1.Notch signaling regulates macrophages during inflammation and infection: An update.
Chuxi CHEN ; Qiaoyuan LIU ; Zhijie HUANG ; Yunshan NING ; Yan LI
Chinese Journal of Cellular and Molecular Immunology 2023;39(5):468-473
Macrophage as a crucial component of innate immunity, plays an important role in inflammation and infection immunity. Notch signal pathway is a highly conserved pathway, which regulates cellular fate and participates in numerous pathological processes. At present, a lot of literature has confirmed the role of Notch signaling in regulating the differentiation, activation and metabolism of macrophage during inflammation and infection. This review focuses on how Notch signaling promotes macrophage pro-inflammatory and anti-infective immune function in different inflammatory and infectious diseases. In this regulation, Notch signaling interact with TLR signaling in macrophages or inflammatory-related cytokines including IL-6, IL-12, and TNF-α. Additionally, the potential application and challenges of Notch signaling as a therapeutic target against inflammation and infectious diseases are also discussed.
Humans
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Signal Transduction
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Macrophages
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Cytokines/metabolism*
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Inflammation/metabolism*
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Communicable Diseases
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Receptors, Notch/metabolism*
2. Predicting the malignancy of pulmonary nodules using baseline chest CT: an application study of deep learning model
Wenhui LYU ; Changsheng ZHOU ; Xinyu LI ; Chuxi HUANG ; Qirui ZHANG ; Li MAO ; Longjiang ZHANG ; Guangming LU
Chinese Journal of Radiology 2019;53(11):957-962
Objective:
To investigate whether a deep learning-based model using unenhanced computed tomography (CT) at baseline could predict the malignancy of pulmonary nodules.
Methods:
A deep learning model was trained and applied for the discrimination of pulmonary nodule in Dr. Wise Lung Analyzer. This study retrospectively recruited 130 consecutive participants with pulmonary nodules detected on CT who undergoing biopsy or surgery from May 2009 to June 2017 in Jinling hospital. A total of 136 pulmonary nodules were included in this study, including 86 malignant nodules and 50 benign ones. All patients underwent CT scans 2 times at least, the first scan was defined as baseline and the last scan before the pathological results was defined as final scan. The ROC curve of deep learning model was plotted and the AUCs were calculated. Delong test was used to examine the difference of AUCs baseline and final scan. The nodules were further divided into subsolid nodule group (pure ground-glass nodule and part solid nodule) (