1.Effect of sand therapy on femur mechanical properties of arthritis in rabbits and finite element analysis.
Chunyuan KONG ; Dilinaer MAHEMUTI ; Rong WEI
Journal of Central South University(Medical Sciences) 2009;34(1):8-12
OBJECTIVE:
To determine the effect of sand therapy on the changes the femur mechanical properties of arthritis in rabbits in treatment.
METHODS:
Right knees of New Zealand rabbits were fixed for 6 weeks by plaster, and taken off after 6 weeks. The rabbits were divided into a sand therapy group and a control group. The sand therapy group was treated for 20 d, the control group did not receive any treatment. After 20 days, 7 workpieces were taken from the sand therapy group, and 5 from the control group. After compression experiment, sigma-epsilon curves were obtained.Finite element method was used to analyze the stress cloud and the deformation cloud.
RESULTS:
The sand therapy group showed high compressive strength. The stress of the control group was lower than that of the sand therapy group (P<0.05). When the surface materials were destroyed, the workpieces from the sand therapy group still bore large load, which matched the property that bone material was a typical multi-storey composite material. The stress cloud also found that the long axle suffered larger stress than the short axle, and the workpieces were more likely destroyed from the long axle.
CONCLUSION
Sand therapy can improve the mechanical properties of the bone.
Animals
;
Femur
;
physiopathology
;
Finite Element Analysis
;
Hot Temperature
;
therapeutic use
;
Knee Joint
;
Male
;
Medicine, Chinese Traditional
;
methods
;
Osteoarthritis
;
metabolism
;
therapy
;
Rabbits
;
Random Allocation
;
Silicon Dioxide
;
Stress, Mechanical
;
Tensile Strength
2.Polyoxypregnanes as safe, potent, and specific ABCB1-inhibitory pro-drugs to overcome multidrug resistance in cancer chemotherapy
Xu WU ; Chun YIN ; Jiang MA ; Stella CHAI ; Chunyuan ZHANG ; Sheng YAO ; Onat KADIOGLU ; Thomas EFFERTH ; Yang YE ; Kenneth Kin-Wah TO ; Ge LIN
Acta Pharmaceutica Sinica B 2021;11(7):1885-1902
Multidrug resistance (MDR) mediated by ATP binding cassette subfamily B member 1 (ABCB1) is significantly hindering effective cancer chemotherapy. However, currently, no ABCB1-inhibitory drugs have been approved to treat MDR cancer clinically, mainly due to the inhibitor specificity, toxicity, and drug interactions. Here, we reported that three polyoxypregnanes (POPs) as the most abundant constituents of