Objective To investigate the clinical characteristics,surgical strategy,pathological features and prognosis of pulmonary pleomorphic carcinoma.Methods The clinicopathological data of 23 patients with pulmonary pleomorphic carcinoma who underwent surgical resection from January 201 0 to March 201 4 in Tongji Hospital were collected.Results There were 1 6 male patients and 7 female pa-tients,with the male /female ratio of 2.3∶1 .The mean age of was 54(35 ~75)years old.A total of 1 7 pa-tients were heavy smokers and the mean smoking index was 688(400 -1 200).The initial main symptoms were cough,blood in phlegm and hemoptysis.It was difficult for fiberoptic bronchoscopy to confirm the di-agnosis.All patients underwent surgical resection,including 22 cases of radical resection and one case of biopsy.Microscopically,neoplastic epithelial cells and pleomorphic components were found in pulmonary pleomorphic carcinoma in 1 9 cases,and pleomorphic components only in the other 4 cases.Positive CK ex-pression in pleomorphic components was observed.The longest survival time was 1 8 months and the pa-tient was still alive.The median survival time was 1 2 months.Conclusion Pulmonary pleomorphic carci-noma usually occurs in middle-aged and elderly male smokers.Immunohistochemistry staining contribute to the diagnosis.The main treatment is surgery and the prognosis is poor.