Objective To investigate the effects of hyperbaric oxygen combined with intravenous thrombolysis in the treatment of large atherosclerotic stroke(LAA)and non-LAA and the related factors affecting its short-term outcome.Methods One hundred and four patients with acute ischemic stroke of anterior circulation who received hyperbaric oxygen combined with intravenous thrombolysis in our hospital from October 2020 to October 2022 were retrospectively selected.According to TOAST classification,they were divided into LAA group and non-LAA group.The clinical outcome and NIHSS score were compared between the two groups,and the safety of treatment was evaluated.Logistic regression was used to analyze the related factors of short-term outcomes in patients with different etiological types after treatment.Results There were 62 patients in LAA group and 42 patients in non-LAA group.There was no significant difference between the two groups in the baseline data,clinical outcomes,NIHSS scores and safety outcomes(all P＞0.05).Logistic analysis showed that the short-term outcome of patients treated with hyperbaric oxygen combined with intravenous thrombolysis was not related to TOAST classification(P＞0.05),but was related to hypertension,hyperlipidemia,baseline NIHSS score,white blood cell count/mean platelet volume(WMR)and red blood cell distribution width(RDW)(all P＜0.05).Conclusion The efficacy and safety of hyperbaric oxygen combined with intravenous thrombolysis in LAA and non-LAA are comparable,and the short-term outcome after treatment is related to hypertension,hyperlipidemia,baseline NIHSS score,WMR and RDW levels.

It was generally believed that muscular atrophy of paralyzed limbs after stroke was due to disuse. However, recent studies have found that secondary lesions of motor neurons in the contralateral anterior horn of the spinal cord and the decrease of motor units lead to denervation, which plays an essential role in muscular atrophy and muscle fiber type transition. This article reviews the phenomenon and mechanism of muscular atrophy and denervation of paralyzed limbs after stroke, to provide a reference for clinical evaluation and experimental research.

[Objective] To summarize the clinical manifestations, pathological characteristics, treatment options and prognosis of the world's first case of prostate ductal adenocarcinoma (PDA) complicated with prostate mucinous adenocarcinoma (PMA). [Methods] The clinical and follow-up data of a patient with PDA and PMA treated in Zhongnan Hospital of Wuhan University were retrospectively analyzed, and relevant literature in PubMed and CNKI databases was retrieved. [Results] The patient sought medical attention due to dysuria, frequent urination, urinary urgency and urinary pain for more than half a year, and was admitted to hospital 3 times in total.The initial diagnosis upon the first admission was benign prostatic hyperplasia complicated with prostatic abscess.After 2 months, the patient was readmitted due to worsening symptoms, received transurethral bladder neck incision+ cystoscopy+ transurethral plasma resection of the prostate, and postoperative diagnosis confirmed PDA with local PMA.Three months after surgery, the patient had bleeding.After auxiliary examinations revealed extensive metastasis, he received hormonal therapy.After 9 months, the patient died due to multiple lung metastases. [Conclusion] Early diagnosis has a significant impact on the treatment and prognosis, but there have been no previous reports of PDA combined with PMA, so the lack of specific biomarkers in the early stage has led to missed diagnosis or misdiagnoses.There is no specific treatment for PDA with PMA. Radical prostatectomy was not satisfactory in the treatment of this case.