ObjectiveTo investigate the diagnosis and treatment of Crohn disease in neonates.Methods The clinical data of one case of neonatal onset Crohn disease were retrospectively analyzed.Results Male infant had intermittent fever, recurrent oral ulcers, skin impetigo and intermittent diarrhea with increased WBC counts from ifve days after birth. He had been diagnosed as sepsis, bacterial enteritis, Behcet's disease, immunodeifciency disease, nutritional anemia, milk intolerance, and inlfammatory bowel disease. Finally he was diagnosed as Crohn disease by rectal mucosa pathology and postoperative bowel pa-thology. He died of intestinal perforation on 8 months.ConclusionsThe infants who have recurrent oral ulcers, skin impetigo, perianal ulcers and fever from neonatal should undergo colonoscopy for the diagnosis.

1363 cases of wounds and burn wounds wastreate withtopical application of bee honey with an average thera-peutic course of 14.5 days.the total effective rate be-ing 97.5%.When comparison made with 635 casestreated by antibiotics,the results were significantlydifferent.Observations revealed that bee honey pos-sesses the actions of nourishing the wounds,antiin-flammation,antimicrobe,absorption and decrease ofexudation,improvement of healing.

Results: All 29 patients (33 feet) were followed up 12-22 months with an average of 18 months. All patients restored line plantar foot without needle infection and nerve or vessel injury. One foot had a mild relapse of deformity at 6 months after removal of external fixator, and the gait restored to normal after symptomatic treatment. The rest of 32 feet had no deformity recurrence during the follow-up. At last follow-up, International Club Foot Study Group (ICFSG) score (5.21±3.91) was significantly lower than the preoperative score (36.73±4.80), and the difference was significant ( t=47.227, P=0.000). The results were excellent in 27 feet, good in 3 feet, and fair in 3 feet, and the excellent and good rate was 90.91%. The patients were very satisfied in 27 feet and satisfied in 6 feet by self-evaluation of effectiveness.

Objective? To explore application effect of personalized nursing in heparin catheter-locking anticoagulant therapy of patients with fractures. Methods? Based on the convenience random number table method, a total of 90 fracture patients in Tangshan Gongren Hospital receiving heparin catheter-locking anticoagulant therapy from June of 2016 to October of 2018 were selected and divided into the observation group and control group with 45 cases in each group. The observation group was given routine nursing during the period of heparin catheter-locking anticoagulant therapy, on the basis of that, the observation group received personalized nursing intervention. The two groups were compared in the disappearance time of symptoms, blood loss after operation, coagulation function [platelet count (PLT), fibrinogen (FIB), D-dimer (D-D)]and complications before and after intervention. Results? The disappearance time of pain, swelling and ecchymosis in the observation group was shorter than that in the control group, but the blood loss was less than that in the control group (P＜ 0.05); the levels of PLT, FIB and D-D in the observation group were lower than those in the control group (P＜0.05); the incidence of complications in the observation group was 8.88%, lower than 26.66% in the control group one month after the intervention (P＜0.05). Conclusions? Personalized nursing intervention can improve the nursing quality for fracture patients under heparin catheter-locking anticoagulant therapy and improve their coagulation function and reduce the complications after catheterization.