The Traditional Chinese Medical Pulse Instrument uses the HKG-07B infrared pulse sensor to get pulse signal from the body. It makes full use of the TMS320VC5402 chip to realize time-frequency domain parameters extracting, classification and identification of the pulse signal. The system can store a plenty of pulse signal and realize data communication with the PC via the USB interface. According to acquisition and classification of pulse signal experiments of 200 subjects, the results show that the recognition rate of pulse signal can reach to 87.4%. It is applicable to the clinical diagnosis and detection of the pulse signal and home healthcare.
Equipment Design ; Humans ; Medicine, Chinese Traditional ; methods ; Signal Processing, Computer-Assisted ; Software Design

Anti-virulence strategy has been considered as one of the most promising approaches to combat drug-resistant bacterial infections. Pore-forming toxins (PFTs) are the largest class of bacterial toxins, inflicting their virulence effect through creating pores on the cell membrane. However, current solutions for eliminating PFTs are mostly designed based on their molecular structure, requiring customized design for different interactions. In the present study, we employed erythroliposome (denoted as RM-PL), a biomimetic platform constructed by artificial lipid membranes and natural erythrocyte membranes, to neutralize different hemolytic PFTs regardless of their molecular structure. When tested with model PFTs, including α-hemolysin, listeriolysin O, and streptolysin O, RM-PL could completely inhibit toxin-induced hemolysis in a concentration-dependent manner. In vivo studies further confirmed that RM-PL could efficiently neutralize various toxins and save animals' lives without causing damage to organs or tissues. In addition, we explored the underlying mechanisms of this efficient detoxification ability and found that it was mainly macrophages in the spleen and the liver that took up RM-PL-absorbed toxins through a variety of endocytosis pathways and digested them in lysosomes. In summary, the biomimetic RM-PL presented a promising system for broad-spectrum and powerful toxin neutralization with a mechanism of lysosome-mediated toxin degradation.