/macrophages (TEMs) are a subtype of monocytes or macrophages which expressing tyrosine kinase receptor Tie2. They can exist in peripheral blood and tissues of both human and mouse. TEMs can participate in the formation of tumor microenvironment by accelerating tumor angiogenesis, lymphangiogenesis and immunosuppression. At present, TEMs have been found to have potential diagnostic and prognostic guiding significance for a variety of tumors, and they are expected to provide new directions and strategies for tumor therapy. This paper reviews the research progress of TEMs in tumor.